The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CGN  -  cingulin

Homo sapiens

Synonyms: Cingulin, KIAA1319
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of CGN

 

High impact information on CGN

  • High-resolution immunofluorescence and SDS-PAGE analysis failed to reveal alterations of junctional proteins ZO-1, occludin, cingulin, and E-cadherin [6].
  • We characterized the sequence and protein interactions of cingulin, an M(r) 140-160-kD phosphoprotein localized on the cytoplasmic surface of epithelial tight junctions (TJ) [7].
  • The derived amino acid sequence of a full-length Xenopus laevis cingulin cDNA shows globular head (residues 1-439) and tail (1,326-1,368) domains and a central alpha-helical rod domain (440-1,325) [7].
  • We propose that cingulin is a functionally important component of TJ, linking the submembrane plaque domain of TJ to the actomyosin cytoskeleton [7].
  • Junctional plaque proteins without known functions include cingulin, p130, and 7H6; single reports describe ZA-1TJ and symplekin [8].
 

Chemical compound and disease context of CGN

 

Biological context of CGN

 

Anatomical context of CGN

 

Associations of CGN with chemical compounds

  • Here we show that GEF-H1/Lfc, a guanine nucleotide exchange factor for RhoA, directly interacts with cingulin, a junctional adaptor [11].
  • AGR codons became unassigned because of deletion of tRNA Arg (UCU) and elimination of AGR codons by conversion to CGN arginine codons [16].
  • For LDL susceptibility to oxidation LDL (oxLDL) by addition of Cu(2+), the lag time was approximately 57 min in healthy controls and CGN patients, but was prolonged to approximately 75 min in HD and DN patients [17].
  • The Tetrahymena mitochondrial code is analogous with the mammalian mitochondrial code; but differs from the Tetrahymena nuclear genetic code; TGA is exclusively translated as tryptophan; ATA is used as an initiation codon probably for methionine, and TAA as a stop codon; the arginine codons (CGN) are not used [18].
  • Propranolol was given to 10 hypertensive patients with CGN and hypotensive effect on renal function was observed [19].
 

Physical interactions of CGN

 

Regulatory relationships of CGN

  • Cingulin binding inhibits RhoA activation and signaling, suggesting that the increase in cingulin expression in confluent cells causes downregulation of RhoA by inhibiting GEF-H1/Lfc [11].
  • In vitro IFN-gamma synthesis was enhanced in patients with CGN, and NK cells were revealed to be responsible for such enhancement [15].
  • CD4-positive T cells from IgA nephritic patients expressed a higher level of TGF-beta mRNA than healthy controls (P < 0.01) but no difference was demonstrated on comparison with CGN patients [1].
 

Other interactions of CGN

  • Junctional adhesion molecule (JAM) is an integral membrane protein that has been reported to colocalize with the tight junction molecules occludin, ZO-1, and cingulin [13].
  • Nontransmembrane proteins on the cytosolic leaflet including ZO-1, ZO-2, cingulin, 7H6, and several unidentified phosphoproteins are also believed to be part of the TJ [21].
  • Cingulin, a protein component of the submembrane plaque of tight junctions (TJ), contains globular and coiled-coil domains and interacts in vitro with several TJ and cytoskeletal proteins, including the PDZ protein ZO-1 [14].
  • The highest numbers of glomerular CXCR1-positive cells were present in biopsies with MPGN, followed by lupus nephritis, and CGN [22].
  • These results suggest that impairment of regulation of the IFN-gamma system might be involved in the development of CGN [15].
 

Analytical, diagnostic and therapeutic context of CGN

References

  1. CD4-positive cells from patients with IgA nephropathy demonstrate increased mRNA of cytokines that induce the IgA switch and differentiation. Lai, K.N., Ho, R.T., Leung, J.C., Chui, Y.L., Lim, P.L., Lui, S.F., Li, P.K. J. Pathol. (1994) [Pubmed]
  2. Continuous ambulatory peritoneal dialysis: ten years at one facility. Rubin, J., Hsu, H. Am. J. Kidney Dis. (1991) [Pubmed]
  3. Impaired cell-mediated immunity in lipoid nephrosis. Matsumoto, K., Osakabe, K., Harada, M., Hatano, M. Nephron (1981) [Pubmed]
  4. Defective T-lymphocyte colony formation in patients with lupus nephritis. Matsumoto, K., Hatano, M. Journal of clinical & laboratory immunology. (1987) [Pubmed]
  5. Decreased T-colony formation by lymphocytes from patients with focal glomerular sclerosis. Matsumoto, K., Okano, K., Yoshizawa, N., Hatano, M. Int. Arch. Allergy Appl. Immunol. (1988) [Pubmed]
  6. Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin. Papini, E., Satin, B., Norais, N., de Bernard, M., Telford, J.L., Rappuoli, R., Montecucco, C. J. Clin. Invest. (1998) [Pubmed]
  7. Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin. Cordenonsi, M., D'Atri, F., Hammar, E., Parry, D.A., Kendrick-Jones, J., Shore, D., Citi, S. J. Cell Biol. (1999) [Pubmed]
  8. Molecular architecture of tight junctions. Mitic, L.L., Anderson, J.M. Annu. Rev. Physiol. (1998) [Pubmed]
  9. Lipoproteins and lipid peroxidation abnormalities in patients with chronic renal disease. Ong-Ajyooth, L., Ong-Ajyooth, S., Sirisalee, K., Nilwarangkur, S. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (1996) [Pubmed]
  10. Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly. Citi, S., D'Atri, F., Parry, D.A. J. Struct. Biol. (2000) [Pubmed]
  11. Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. Aijaz, S., D'Atri, F., Citi, S., Balda, M.S., Matter, K. Dev. Cell (2005) [Pubmed]
  12. Cell-cycle regulatory proteins in the podocyte in collapsing glomerulopathy in children. Srivastava, T., Garola, R.E., Singh, H.K. Kidney Int. (2006) [Pubmed]
  13. Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. Bazzoni, G., Martinez-Estrada, O.M., Orsenigo, F., Cordenonsi, M., Citi, S., Dejana, E. J. Biol. Chem. (2000) [Pubmed]
  14. Evidence for a functional interaction between cingulin and ZO-1 in cultured cells. D'Atri, F., Nadalutti, F., Citi, S. J. Biol. Chem. (2002) [Pubmed]
  15. Altered synthesis of interferon-gamma and expression of interferon-gamma receptor by peripheral blood mononuclear cells from patients with IgA nephropathy and non-IgA proliferative glomerulonephritis. Yano, N., Endoh, M., Naka, R., Takemura, F., Nomoto, Y., Sakai, H. J. Clin. Immunol. (1996) [Pubmed]
  16. Evolution of the mitochondrial genetic code. I. Origin of AGR serine and stop codons in metazoan mitochondria. Osawa, S., Ohama, T., Jukes, T.H., Watanabe, K. J. Mol. Evol. (1989) [Pubmed]
  17. Serum lipid metabolism abnormalities and change in lipoprotein contents in patients with advanced-stage renal disease. Tsumura, M., Kinouchi, T., Ono, S., Nakajima, T., Komoda, T. Clin. Chim. Acta (2001) [Pubmed]
  18. The cytochrome oxidase subunit I gene of Tetrahymena: a 57 amino acid NH2-terminal extension and a 108 amino acid insert. Ziaie, Z., Suyama, Y. Curr. Genet. (1987) [Pubmed]
  19. Therapy and prognosis of hypertension in chronic nephritis. Kajiwara, N. Jpn. Circ. J. (1975) [Pubmed]
  20. The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus. Pernet-Gallay, K., Antony, C., Johannes, L., Bornens, M., Goud, B., Rios, R.M. Traffic (2002) [Pubmed]
  21. Molecular structure and assembly of the tight junction. Denker, B.M., Nigam, S.K. Am. J. Physiol. (1998) [Pubmed]
  22. Expression of the chemokine receptor CXCR1 in human glomerular diseases. Segerer, S., Henger, A., Schmid, H., Kretzler, M., Draganovici, D., Brandt, U., Noessner, E., Nelson, P.J., Kerjaschki, D., Schlöndorff, D., Regele, H. Kidney Int. (2006) [Pubmed]
  23. Apoptosis, proliferation and inflammatory infiltration in ANCA-positive glomerulonephritis. Kettritz, R., Wilke, S., von Vietinghoff, S., Luft, F., Schneider, W. Clin. Nephrol. (2006) [Pubmed]
 
WikiGenes - Universities