Gene Review:
GHR - growth hormone receptor
Homo sapiens
Synonyms:
GH receptor, GHBP, Growth hormone receptor, Somatotropin receptor
Tiulpakov,
Rubtsov,
Dedov,
Peterkova,
Bezlepkina,
Chrousos,
Hochberg,
Leung,
Doyle,
Ballesteros,
Sjogren,
Watts,
Low,
Leong,
Ross,
Ho,
Blum,
Machinis,
Shavrikova,
Keller,
Stobbe,
Pfaeffle,
Amselem,
Colao,
Di Sarno,
Marzullo,
Di Somma,
Cerbone,
Landi,
Faggiano,
Merola,
Lombardi,
Muller,
Van Der Lely,
Takahashi,
Shirono,
Arisaka,
Takahashi,
Yagi,
Koga,
Kaji,
Okimura,
Abe,
Tanaka,
Chihara,
Allan,
Shand,
Beattie,
Flint,
Jorge,
Souza,
Arnhold,
Mendonca,
- Differential expression of surface membrane growth hormone receptor on human peripheral blood lymphocytes detected by dual fluorochrome flow cytometry. Badolato, R., Bond, H.M., Valerio, G., Petrella, A., Morrone, G., Waters, M.J., Venuta, S., Tenore, A. J. Clin. Endocrinol. Metab. (1994)
- Activation of the signal transducers and activators of transcription signaling pathway by growth hormone (GH) in skin fibroblasts from normal and GH binding protein-positive Laron Syndrome children. Freeth, J.S., Silva, C.M., Whatmore, A.J., Clayton, P.E. Endocrinology (1998)
- Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells. Weiss-Messer, E., Merom, O., Adi, A., Karry, R., Bidosee, M., Ber, R., Kaploun, A., Stein, A., Barkey, R.J. Mol. Cell. Endocrinol. (2004)
- Clinical pharmacology of human growth hormone and its secretagogues. Root, A.W., Root, M.J. Curr. Drug Targets Immune Endocr. Metabol. Disord. (2002)
- Effects of food deprivation on expression of growth hormone receptor and proximate composition in liver of black seabream Acanthopagrus schlegeli. Deng, L., Zhang, W.M., Lin, H.R., Cheng, C.H. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2004)
- The Palau Early Psychosis Study: Neurocognitive functioning in high-risk adolescents. Myles-Worsley, M., Ord, L.M., Ngiralmau, H., Weaver, S., Blailes, F., Faraone, S.V. Schizophr. Res. (2007)
- Mechanism of signaling by growth hormone receptor. Argetsinger, L.S., Carter-Su, C. Physiol. Rev. (1996)
- A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone. Dos Santos, C., Essioux, L., Teinturier, C., Tauber, M., Goffin, V., Bougnères, P. Nat. Genet. (2004)
- Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group. Goddard, A.D., Covello, R., Luoh, S.M., Clackson, T., Attie, K.M., Gesundheit, N., Rundle, A.C., Wells, J.A., Carlsson, L.M. N. Engl. J. Med. (1995)
- Growth hormone-receptor gene in Laron dwarfism. Bass, S., Wells, J. N. Engl. J. Med. (1990)
- Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. Leung, K.C., Doyle, N., Ballesteros, M., Sjogren, K., Watts, C.K., Low, T.H., Leong, G.M., Ross, R.J., Ho, K.K. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Growth hormone receptor expression and function in meningiomas: effect of a specific receptor antagonist. Friend, K.E., Radinsky, R., McCutcheon, I.E. J. Neurosurg. (1999)
- Pharmacological therapy for acromegaly: a critical review. Muller, A.F., Van Der Lely, A.J. Drugs (2004)
- The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: supression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration. Jorge, A.A., Souza, S.C., Arnhold, I.J., Mendonca, B.B. Clin. Endocrinol. (Oxf) (2004)
- Regulation of growth hormone receptor gene expression. Schwartzbauer, G., Menon, R.K. Mol. Genet. Metab. (1998)
- Biologically inactive growth hormone caused by an amino acid substitution. Takahashi, Y., Shirono, H., Arisaka, O., Takahashi, K., Yagi, T., Koga, J., Kaji, H., Okimura, Y., Abe, H., Tanaka, T., Chihara, K. J. Clin. Invest. (1997)
- A single arginine residue determines species specificity of the human growth hormone receptor. Souza, S.C., Frick, G.P., Wang, X., Kopchick, J.J., Lobo, R.B., Goodman, H.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Growth hormone receptor ubiquitination, endocytosis, and degradation are independent of signal transduction via Janus kinase 2. Alves dos Santos, C.M., ten Broeke, T., Strous, G.J. J. Biol. Chem. (2001)
- Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis. Zhang, Y., Guan, R., Jiang, J., Kopchick, J.J., Black, R.A., Baumann, G., Frank, S.J. J. Biol. Chem. (2001)
- Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage. Cowan, J.W., Wang, X., Guan, R., He, K., Jiang, J., Baumann, G., Black, R.A., Wolfe, M.S., Frank, S.J. J. Biol. Chem. (2005)
- Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase. VanderKuur, J.A., Wang, X., Zhang, L., Campbell, G.S., Allevato, G., Billestrup, N., Norstedt, G., Carter-Su, C. J. Biol. Chem. (1994)
- Increased insulin-like growth factor 1 production by human osteoarthritic chondrocytes is not dependent on growth hormone action. Doré, S., Abribat, T., Rousseau, N., Brazeau, P., Tardif, G., DiBattista, J.A., Cloutier, J.M., Pelletier, J.P., Martel-Pelletier, J. Arthritis Rheum. (1995)
- Functional characterization of the alternatively spliced, placental human growth hormone receptor. Urbanek, M., Russell, J.E., Cooke, N.E., Liebhaber, S.A. J. Biol. Chem. (1993)
- A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization. Duquesnoy, P., Sobrier, M.L., Duriez, B., Dastot, F., Buchanan, C.R., Savage, M.O., Preece, M.A., Craescu, C.T., Blouquit, Y., Goossens, M. EMBO J. (1994)
- Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site. Wang, X., He, K., Gerhart, M., Huang, Y., Jiang, J., Paxton, R.J., Yang, S., Lu, C., Menon, R.K., Black, R.A., Baumann, G., Frank, S.J. J. Biol. Chem. (2002)
- Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation. Behncken, S.N., Billestrup, N., Brown, R., Amstrup, J., Conway-Campbell, B., Waters, M.J. J. Biol. Chem. (2000)
- Identification and cellular localization of growth hormone receptor gene expression in the human ovary. Sharara, F.I., Nieman, L.K. J. Clin. Endocrinol. Metab. (1994)
- The X-ray structure of a growth hormone-prolactin receptor complex. Somers, W., Ultsch, M., De Vos, A.M., Kossiakoff, A.A. Nature (1994)
- SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone. Carter-Su, C., Rui, L., Stofega, M.R. Recent Prog. Horm. Res. (2000)
- Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor. Schantl, J.A., Roza, M., De Jong, A.P., Strous, G.J. Biochem. J. (2003)
- Identification of novel sites in the ovine growth hormone receptor involved in binding hormone and conferring species specificity. Allan, G.J., Shand, J.H., Beattie, J., Flint, D.J. Eur. J. Biochem. (1999)
- Binding of human GM-CSF to synthetic peptides of the alpha subunit of its receptor. Di Bartolo, V., Danè, A., Cassano, E., Viganò, S., Chiello, E., Verniani, D., Beffy, P., Pegoraro, S., Hamdan, M., Rovero, P., Revoltella, R.P. J. Recept. Signal Transduct. Res. (1996)
- Growth-hormone signal transduction. Campbell, G.S. J. Pediatr. (1997)
- Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. Yi, W., Kim, S.O., Jiang, J., Park, S.H., Kraft, A.S., Waxman, D.J., Frank, S.J. Mol. Endocrinol. (1996)
- Treatment of IM-9 cells with human growth hormone (GH) promotes rapid disulfide linkage of the GH receptor. Frank, S.J., Gilliland, G., Van Epps, C. Endocrinology (1994)
- Human growth hormone fragments 1-43 and 44-191: in vitro somatogenic activity and receptor binding characteristics in human and nonprimate systems. Rowlinson, S.W., Waters, M.J., Lewis, U.J., Barnard, R. Endocrinology (1996)
- The role of GH receptor tyrosine phosphorylation in Stat5 activation. Hansen, J.A., Hansen, L.H., Wang, X., Kopchick, J.J., Gouilleux, F., Groner, B., Nielsen, J.H., Møldrup, A., Galsgaard, E.D., Billestrup, N. J. Mol. Endocrinol. (1997)
- New medical approaches in pituitary adenomas. Colao, A., Di Sarno, A., Marzullo, P., Di Somma, C., Cerbone, G., Landi, M.L., Faggiano, A., Merola, B., Lombardi, G. Horm. Res. (2000)
- Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. Cunha, K.S., Barboza, E.P., Da Fonseca, E.C. J. Clin. Pathol. (2003)
- A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency. Guevara-Aguirre, J., Vasconez, O., Martinez, V., Martinez, A.L., Rosenbloom, A.L., Diamond, F.B., Gargosky, S.E., Nonoshita, L., Rosenfeld, R.G. J. Clin. Endocrinol. Metab. (1995)
- Growth hormone is a human macrophage activating factor. Priming of human monocytes for enhanced release of H2O2. Warwick-Davies, J., Lowrie, D.B., Cole, P.J. J. Immunol. (1995)
- A novel C-terminal growth hormone receptor (GHR) mutation results in impaired GHR-STAT5 but normal STAT-3 signaling. Tiulpakov, A., Rubtsov, P., Dedov, I., Peterkova, V., Bezlepkina, O., Chrousos, G.P., Hochberg, Z. J. Clin. Endocrinol. Metab. (2005)
- The Growth Response to Growth Hormone (GH) Treatment in Children with Isolated GH Deficiency Is Independent of the Presence of the Exon 3-Minus Isoform of the GH Receptor. Blum, W.F., Machinis, K., Shavrikova, E.P., Keller, A., Stobbe, H., Pfaeffle, R.W., Amselem, S. J. Clin. Endocrinol. Metab. (2006)
- Growth hormone (GH) and prolactin receptors in human peripheral blood mononuclear cells: relation with age and GH-binding protein. Bresson, J.L., Jeay, S., Gagnerault, M.C., Kayser, C., Beressi, N., Wu, Z., Kinet, S., Dardenne, M., Postel-Vinay, M.C. Endocrinology (1999)
- A conformationally sensitive GHR [growth hormone (GH) receptor] antibody: impact on GH signaling and GHR proteolysis. Jiang, J., Wang, X., He, K., Li, X., Chen, C., Sayeski, P.P., Waters, M.J., Frank, S.J. Mol. Endocrinol. (2004)