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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Social Responsibility

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Disease relevance of Social Responsibility


High impact information on Social Responsibility

  • Expression in meiotic prophase precedes the strand breakage that occurs during chromosomal recombination; this offers an avenue for L1 insertion into new locations in chromosomal DNA in a cell type that ensures L1 propagation in future generations [4].
  • With the rapidly changing materials needs of modern microelectronics, germanium provides an opportunity for future-generation devices [5].
  • A highly potent COX-2 inhibitor of the 3(2H)furanone scaffold could be considered suitable for a future generation COX-2 selective arthritis medication with improved safety profiles [6].
  • Useful structure-activity relationships were established which provide important guidelines for the design of future generations of bisubstrate inhibitors of COMT [7].
  • These cases illustrate the consequences of COL7A1 glycine substitution mutations underlying DEB in terms of the mode of inheritance and the phenotype, with profound implications for genetic counseling of individuals at risk for recurrence of DEB in subsequent offspring or future generations [8].

Anatomical context of Social Responsibility

  • Investigators and clinicians of today must recognise that, like their predecessors with an interest in flexor tendon surgery, they will contribute to the understanding of this very important structure, but they also will leave unanswered questions for future generations [9].

Associations of Social Responsibility with chemical compounds


Gene context of Social Responsibility


  1. Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease. Dauber, D.S., Ziermann, R., Parkin, N., Maly, D.J., Mahrus, S., Harris, J.L., Ellman, J.A., Petropoulos, C., Craik, C.S. J. Virol. (2002) [Pubmed]
  2. Transmission of male infertility to future generations: lessons from the Y chromosome. Silber, S.J., Repping, S. Hum. Reprod. Update (2002) [Pubmed]
  3. Respiratory muscles as a target for adenovirus-mediated gene therapy. Petrof, B.J. Eur. Respir. J. (1998) [Pubmed]
  4. Developmental and cell type specificity of LINE-1 expression in mouse testis: implications for transposition. Branciforte, D., Martin, S.L. Mol. Cell. Biol. (1994) [Pubmed]
  5. REACTIVITY OF THE GERMANIUM SURFACE: Chemical Passivation and Functionalization. Loscutoff, P.W., Bent, S.F. Annual review of physical chemistry. (2006) [Pubmed]
  6. In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. Shin, S.S., Byun, Y., Lim, K.M., Choi, J.K., Lee, K.W., Moh, J.H., Kim, J.K., Jeong, Y.S., Kim, J.Y., Choi, Y.H., Koh, H.J., Park, Y.H., Oh, Y.I., Noh, M.S., Chung, S. J. Med. Chem. (2004) [Pubmed]
  7. Structure-based design, synthesis, and in vitro evaluation of bisubstrate inhibitors for catechol O-methyltransferase (COMT). Masjost, B., Ballmer, P., Borroni, E., Zürcher, G., Winkler, F.K., Jakob-Roetne, R., Diederich, F. Chemistry (Weinheim an der Bergstrasse, Germany) (2000) [Pubmed]
  8. Glycine substitution mutations in the type VII collagen gene (COL7A1) in dystrophic epidermolysis bullosa: implications for genetic counseling. Kon, A., McGrath, J.A., Pulkkinen, L., Nomura, K., Nakamura, T., Maekawa, Y., Christiano, A.M., Hashimoto, I., Uitto, J. J. Invest. Dermatol. (1997) [Pubmed]
  9. Flexor tendon healing. Manske, P.R. Journal of hand surgery (Edinburgh, Lothian) (1988) [Pubmed]
  10. Structural constraints in the design of silver sulfonate coordination networks: three new polysulfonate open frameworks. Hoffart, D.J., Dalrymple, S.A., Shimizu, G.K. Inorganic chemistry. (2005) [Pubmed]
  11. Induction of mosaic sex-linked recessive lethals in the different germ cell stages of Drosophila melanogaster by bleomycin. Sadiq, M.F., Khabour, O.F. Mutat. Res. (1998) [Pubmed]
  12. 2,4-D induced clastogenicity and elevated rates of sister chromatid exchanges in cultured human lymphocytes. Korte, C., Jalal, S.M. J. Hered. (1982) [Pubmed]
  13. From what should we protect future generations: germ-line therapy or genetic screening? Mallia, P., ten Have, H. Medicine, health care, and philosophy. (2003) [Pubmed]
  14. The use of the MMPI special scales in the assessment of delinquent personality. Weaver, G.M., Wootton, R.R. Adolescence. (1992) [Pubmed]
  15. Cyclooxygenase-1 and -2 isoenzymes. Hla, T., Bishop-Bailey, D., Liu, C.H., Schaefers, H.J., Trifan, O.C. Int. J. Biochem. Cell Biol. (1999) [Pubmed]
  16. Thrombolytic agents--an overview. Gulba, D.C., Bode, C., Runge, M.S., Huber, K. Ann. Hematol. (1996) [Pubmed]
  17. Somatostatin analogues and multiple receptors: possible physiological roles. Coy, D.H., Rossowski, W.J. Ciba Found. Symp. (1995) [Pubmed]
  18. Two future generations of blood substitutes based on polyhemoglobin-SOD-catalase and nanoencapsulation. Chang, T.M., D'Agnillo, F., Yu, W.P., Razack, S. Adv. Drug Deliv. Rev. (2000) [Pubmed]
  19. Does intracytoplasmic sperm injection lead to a rise in the frequency of microdeletions in the AZFc region of the Y chromosome in future generations? Kremer, J.A., Tuerlings, J.H., Borm, G., Hoefsloot, L.H., Meuleman, E.J., Braat, D.D., Brunner, H.G., Merkus, H.M. Hum. Reprod. (1998) [Pubmed]
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