The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Guardian     [cyano-(3- phenoxyphenyl)methyl] 2-[4...

Synonyms: Cythrin, Aastar, CyBolt, FLUCYTHRINATE, Fluorocythrin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Fluorocythrin

  • Long-term multicenter experience with a second-generation implantable pacemaker-defibrillator in patients with malignant ventricular tachyarrhythmias. The Guardian Multicenter Investigators Group [1].
  • The Pmax of 'Guardian' was depressed by at least 23% by heat stress at each stage; this inhibition was least at ear emergence and greatest at anthesis, the latter being associated with reduced sink size as a result of lowered seed set [2].
  • The purposes of this study were to demonstrate the accuracy and effectiveness of the Guardian Continuous Monitoring System (Medtronic MiniMed, Northridge, California) and to demonstrate that the application of real-time alarms to continuous monitoring alerts users to hypo and hyperglycemia and reduces excursions in people with diabetes [3].
  • CONCLUSIONS: Guardian RT real-time subcutaneous blood glucose measurement is safe and potentially useful for continuous glucose monitoring in critically ill children [4].
  • In addition to historical background, the devices discussed here include (in alphabetical order) the Amplatzer Septal Occluder, the Atrial Septal Defect Occlusion System, the Buttoned Device, the Guardian Angel (Angel Wings), the Helex Septal Occluder, the StarFlex (Cardioseal, Clamshell), and transcatheter patch closure of atrial septal defects [5].

High impact information on Fluorocythrin

  • p53, the most commonly mutated gene in human tumors, is believed to play a crucial role in the prevention of cancer by protecting cells from mutation, a theory commonly known as the "Guardian of the Genome" hypothesis [6].
  • Male Sprague-Dawley rats dosed with N-nitrosodiethylamine (NDEA) 24 h after two-thirds partial hepatectomy were treated with the pyrethroid insecticides fenvalerate, flucythrinate or cypermethrin in the diet for 20 weeks [7].
  • The sleep surfaces studied included: firm mattress covered by a sheet, Bumpa Bed, Breathe Easy, Kid Safe/Baby Air, Halo Sleep System, and Sleep Guardian [8].
  • The four genotypes were grafted onto "Guardian" peach rootstock and half of the plants were assigned to a drought treatment in which irrigation was limited to 25-50% of the evapotranspiration (ET) rate measured in the remaining well-watered plants, which were irrigated to runoff daily [9].
  • Forty-three consecutive patients with the Guardian ATP 4210 ICD, which uses an X out of Y sensed interval counting algorithm for tachycardia detection, confirmation, and classification were studied [10].

Biological context of Fluorocythrin

  • Conclusion: These limited data suggest that nocturnal LOH occurs commonly following vigorous exercise and that a Guardian RT is a useful and important diagnostic tool [11].
  • Blood pressure and hemodynamic readings were obtained with the Dynapulse 500 Guardian device (Pulsemetric Inc., San Diego, California, USA), which measures systemic hemodynamics on the basis of oscillometric waveforms obtained through a cuff placed over the brachial artery [12].

Anatomical context of Fluorocythrin

  • Glucose measurements differ between blood samples taken from the finger and interstitial fluid, especially when levels are changing rapidly; however, these results demonstrate that the Guardian is reasonably accurate while performing continuous glucose monitoring [3].
  • Vg titer in the hemolymph of unfed mated females was the same level on day 5 and about three times higher on day 10 after treatment with CyM, Fev, and Flu, as that of engorged adult females [13].

Associations of Fluorocythrin with other chemical compounds

  • Various combinations of fenvalerate-, flucythrinate- and DDT-exposure gave results in accordance with an additive response [14].

Gene context of Fluorocythrin

  • ICD models used in group I were: Ventritex Cadence (16), Telectronics Guardian 4211 (2), Medtronic PCD (7); in group II they were: Ventritex Cadence (15), Guardian 4211 (2), and CPI 1600 (1) [15].
  • The Nolan Poolift (Guardian Products, Arleta, Calif.) is a water-powered pool lift, which automatically rotates as it descends [16].
  • In my role as court-appointed Guardian ad Litem (GAL-court investigator), it appears to me that Mr. Finelli is being treated against his stated goals and values [17].

Analytical, diagnostic and therapeutic context of Fluorocythrin


  1. Long-term multicenter experience with a second-generation implantable pacemaker-defibrillator in patients with malignant ventricular tachyarrhythmias. The Guardian Multicenter Investigators Group. Saksena, S., Poczobutt-Johanos, M., Castle, L.W., Fogoros, R.N., Alpert, B.L., Kron, J., Pacifico, A., Griffin, J., Ruskin, J.N., Kehoe, R.F. J. Am. Coll. Cardiol. (1992) [Pubmed]
  2. Isolation and analysis of thermotolerant mutants of wheat. Mullarkey, M., Jones, P. J. Exp. Bot. (2000) [Pubmed]
  3. Alarms based on real-time sensor glucose values alert patients to hypo- and hyperglycemia: the guardian continuous monitoring system. Bode, B., Gross, K., Rikalo, N., Schwartz, S., Wahl, T., Page, C., Gross, T., Mastrototaro, J. Diabetes Technol. Ther. (2004) [Pubmed]
  4. Real-time continuous glucose monitoring in pediatric patients during and after cardiac surgery. Piper, H.G., Alexander, J.L., Shukla, A., Pigula, F., Costello, J.M., Laussen, P.C., Jaksic, T., Agus, M.S. Pediatrics (2006) [Pubmed]
  5. Percutaneous catheter closure of secundum atrial septal defects: a review. Ebeid, M.R. The Journal of invasive cardiology. (2002) [Pubmed]
  6. Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells. Bielas, J.H., Heddle, J.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Enhancement of altered hepatic foci in rat liver and inhibition of intercellular communication in vitro by the pyrethroid insecticides fenvalerate, flucythrinate and cypermethrin. Hemming, H., Flodström, S., Wärngård, L. Carcinogenesis (1993) [Pubmed]
  8. Potential to prevent carbon dioxide rebreathing of commercial products marketed to reduce sudden infant death syndrome risk. Carolan, P.L., Wheeler, W.B., Ross, J.D., Kemp, R.J. Pediatrics (2000) [Pubmed]
  9. Responses of Prunus ferganensis, Prunus persica and two interspecific hybrids to moderate drought stress. Rieger, M., Lo Bianco, R., Okie, W.R. Tree Physiol. (2003) [Pubmed]
  10. Limitations of tachycardia confirmation and rate classification algorithms in a third-generation implantable cardioverter defibrillator. Stambler, B.S., Wood, M.A., Ellenbogen, K.A. Pacing and clinical electrophysiology : PACE. (1996) [Pubmed]
  11. Efficacy of continuous real-time blood glucose monitoring during and after prolonged high-intensity cycling exercise: spinning with a continuous glucose monitoring system. Iscoe, K.E., Campbell, J.E., Jamnik, V., Perkins, B.A., Riddell, M.C. Diabetes Technol. Ther. (2006) [Pubmed]
  12. Reliability of a noninvasive device to measure systemic hemodynamics in hemodialysis patients. Motiwala, S., Brewster, U.C., Perazella, M.A., Peixoto, A.J. Blood pressure monitoring. (2006) [Pubmed]
  13. Stimulation of vitellogenesis by pyrethroids in mated and virgin female adults, male adults, and fourth instar females of Ornithodoros moubata (Acari: Argasidae). Taylor, D., Chinzei, Y., Ito, K., Higuchi, N., Ando, K. J. Med. Entomol. (1991) [Pubmed]
  14. Effects of tetradecanoyl phorbol acetate, pyrethroids and DDT in the V79. Wärngård, L., Flodström, S. Cell Biol. Toxicol. (1989) [Pubmed]
  15. Cost and length of hospital stay: comparisons between nonthoracotomy and epicardial techniques in patients receiving implantable cardioverter defibrillators. Luceri, R.M., Zilo, P., Habal, S.M., David, I.B. Pacing and clinical electrophysiology : PACE. (1995) [Pubmed]
  16. Aquatic access for the disabled. Walk, E.E., Himel, H.N., Batra, E.K., Baruch, L., O'Connor, M.B., Tanner, A.E., Edlich, R.F. The Journal of burn care & rehabilitation. (1992) [Pubmed]
  17. Do those who cannot speak really have a voice? Dew, B. Law, medicine & health care : a publication of the American Society of Law & Medicine. (1992) [Pubmed]
  18. Lessons learned from data logging in a multicenter clinical trial using a late-generation implantable cardioverter-defibrillator. The Guardian ATP 4210 Multicenter Investigators Group. Wood, M.A., Stambler, B.S., Damiano, R.J., Greenway, P., Ellenbogen, K.A. J. Am. Coll. Cardiol. (1994) [Pubmed]
  19. Thin-layer chromatography of flucythrinate residues. Singh, P.P., Chawla, R.P. J. Chromatogr. (1988) [Pubmed]
  20. Evaluation of a medical diagnosis system using simulator test scenarios. Larsson, J.E., Hayes-Roth, B., Gaba, D.M., Smith, B.E. Artificial intelligence in medicine. (1997) [Pubmed]
  21. A monoclonal antibody-based ELISA for the analysis of the insecticide flucythrinate in environmental and crop samples. Nakata, M., Fukushima, A., Ohkawa, H. Pest Manag. Sci. (2001) [Pubmed]
WikiGenes - Universities