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Disease relevance of Paratuberculosis


Psychiatry related information on Paratuberculosis


High impact information on Paratuberculosis

  • In particular, mouse models suggest TLR4 as a candidate gene for resistance to major agents in bovine respiratory disease and Johne's disease [7].
  • Sera from animals with Johne disease, but not sera from uninfected cattle, reacted with this lipopeptide, indicating potential biological importance [8].
  • This study used oligonucleotide primers to the species-specific M paratuberculosis IS900 DNA insertion element and the polymerase chain reaction to amplify any M paratuberculosis DNA from intestinal tissue DNA extracts [9].
  • Members of the 30- to 32-kilodalton mycolyl transferase family (Ag85) from culture filtrate of Mycobacterium avium subsp. paratuberculosis are immunodominant Th1-type antigens recognized early upon infection in mice and cattle [10].
  • The genes identified encode proteins that are similar to (i) M. tuberculosis coenzyme A carboxylase, (ii) M. tuberculosis membrane proteins of unknown function, (iii) M. tuberculosis FadE20, (iv) a Mycobacterium paratuberculosis surface protein, and (v) M. tuberculosis cyclopropane fatty acyl-phopholipid synthase [11].

Chemical compound and disease context of Paratuberculosis


Biological context of Paratuberculosis


Anatomical context of Paratuberculosis


Gene context of Paratuberculosis


Analytical, diagnostic and therapeutic context of Paratuberculosis


  1. Specific detection of Mycobacterium paratuberculosis by DNA hybridisation with a fragment of the insertion element IS900. Moss, M.T., Green, E.P., Tizard, M.L., Malik, Z.P., Hermon-Taylor, J. Gut (1991) [Pubmed]
  2. Antibodies to Mycobacterium paratuberculosis and nine species of environmental mycobacteria in Crohn's disease and control subjects. Stainsby, K.J., Lowes, J.R., Allan, R.N., Ibbotson, J.P. Gut (1993) [Pubmed]
  3. Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium. Hernandez Perez, M., Fomukong, N.G., Hellyer, T., Brown, I.N., Dale, J.W. Mol. Microbiol. (1994) [Pubmed]
  4. Mycobacterium paratuberculosis and Crohn's disease. Tanaka, K., Wilks, M., Coates, P.J., Farthing, M.J., Walker-Smith, J.A., Tabaqchali, S. Gut (1991) [Pubmed]
  5. In vivo administration of a monoclonal antibody against the type I IL-1 receptor inhibits the ability of mice to eliminate Mycobacterium paratuberculosis. Kenefick, K.B., Adams, J.L., Steinberg, H., Czuprynski, C.J. J. Leukoc. Biol. (1994) [Pubmed]
  6. Identification and characterization of a novel extracellular ferric reductase from Mycobacterium paratuberculosis. Homuth, M., Valentin-Weigand, P., Rohde, M., Gerlach, G.F. Infect. Immun. (1998) [Pubmed]
  7. Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain. White, S.N., Taylor, K.H., Abbey, C.A., Gill, C.A., Womack, J.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. A major cell wall lipopeptide of Mycobacterium avium subspecies paratuberculosis. Eckstein, T.M., Chandrasekaran, S., Mahapatra, S., McNeil, M.R., Chatterjee, D., Rithner, C.D., Ryan, P.W., Belisle, J.T., Inamine, J.M. J. Biol. Chem. (2006) [Pubmed]
  9. Mycobacterium paratuberculosis DNA not detected in Crohn's disease tissue by fluorescent polymerase chain reaction. Rowbotham, D.S., Mapstone, N.P., Trejdosiewicz, L.K., Howdle, P.D., Quirke, P. Gut (1995) [Pubmed]
  10. Members of the 30- to 32-kilodalton mycolyl transferase family (Ag85) from culture filtrate of Mycobacterium avium subsp. paratuberculosis are immunodominant Th1-type antigens recognized early upon infection in mice and cattle. Rosseels, V., Marché, S., Roupie, V., Govaerts, M., Godfroid, J., Walravens, K., Huygen, K. Infect. Immun. (2006) [Pubmed]
  11. Identification of Mycobacterium avium genes that affect invasion of the intestinal epithelium. Miltner, E., Daroogheh, K., Mehta, P.K., Cirillo, S.L., Cirillo, J.D., Bermudez, L.E. Infect. Immun. (2005) [Pubmed]
  12. Synthesis and biological evaluation of new acinetoferrin homologues for use as iron transport probes in mycobacteria. Gardner, R.A., Ghobrial, G., Naser, S.A., Phanstiel, O. J. Med. Chem. (2004) [Pubmed]
  13. Effects of gamma interferon and nitric oxide on the interaction of Mycobacterium avium subsp. paratuberculosis with bovine monocytes. Zhao, B., Collins, M.T., Czuprynski, C.J. Infect. Immun. (1997) [Pubmed]
  14. Activity of clarithromycin compared with those of other drugs against Mycobacterium paratuberculosis and further enhancement of its extracellular and intracellular activities by ethambutol. Rastogi, N., Goh, K.S., Labrousse, V. Antimicrob. Agents Chemother. (1992) [Pubmed]
  15. Effects of colonial morphology and tween 80 on antimicrobial susceptibility of Mycobacterium paratuberculosis. Van Boxtel, R.M., Lambrecht, R.S., Collins, M.T. Antimicrob. Agents Chemother. (1990) [Pubmed]
  16. Detection of Mycobacterium paratuberculosis by polymerase chain reaction in children with Crohn's disease. Dell'Isola, B., Poyart, C., Goulet, O., Mougenot, J.F., Sadoun-Journo, E., Brousse, N., Schmitz, J., Ricour, C., Berche, P. J. Infect. Dis. (1994) [Pubmed]
  17. Regulation of expression of major histocompatibility antigens by bovine macrophages infected with Mycobacterium avium subsp. paratuberculosis or Mycobacterium avium subsp. avium. Weiss, D.J., Evanson, O.A., McClenahan, D.J., Abrahamsen, M.S., Walcheck, B.K. Infect. Immun. (2001) [Pubmed]
  18. Persistence of Mycobacterium paratuberculosis during manufacture and ripening of cheddar cheese. Donaghy, J.A., Totton, N.L., Rowe, M.T. Appl. Environ. Microbiol. (2004) [Pubmed]
  19. Rapid differentiation of Mycobacterium avium and M. paratuberculosis by PCR and restriction enzyme analysis. Eriks, I.S., Munck, K.T., Besser, T.E., Cantor, G.H., Kapur, V. J. Clin. Microbiol. (1996) [Pubmed]
  20. Phagocytosis of M. paratuberculosis fails to activate expression of NADH dehydrogenase and nucleolin-related protein in bovine macrophages. Tooker, B.C., Coussens, P.M. Immunol. Lett. (2004) [Pubmed]
  21. Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein facilitates M-cell targeting and invasion through a fibronectin bridge with host integrins. Secott, T.E., Lin, T.L., Wu, C.C. Infect. Immun. (2004) [Pubmed]
  22. Study of T-lymphocyte subsets of healthy and Mycobacterium avium subsp. paratuberculosis-infected cattle. Bassey, E.O., Collins, M.T. Infect. Immun. (1997) [Pubmed]
  23. Evaluation of modified BACTEC 12B radiometric medium and solid media for culture of Mycobacterium avium subsp. paratuberculosis from sheep. Whittington, R.J., Marsh, I., McAllister, S., Turner, M.J., Marshall, D.J., Fraser, C.A. J. Clin. Microbiol. (1999) [Pubmed]
  24. Epitope shared by functional variant of organic cation/carnitine transporter, OCTN1, Campylobacter jejuni and Mycobacterium paratuberculosis may underlie susceptibility to Crohn's disease at 5q31. Lamhonwah, A.M., Ackerley, C., Onizuka, R., Tilups, A., Lamhonwah, D., Chung, C., Tao, K.S., Tellier, R., Tein, I. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  25. Mycobacterial cell wall components induce the production of TNF-alpha, IL-1, and IL-6 by bovine monocytes and the murine macrophage cell line RAW 264.7. Adams, J.L., Czuprynski, C.J. Microb. Pathog. (1994) [Pubmed]
  26. A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp paratuberculosis. Weiss, D.J., Evanson, O.A., de Souza, C., Abrahamsen, M.S. Am. J. Vet. Res. (2005) [Pubmed]
  27. Increased intestinal TNF-alpha, IL-1 beta and IL-6 expression in ovine paratuberculosis. Alzuherri, H.M., Woodall, C.J., Clarke, C.J. Vet. Immunol. Immunopathol. (1996) [Pubmed]
  28. Identification of a secreted superoxide dismutase in Mycobacterium avium ssp. paratuberculosis. Liu, X., Feng, Z., Harris, N.B., Cirillo, J.D., Bercovier, H., Barletta, R.G. FEMS Microbiol. Lett. (2001) [Pubmed]
  29. Effects of gamma interferon, interleukin-10, and transforming growth factor beta on the survival of Mycobacterium avium subsp. paratuberculosis in monocyte-derived macrophages from naturally infected cattle. Khalifeh, M.S., Stabel, J.R. Infect. Immun. (2004) [Pubmed]
  30. Duplex PCR for differential identification of Mycobacterium bovis, M. avium, and M. avium subsp. paratuberculosis in formalin- fixed paraffin-embedded tissues from cattle. Coetsier, C., Vannuffel, P., Blondeel, N., Denef, J.F., Cocito, C., Gala, J.L. J. Clin. Microbiol. (2000) [Pubmed]
  31. Characterization of Mycobacterium paratuberculosis by gas-liquid and thin-layer chromatography and rapid demonstration of mycobactin dependence using radiometric methods. Damato, J.J., Knisley, C., Collins, M.T. J. Clin. Microbiol. (1987) [Pubmed]
  32. Characterization of a specific Mycobacterium paratuberculosis recombinant clone expressing 35,000-molecular-weight antigen and reactivity with sera from animals with clinical and subclinical Johne's disease. El-Zaatari, F.A., Naser, S.A., Graham, D.Y. J. Clin. Microbiol. (1997) [Pubmed]
  33. Comparison of agar gel immunodiffusion and fecal culture for identification of goats with paratuberculosis. Sherman, D.M., Gezon, H.M. J. Am. Vet. Med. Assoc. (1980) [Pubmed]
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