Disease relevance of Social Responsibility

• Understanding the altered substrate specificity of drug-resistant HIV PR should be valuable in the design of future generations of protease inhibitors as well as in elucidating the molecular basis of regulation of proteolysis in HIV [1].
• Transmission of male infertility to future generations: lessons from the Y chromosome [2].
• These results have important implications for the design of future generation vectors and the potential need for immunosuppressive therapy after recombinant adenovirus vector mediated dystrophin gene transfer to Duchenne muscular dystrophy patients [3].

High impact information on Social Responsibility

• Expression in meiotic prophase precedes the strand breakage that occurs during chromosomal recombination; this offers an avenue for L1 insertion into new locations in chromosomal DNA in a cell type that ensures L1 propagation in future generations [4].
• With the rapidly changing materials needs of modern microelectronics, germanium provides an opportunity for future-generation devices [5].
• A highly potent COX-2 inhibitor of the 3(2H)furanone scaffold could be considered suitable for a future generation COX-2 selective arthritis medication with improved safety profiles [6].
• Useful structure-activity relationships were established which provide important guidelines for the design of future generations of bisubstrate inhibitors of COMT [7].
• These cases illustrate the consequences of COL7A1 glycine substitution mutations underlying DEB in terms of the mode of inheritance and the phenotype, with profound implications for genetic counseling of individuals at risk for recurrence of DEB in subsequent offspring or future generations [8].

Anatomical context of Social Responsibility

• Investigators and clinicians of today must recognise that, like their predecessors with an interest in flexor tendon surgery, they will contribute to the understanding of this very important structure, but they also will leave unanswered questions for future generations [9].

Associations of Social Responsibility with chemical compounds

• Three new silver sulfonate metal-organic frameworks are presented along with a design strategy for future generations [10].
• The significant production of mosaic progeny in the F4 generation of the treated males showed that the mosaic F1 females produced by bleomycin were able to produce further mosaic progeny and suggested that bleomycin-induced instabilities can be transmitted as such for many future generations [11].
• Potential for genetic damage in future generations from such widely used hormonic herbicide as 2,4-D (2,4-dichlorophenoxyacetic acid) is of serious concern [12].
• The concept of 'Guardian for Future Generations' is tackled and its main criticisms discussed [13].
• Scales that best discriminated between high and low levels of recidivism and property offenses were Pd (Psychopathic Deviance), Ma1 (Amorality), Pd2 (Authority Problems), Re (Social Responsibility), and MAC (MacAndrew Alcoholism) [14].

Gene context of Social Responsibility

• Inhibition of the COX isoenzyme activity and/or expression may be the basis of future generation of anti-inflammatory and anti-neoplastic drugs [15].
• This review summarizes the current knowledge on the biochemical and pharmacological properties of the first, second and future generation of plasminogen activators [16].
• It is anticipated that these and future generations of analogues will have distinct therapeutic advantages over somatostatin itself and presently available cyclic octapeptides [17].
• Two future generations of blood substitutes based on polyhemoglobin-SOD-catalase and nanoencapsulation [18].
• Does intracytoplasmic sperm injection lead to a rise in the frequency of microdeletions in the AZFc region of the Y chromosome in future generations [19]?

References