Disease relevance of Ganglionectomy

• Furthermore, the increases in levels of serum-derived proteins, histamine, and influx of cells (especially neutrophils) observed in BALF after anaphylaxis were attenuated by both decentralization and ganglionectomy [1].
• Chronic trigeminal ganglionectomy or topical capsaicin application to pial vessels attenuates postocclusive cortical hyperemia but does not influence postischemic hypoperfusion [2].
• The response of serum PTH to a hypocalcemia produced by EDTA injection, and of serum calcitonin to a hypercalcemia produced by administering calcium chloride, were studied in rats at the time of the wallerian degeneration of regional sympathetic nerves (i.e., 16 hr after superior cervical ganglionectomy, SCGx) [3].
• Increased [(3)H] PK11195 binding (a known marker of reactive gliosis) was also observed in the same brainstem nuclei as non-angiotensin II [(125)I] CGP42112 binding after nodose ganglionectomy [4].
• Nerve section with or without ganglionectomy and experiments involving the neonatal administration of capsaicin indicate that the CGRP-immunoreactive fibers in the carotid body come from the glossopharyngeal, vagal and spinal sensory ganglia, although those from the glossopharyngeal ganglion are predominant [5].

High impact information on Ganglionectomy

• Ganglionectomy alone did not alter the incremental protein response to any load of tryptophan [6].
• Pretreatment with reserpine or splanchnic ganglionectomy converted the thermally induced decline in mesenteric blood flow into a vasodilator response, which could then be blocked by an antiserum to substance P [7].
• After a trial of conventional modalities of treatment including left stellate ganglionectomy, primidone (Mysoline) therapy was initiated [8].
• The vasodilator response to acetylcholine was unaffected by trigeminal ganglionectomy [9].
• In cats subjected to chronic unilateral trigeminal ganglionectomy, the vasodilator responses to nitroprusside and nitroglycerin were markedly depressed on the denervated side [9].

Chemical compound and disease context of Ganglionectomy

• Bilateral stellate ganglionectomy prevented the tachycardia and reduced the pressor response to the lower dose (15 mug) of ouabain; bilateral adrenalectomy only reduced the pressor effect [10].
• The effects of different doses and time of administration of the N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801) on the development of the autotomy (self-mutilation) were studied in the rats receiving dorsal root ganglionectomy (DRGn) [11].
• Superior cervical ganglionectomy differentially modifies median eminence and anterior and mediobasal hypothalamic GABA content in male rats: effects of hyperprolactinemia [12].
• The persisting secretory response after otic ganglionectomy, exaggerated due to sensitization, and the residual acetylcholine synthesizing capacity (mainly depending on the facial nerve) showed that a minor proportion of pre- and postganglionic nerve fibres relay outside the otic ganglion [13].
• The efficacy of pinealectomy and ganglionectomy in provoking luteinization was inversely related to the dose of testosterone used for neonatal androgenization [14].

Biological context of Ganglionectomy

• Immunization significantly increased mesor values of splenic tyrosine hydroxylase activity, whereas neither pinealectomy nor superior cervical ganglionectomy affected circadian rhythm parameters [15].
• Timolol did not lower intraocular pressure when applied during the dark to animals after cervical ganglionectomy [16].
• We have previously shown that following unilateral nodose ganglionectomy, [125I] CGP42112 binds to a non-angiotensin II (Ang II) related binding site in rat dorsal motor nucleus of the vagus nerve, ambiguus nucleus and nucleus of the solitary tract [17].
• In this report, the suicide axoplasmic transport of adriamycin is described as a novel approach to sensory ganglionectomy [18].
• The inhibitory effect of CRF on solid gastric emptying was significantly blocked by guanethidine, propranolol, and celiac ganglionectomy but not by phentolamine [19].

Anatomical context of Ganglionectomy

• The response was mediated over the sympathetic nervous system since it was blocked by stellate ganglionectomy and by the alpha 1-adrenergic receptor antagonist prazosin [20].
• This effect was abolished by the intrahypothalamic injection of the beta-adrenoreceptor blocker, propranolol, and by chemical sympathectomy of the hypothalamus or of the upper brainstem with 6-hydroxydopamine, but was not altered by bilateral cervical ganglionectomy [21].
• With the vagus nerves intact, ganglionectomy alone had no effect on the integrated plasma gastrin response whether or not atropine was given [22].
• Circannual oscillations of thyroxine and cholesterol levels after pinealectomy and ganglionectomy related to the weight changes of the pineal, pituitary, and thyroid glands [23].
• In the current study, aqueous humor NE after superior cervical ganglionectomy was extracted and quantified using high-performance liquid chromatography-electrochemical detection [24].

Associations of Ganglionectomy with chemical compounds

• In the growing group, 8 weeks after ganglionectomy, the denervated arteries showed mean decreases in tissue weight (11%), total wall thickness (12+), cross-sectional area of media (17%), contractility (16%), and increases in the tangential modulus of elasticity and sensitivity to NE (2.3-fold) compared to the contralateral control vessels [25].
• However, this pressor response could be counteracted by intravenous propranolol (n = 5) or by bilateral stellate ganglionectomy (n = 3) [26].
• The 5-HT-mediated effect on inositol phosphates is unaffected by superior cervical ganglionectomy [27].
• The effect of noradrenaline, which also stimulates inositol phosphate accumulation (but via alpha 1-adrenergic receptors in the iris-ciliary body), was elevated following superior cervical ganglionectomy [27].
• There was no effect of coeliac ganglionectomy on pancreatic response to ethanol 1 g/kg [28].

Gene context of Ganglionectomy

• Nearly all the TH- and NPY-immunoreactive nerve fibres in the superficial pineal gland disappeared after bilateral superior cervical ganglionectomy, showing that the majority of NPY- and TH-immunoreactive nerve fibres belonged to the sympathetic nervous system [29].
• Celiac ganglionectomy did not affect substance P-like immunoreactivity, or NK1 or NK2 receptor binding [30].
• Acetylcholine levels and choline acetyltransferase activity in rat cerebrovascular bed after uni- or bilateral sphenopalatine ganglionectomy [31].
• Uni- or bilateral superior cervical ganglionectomies for 1-4 weeks resulted in a complete disappearance of tyrosine hydroxylase immunoreactivity in the glandular parenchyma, while moderate tyrosine hydroxylase immunoreactivity was seen in some neurons of the submandibular ganglia [32].
• The brains of these transgenic mice were found to contain postganglionic sympathetic fibers, as identified by their immunohistochemical staining for tyrosine hydroxylase and by their disappearance following superior cervical ganglionectomy [33].

Analytical, diagnostic and therapeutic context of Ganglionectomy

• Ventriculocisternal perfusion of clonidine (0.1 micrograms/min) in rabbits with unilateral superior cervical ganglionectomy lowered IOP in both eyes, indicating that ocular adrenergic innervation does not participate in this centrally mediated IOP response [34].
• 2. Reflex pathways were acutely interrupted by either subdiaphragmatic vagotomy or prevertebral ganglionectomy [35].
• Standard electron microscopic techniques as well as calcitonin-gene-related peptide (CGRP) immunohistochemistry at the light microscopic level were used to examine the effects of intracerebroventricular NGF infusion on mature perivascular fibers with and without prior sympathetic denervation (i.e., bilateral superior cervical ganglionectomy) [36].
• The density of alpha 2-adrenoceptor binding sites and the content of substance P, enkephalins, and neurotensin were determined in quadrants of the lumbar spinal enlargement of control cats and of cats upon which either unilateral dorsal root ganglionectomies or unilateral ventral rhizotomies had been performed [37].
• We used microdissection combined with a fluorometric assay to measure glutaminase activity in the vestibular nerve root and nuclei of rats with unilateral vestibular ganglionectomy [38].

References