Disease relevance of Rectal Prolapse

• Plasminogen (Plg) deficiency in mice results in high mortality, wasting, spontaneous gastrointestinal ulceration, rectal prolapse, and severe thrombosis [1].
• The adult had a single bladder, a bifid scrotum, a low abdominal wall hernia, separation of the symphysis pubis, bilateral inguinal hernias, rectal prolapse, bilateral vesicoureteral reflux and bilateral staghorn calculi [2].
• Older children with CF may present with bowel obstruction due to distal intestinal obstruction syndrome or colonic stricture, and tenacious intestinal residue may serve as a lead point for intussusception or cause recurrent rectal prolapse [3].
• The correction of dystocia, periparturient vaginal, uterine and rectal prolapses is greatly facilitated after epidural injection of lignocaine, or a combination of xylazine and lignocaine administered by a veterinary surgeon [4].
• Rectal examination on these 82 patients showed that 10(3.7% of 272) had haemorrhoids, 2(0.7% ) had rectal prolapse, 0.7% had peri-anal warts; 15(5.5% ) anal tags, 10(3.7% ) chronic anal fissure, 2 (0.7% ) perianal fistulae [5].

High impact information on Rectal Prolapse

• Additional phenotypic abnormalities such as dystrophic calcifications and rectal prolapse were also observed in the uPA-deficient population [6].
• Histological features in the first (presence of intramucosal elastin) and clinical features in the second (rectal prolapse) support the above hypothesis [7].
• Prospective randomized trial of Ivalon sponge versus sutured rectopexy for full-thickness rectal prolapse [8].
• Between 1977 and 1987, 53 patients underwent polyvinyl alcohol sponge rectopexy for complete rectal prolapse [9].
• External pelvic rectal suspension (the Express procedure) for full-thickness rectal prolapse: evolution of a new technique [10].

Chemical compound and disease context of Rectal Prolapse

• The long-term outcome of Ivalon sponge rectopexy for rectal prolapse in a group of young patients was reviewed [11].
• Sucrose as an aid to manual reduction of incarcerated rectal prolapse [12].
• The injection of 5% phenol in oil into the rectal submucosa cured persistent rectal prolapse in 91 of 100 young children [13].
• A prospective, randomized study comparing abdominal rectopexy and sigmoid resection (Group I; n = 15) with polyglycolic acid mesh rectopexy without sigmoidectomy (Group II; n = 15) for complete rectal prolapse was carried out [14].
• BACKGROUND AND AIMS: Optimal treatment for rectal prolapse is controversial [15].

Anatomical context of Rectal Prolapse

• Previous unsuccessful treatment for rectal prolapse included a Thiersch wire or a Silastic perianal sling in 19, electrical therapy in 12, rectopexy with polyvinyl alcohol sponge (Ivalon) in 5 and pelvic floor repair in 2 [16].

Gene context of Rectal Prolapse

• It was therefore surprising that mice deficient for IL-4 in addition to IL-10 showed intestinal pathology very rarely, whereas IL-10 KO mice developed rectal prolapse in most cases [17].
• We describe a case very rare in the West African sub-region, Familial Polyposis Coli, presenting with rectal prolapse [18].

References