Disease relevance of Adenoma, Villous

• Heterogeneous staining was found in villous adenomas with focal intramucosal adenocarcinoma but was negative in tubular adenomas, suggesting that expression of TA1/E16 may correlate with neoplastic progression in the colon [1].
• Genetic alterations in the mutation cluster region of the APC gene occurred significantly more frequently in large adenomas and showed a trend towards an increase in villous adenomas and adenomas with moderate and severe dysplasia [2].
• The p21 titers obtained from ulcerative colitis specimens were similar to those obtained from villous adenomas [3].
• Differences in p21 titer values among all classes of polyps were significant (hyperplastic polyps values were less than tubular adenomas values, which were less than villous adenoma values) [3].
• RESULTS: The mean levels of 12 kinds of urinary nucleosides (except uridine and guanosine) in the patients with colorectal cancer were significantly higher than those in patients with intestinal villous adenoma or the healthy adults [4].

High impact information on Adenoma, Villous

• Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma [5].
• In conclusion, PGE2 formation in the villous adenoma appears to be the cause of fluid secretion by the abnormal tumor epithelium [6].
• Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin [6].
• Biochemical and clinical evidence is presented to indicate that prostaglandin (PG)E2 is the mediator of fluid and electrolyte secretion by villous adenomas of the rectum [6].
• In normal colonic epithelium, villous adenomas, and differentiated adenocarcinomas, cingulin staining is observed in the junctional region of the polarized cells lining the surface, the crypts, and the glandular lumina [7].

Chemical compound and disease context of Adenoma, Villous

• Complete regression of villous adenomas of the colon using piroxicam, a nonsteroidal anti-inflammatory drug [8].
• A villous adenoma of the duodenum was studied histologically and histochemically by semi-thin sections using glycol-methacrylate as embedding medium [9].
• The effects of treatment with the synthetic long-acting somatostatin analogue SMS-201-995 were studied in a patient with a fluid and electrolyte secreting villous adenoma of the rectum [10].
• Consequently, we examined the effect of cholesterol levels on the occurrence of villous adenomas [11].
• Our data suggest that the massive diarrhea in our patient with a secretory villous adenoma may be related to increased adenylate cyclase activity [12].

Anatomical context of Adenoma, Villous

• An activated K-ras gene was also found in cell line S/AN, isolated from a sporadic villous adenoma [13].
• Lesser elevations in the amount of total glycosaminoglycans and hyaluronic acid and heparan sulfate were present in neonatal colonic mucosa, villous adenoma, ulcerative colitis, and mucosa adjacent to carcinoma [14].

Gene context of Adenoma, Villous

• It also remains unclear whether villous adenomas express cyclooxygenase-2 [15].
• Here we examined secreted mucins in tubular, tubulovillous and villous adenomas of the rectum using non-VNTR antibodies designed to assess mature mucin [16].
• Both CEA and SC expressions were found to be increased with the size of the adenomas, but only in the villous adenomas and not in the tubular adenomas [17].
• There was a tendency toward a higher serum CEA level in patients with villous adenoma as compared with those with tubular structure [18].
• A p53 gene mutation (GGC-->GAC at codon 245) was detected in two biopsies taken at a four year interval from a recurrent rectal villous adenoma [19].

References