Disease relevance of Lymphoma, Large-Cell, Ki-1

• Ki-1 (CD30) positive anaplastic large cell lymphoma (ALCL) is an uncommon, high-grade non-Hodgkin's lymphoma with distinct morphologic and immunohistochemical features [1].
• CD30, which is positive for anaplastic large cell lymphoma (Ki-1 lymphoma), was not expressed [2].
• BACKGROUND: Large cell anaplastic Ki-1 lymphoma is a cytologically undifferentiated malignant lymphoma that needs to be distinguished from a variety of other neoplasms using immunohistochemistry [3].
• These findings were compatible with Ki-1 lymphoma, suggesting that this may be a case of CD30/Ki-1 lymphoma preceded by Hodgkin's disease and that a certain proportion of Ki-1 lymphomas and Hodgkin's disease may share the same cellular origin [4].
• Primary CD30/Ki-1 positive anaplastic large cell lymphoma of the central nervous system occurring in a patient with a seventeen-year history of essential thrombocythemia [5].

High impact information on Lymphoma, Large-Cell, Ki-1

• We have molecularly cloned a cDNA encoding a protein uniquely expressed and hyperphosphorylated at tyrosine residues in a Ki-1 lymphoma cell that contained chromosomal translocation t(2;5) [6].
• Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5) [6].
• DNA synthesis by Ki-1 lymphoma cells was increased 138-fold by anti-TGF beta 1 antibody and 262-fold by anti-Hodgkin's TGF beta [7].
• Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3 [8].
• Molecular variant of the NPM-ALK rearrangement of Ki-1 lymphoma involving a cryptic ALK splice site [9].

Chemical compound and disease context of Lymphoma, Large-Cell, Ki-1

• METHODS: We reviewed our 20-year experience with the use of methotrexate in 45 patients with relatively severe LyP, Ki-1+ lymphoma, and interface presentations [10].
• A 35-year-old man with refractory cutaneous Ki-1 lymphoma was salvaged successfully with oral 13-cis-retinoic acid (1 mg/kg/day) [11].
• Stage IV CD30+ anaplastic large cell lymphoma: response to acitretin and interferon-alpha [12].

Biological context of Lymphoma, Large-Cell, Ki-1

• The addition of picogram quantities of exogenous TGF-beta to cell cultures of indolent Ki-1 lymphoma (Mac-1) suppresses IL-2-dependent mitosis; however, the suppression is less than 45% [13].
• Detection of the NPM-ALK genomic rearrangement of Ki-1 lymphoma and isolation of the involved NPM and ALK introns [14].
• Dual action of CD30 antigen: anti-CD30 antibody induced apoptosis and interleukin-8 secretion in Ki-1 lymphoma cells [15].
• In addition, the existence of a minor aneuploid tumour cell population of high proliferation such as that in Ki-1 lymphomas will not be accurately analysed by FCM but is easily assessed by Ki-67 staining [16].
• The diagnosis of Ki-1 lymphoma was first confirmed by the distinct pleomorphic morphology, expression of Ki-1 (CD30) antigen on neoplastic cells and the specific chromosome translocation, t(2;5)(p23;q35) [17].

Anatomical context of Lymphoma, Large-Cell, Ki-1

• The biopsy from erythematous skin lesion of trunk showed infiltration of medium sized atypical lymphoid cells with relatively plump cytoplasm and immunophenotype of CD30+, CD56+/- and surface CD3-, which lead to the diagnosis of CD30+ anaplastic large cell lymphoma [18].
• Primary CD30/Ki-1 positive anaplastic large cell lymphoma of skeletal muscle with der(17)t(1;17)(q11;p11) [19].

Gene context of Lymphoma, Large-Cell, Ki-1

• A permanent cell line, HSC-M1, was established from a child with advanced CD30 (Ki-1)+ anaplastic large-cell lymphoma (ALCL) [20].
• The large cells of the large-cell anaplastic (Ki-1+) lymphoma expressed the antigens CD30 and CD45 and were negative for CD15 [21].
• Nodular tumors of the skin, identified as highly malignant Ki-1 lymphomas of large anaplastic cells, had intense GH receptor immunoreactivity [22].
• High serum levels of CA125 and interleukin-6 in a patient with Ki-1 lymphoma [23].
• CD56 expression in a case of primary cutaneous CD30+ anaplastic large cell lymphoma [24].

Analytical, diagnostic and therapeutic context of Lymphoma, Large-Cell, Ki-1

• Similar immunophenotyping studies have also shown cases previously diagnosed as MH or THL express lymphoid antigens, and would now be classified as Ki-1 positive anaplastic large cell lymphoma (ALCL) or some other hematopoietic neoplasm [25].

References