The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hyperopia


Psychiatry related information on Hyperopia

  • First, there is need for further investigation of 1) the role of culture in determining visual performance and 2) the relationship of visual performance patterns to social behavior, beyond that which has already been done, for example, with myopia and hyperopia [6].
  • Soldiers wit abnormal stereopsis, myopia, hyperopia more than 1.75, or astigmatism over 0.50 diopters, were omitted [7].

High impact information on Hyperopia

  • Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein [2].
  • A cloned copy of the gene will enable examination of the relationship, if any, between nanophthalmos and less severe forms of hyperopia and between nanophthalmos and other conditions in which angle-closure glaucoma is a feature [3].
  • In patients with intact lenses the vision became more myopic or less hyperopic following the administration of glucose, but in the aphakic eyes hyperopia increased [8].
  • Older individuals had shallower ACDs, thicker lenses, more NOP, and more hyperopia compared to younger individuals (P < 0.001) [9].
  • Genetic effects are of major importance in myopia/hyperopia; astigmatism appears to be dominantly inherited [10].

Chemical compound and disease context of Hyperopia


Anatomical context of Hyperopia

  • Twelve month postoperative data were obtained on 25 eyes with refractions of +1.00 to +4.00 diopters (D) that had been treated for hyperopia with the VISX Star excimer laser, using blunt scrape or the rotary brush to remove the corneal epithelium [15].
  • AIM: To evaluate the accuracy and reliability of the optical versus ultrasonic measurement of anterior chamber depth (ACD) in a group of patients affected by high myopia or hyperopia, before phakic IOL implant [16].
  • The occurrence of a defect (nerve fiber loss) in the retinal nerve fiber layer in severe myopia (5/59, 8%) was also greater than that in either emmetropia or hyperopia (2/144, 1%; P = 0.0229) [17].
  • Multifocal lenses and surgically induced multifocal corneas have the potential to eliminate not only myopia and hyperopia but also the loss of accommodation resulting from the pseudophakic state [18].

Gene context of Hyperopia


Analytical, diagnostic and therapeutic context of Hyperopia


  1. The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein. Pusch, C.M., Zeitz, C., Brandau, O., Pesch, K., Achatz, H., Feil, S., Scharfe, C., Maurer, J., Jacobi, F.K., Pinckers, A., Andreasson, S., Hardcastle, A., Wissinger, B., Berger, W., Meindl, A. Nat. Genet. (2000) [Pubmed]
  2. Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein. Sundin, O.H., Leppert, G.S., Silva, E.D., Yang, J.M., Dharmaraj, S., Maumenee, I.H., Santos, L.C., Parsa, C.F., Traboulsi, E.I., Broman, K.W., Dibernardo, C., Sunness, J.S., Toy, J., Weinberg, E.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Autosomal dominant nanophthalmos (NNO1) with high hyperopia and angle-closure glaucoma maps to chromosome 11. Othman, M.I., Sullivan, S.A., Skuta, G.L., Cockrell, D.A., Stringham, H.M., Downs, C.A., Fornés, A., Mick, A., Boehnke, M., Vollrath, D., Richards, J.E. Am. J. Hum. Genet. (1998) [Pubmed]
  4. Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. Brown, D.J., Kim, T.B., Petty, E.M., Downs, C.A., Martin, D.M., Strouse, P.J., Moroi, S.E., Milunsky, J.M., Lesperance, M.M. Am. J. Hum. Genet. (2002) [Pubmed]
  5. Refractive errors in an urban population in Southern India: the Andhra Pradesh Eye Disease Study. Dandona, R., Dandona, L., Naduvilath, T.J., Srinivas, M., McCarty, C.A., Rao, G.N. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  6. Culture and the development of vision. Carr, W.K., Francke, A.W. Journal of the American Optometric Association. (1976) [Pubmed]
  7. On the significance of heterophoria for stereoscopic vision. Castrén, J., Rutanen, H., Aho, J. Aviation, space, and environmental medicine. (1982) [Pubmed]
  8. Relationship of serum glucose concentration to changes in refraction. Gwinup, G., Villarreal, A. Diabetes (1976) [Pubmed]
  9. Refractive error, ocular biometry, and lens opalescence in an adult population: the Los Angeles Latino Eye Study. Shufelt, C., Fraser-Bell, S., Ying-Lai, M., Torres, M., Varma, R. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  10. Genes and environment in refractive error: the twin eye study. Hammond, C.J., Snieder, H., Gilbert, C.E., Spector, T.D. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  11. Effects of nicotinic antagonists on ocular growth and experimental myopia. Stone, R.A., Sugimoto, R., Gill, A.S., Liu, J., Capehart, C., Lindstrom, J.M. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  12. Cycloplegic refraction in esotropic children. Cyclopentolate versus atropine. Rosenbaum, A.L., Bateman, J.B., Bremer, D.L., Liu, P.Y. Ophthalmology (1981) [Pubmed]
  13. Hyperopia correction by noncontact holmium:YAG laser thermal keratoplasty. Clinical study with two-year follow-up. Koch, D.D., Abarca, A., Villarreal, R., Menefee, R., Kohnen, T., Vassiliadis, A., Berry, M. Ophthalmology (1996) [Pubmed]
  14. Long-term results of multizone photorefractive keratectomy for myopia of -6.0 to -10.0 diopters. Keskinbora, H.K. Journal of cataract and refractive surgery. (2000) [Pubmed]
  15. Evaluation of current techniques of corneal epithelial removal in hyperopic photorefractive keratectomy. Griffith, M., Jackson, W.B., Lafontaine, M.D., Mintsioulis, G., Agapitos, P., Hodge, W. Journal of cataract and refractive surgery. (1998) [Pubmed]
  16. Anterior chamber depth measured by two methods in myopic and hyperopic phakic IOL implant. Vetrugno, M., Cardascia, N., Cardia, L. The British journal of ophthalmology. (2000) [Pubmed]
  17. Apparent cleavage of the retinal nerve fiber layer in asymptomatic eyes with high myopia. Chihara, E., Chihara, K. Graefes Arch. Clin. Exp. Ophthalmol. (1992) [Pubmed]
  18. Refractive aspects of cataract surgery. Fine, I.H., Hoffman, R.S. Current opinion in ophthalmology. (1996) [Pubmed]
  19. A G1103R mutation in CRB1 is co-inherited with high hyperopia and Leber congenital amaurosis. Abouzeid, H., Li, Y., Maumenee, I.H., Dharmaraj, S., Sundin, O. Ophthalmic Genet. (2006) [Pubmed]
  20. Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness. Bech-Hansen, N.T., Naylor, M.J., Maybaum, T.A., Pearce, W.G., Koop, B., Fishman, G.A., Mets, M., Musarella, M.A., Boycott, K.M. Nat. Genet. (1998) [Pubmed]
  21. Spatial localization in esotropia: does extraretinal eye position information change? Weir, C.R., Cleary, M., Parks, S., Dutton, G.N. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  22. Clear lens extraction with intraocular lens followed by photorefractive keratectomy or laser in situ keratomileusis. Pop, M., Payette, Y., Amyot, M. Ophthalmology (2001) [Pubmed]
  23. Hyperopia correction by noncontact holmium:YAG laser thermal keratoplasty. United States phase IIA clinical study with a 1-year follow-up. Koch, D.D., Kohnen, T., McDonnell, P.J., Menefee, R.F., Berry, M.J. Ophthalmology (1996) [Pubmed]
  24. Photorefractive keratectomy to correct astigmatism with myopia or hyperopia. Dausch, D., Klein, R., Landesz, M., Schröder, E. Journal of cataract and refractive surgery. (1994) [Pubmed]
  25. Clear lens extraction with intraocular lens implantation for hyperopia. Preetha, R., Goel, P., Patel, N., Agarwal, S., Agarwal, A., Agarwal, J., Agarwal, T., Agarwal, A. Journal of cataract and refractive surgery. (2003) [Pubmed]
  26. Surgically induced astigmatism after hyperopic and myopic photorefractive keratectomy. Yi, D.H., Petroll, M., Bowman, R.W., McCulley, J.P., Cavanagh, H.D. Journal of cataract and refractive surgery. (2001) [Pubmed]
  27. High-frequency ultrasound biomicroscopy of silicone posterior chamber phakic intraocular lens for hyperopia. García-Feijoó, J., Hernández-Matamoros, J.L., Castillo-Gómez, A., Lázaro, C., Méndez-Hernández, C., Martín, T., Martínez de la Casa, J.M., García-Sánchez, J. Journal of cataract and refractive surgery. (2003) [Pubmed]
WikiGenes - Universities