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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Taste Threshold

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Disease relevance of Taste Threshold


Psychiatry related information on Taste Threshold

  • Olfaction rather than taste was involved in the conditioned response to L-proline because the highest possible contact concentration (3 x 10(-6) M) of L-proline within the stimulus eddies was at least 30 times lower than the estimated L-proline electrophysiological taste threshold (> 10(-4) M) [4].

High impact information on Taste Threshold


Anatomical context of Taste Threshold

  • To characterize the key compounds imparting this cooling sensation to the oral cavity, a taste dilution analysis was performed by determining the taste threshold of reaction products in serial dilutions of HPLC fractions to select the most intense "cooling" compounds in the complex GPC fraction of the Maillard reaction mixture [10].

Associations of Taste Threshold with chemical compounds


Gene context of Taste Threshold

  • Striking racial differences are observed in the plasma and intracellular electrolytes, cation transmembrane transport, salt taste threshold, plasma renin activity and urinary kallikrein activity [15].
  • No diminution in taste sensitivity to PTC was found with increasing age although a significant difference in PTC taste thresholds was found between males and females [16].


  1. Alterations in taste thresholds in men with chronic obstructive pulmonary disease. Chapman-Novakofski, K., Brewer, M.S., Riskowski, J., Burkowski, C., Winter, L. Journal of the American Dietetic Association. (1999) [Pubmed]
  2. Reduction of sodium taste threshold during treatment with captopril in essential hypertension. Fyhrquist, F., Grönhagen-Riska, C., Saloranta, K. Acta Med. Scand. Suppl. (1983) [Pubmed]
  3. Sucrose taste thresholds and dental caries: implications for dietary counseling. Catalanotto, F.A., Wrobel, W.R., Epstein, D.W. Clinical preventive dentistry. (1979) [Pubmed]
  4. Chemical and visual control of feeding and escape behaviors in the channel catfish Ictalurus punctatus. Valentincic, T.B., Caprio, J. Physiol. Behav. (1994) [Pubmed]
  5. Bitter taste of saccharin related to the genetic ability to taste the bitter substance 6-n-propylthiouracil. Bartoshuk, L.M. Science (1979) [Pubmed]
  6. Role of zinc supplementation in type II diabetes mellitus. Niewoehner, C.B., Allen, J.I., Boosalis, M., Levine, A.S., Morley, J.E. Am. J. Med. (1986) [Pubmed]
  7. Altered taste sensation in newly-diagnosed NIDDM. Perros, P., MacFarlane, T.W., Counsell, C., Frier, B.M. Diabetes Care (1996) [Pubmed]
  8. The effect of age on plasma zinc uptake and taste acuity. Bales, C.W., Steinman, L.C., Freeland-Graves, J.H., Stone, J.M., Young, R.K. Am. J. Clin. Nutr. (1986) [Pubmed]
  9. Interaction of saliva and taste. Spielman, A.I. J. Dent. Res. (1990) [Pubmed]
  10. Characterization of natural "cooling" compounds formed from glucose and l-proline in dark malt by application of taste dilution analysis. Ottinger, H., Bareth, A., Hofmann, T. J. Agric. Food Chem. (2001) [Pubmed]
  11. Taste thresholds in man are differentially influenced by hydrocortisone and dexamethasone. Fehm-Wolfsdorf, G., Scheible, E., Zenz, H., Born, J., Fehm, H.L. Psychoneuroendocrinology (1989) [Pubmed]
  12. Sucrose and Monosodium Glutamate Taste Thresholds and Discrimination Ability of T1R3 Knockout Mice. Delay, E.R., Hernandez, N.P., Bromley, K., Margolskee, R.F. Chem. Senses (2006) [Pubmed]
  13. Changes in taste threshold over the life span of the Sprague-Dawley rat. Thaw, A.K. Chem. Senses (1996) [Pubmed]
  14. Determination of the taste threshold of copper in water. Zacarías, I., Yáñez, C.G., Araya, M., Oraka, C., Olivares, M., Uauy, R. Chem. Senses (2001) [Pubmed]
  15. The relative importance of genetic and environmental factors in hypertension in black subjects. Aderounmu, A.F. Clinical and experimental hypertension. (1981) [Pubmed]
  16. Population genetic models in the study of aging and longevity in a Mennonite community. Crawford, M.H., Rogers, L. Social science & medicine (1982) (1982) [Pubmed]
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