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Gene Review

CCL17  -  chemokine (C-C motif) ligand 17

Homo sapiens

Synonyms: A-152E5.3, ABCD-2, C-C motif chemokine 17, CC chemokine TARC, SCYA17, ...
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Disease relevance of CCL17


High impact information on CCL17


Chemical compound and disease context of CCL17


Biological context of CCL17


Anatomical context of CCL17


Associations of CCL17 with chemical compounds

  • Although both CCL17 and CCL22 caused mobilization of intracellular calcium, none of them induced migration or histamine release [20].
  • Roxithromycin (RXM), a 14-membered ring macrolide, suppressed CCL17 production by HaCaT KC induced by IFNgamma and TNFalpha [21].
  • Surprisingly, an inhibitor of epidermal growth factor receptor tyrosine kinase, PD153035, enhanced the production of CCL17 in HaCaT KC [21].
  • Inhibitors for nuclear factor kappa B (NFkappaB), parthenolide, and Bay 11-7085, and an inhibitor of p38, SB202190, inhibited TNFalpha- and IFNgamma-induced production of CCL17 by HaCaT KC [21].
  • However, after E(2) pretreatment the lipopolysaccharide (LPS)-induced production of MCP-1, TARC, and MDC by DCs was clearly enhanced [22].

Physical interactions of CCL17


Regulatory relationships of CCL17

  • OBJECTIVE: We sought to determine whether transforming growth factor-beta 1 (TGF-beta 1) regulated TARC expression in keratinocytes [25].
  • IFN-gamma further enhanced the IL-4+TNF-alpha or IL-13+TNF-alpha-induced TARC production in the fibroblasts [26].
  • Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo [27].
  • To determine whether polymorphisms of the IL-4Ralpha have an impact on the ability of IL-13 or IL-4 to induce TARC release, HASM cells from multiple donors were genotyped for the Ile50Val, Ser478Pro, and Gln551Arg polymorphisms of the IL-4Ralpha [28].
  • T-cell-directed chemokine thymus- and activation-regulated chemokine (TARC)- and/or macrophage-derived chemokine (MDC)-positive H&RS cells were detected in all 20 cases of HL MC and HL NS but only in 5 of 9 cases of HL-like ATLL [29].

Other interactions of CCL17

  • Viral macrophage inflammatory protein (vMIP)-I, I-309, and TARC competed with the binding of (125)I-309 to AD cells with varying affinities [30].
  • K562 cells stably expressing CCR4 also responded to TARC in a calcium mobilization assay [31].
  • Thymus and activation-regulated chemokine (TARC) is a recently identified CC chemokine that is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells [31].
  • Systemic CXCL9 levels decreased from pre- to grass pollen season in allergics (P < 0.05), whereas CCL17 decreased in non-allergics (P < 0.05) over the same period [32].
  • There was no correlation between plasma levels of MCP-1/CCL2 and TARC/CCL17 [33].

Analytical, diagnostic and therapeutic context of CCL17

  • Furthermore, serum CCL17 and CXCL10 levels varied between AML patients and were determined by disease status (both chemokines) as well as patient age, chemotherapy and complicating infections (only CCL17) [34].
  • METHODS: We measured plasma levels of CCL17, CCL22, IFNgamma, IL-12 and IL-18 in 15 patients with AD before and after treatment with oral Olopatadine (10 mg/day) for 4 weeks [35].
  • Furthermore, we detected strong signals for CCR4, TARC, and MDC in ATL skin lesions by RT-PCR [36].
  • We could not find any significant relationship of IP-10, Mig, I-TAC and TARC gene expression with disease-free survival or lower risk of recurrence after surgery [37].
  • Peak expression of CCL22 preceded the peak levels of CCL17, as measured by real-time quantitative PCR [8].


  1. Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus. Nakayama, T., Hieshima, K., Nagakubo, D., Sato, E., Nakayama, M., Kawa, K., Yoshie, O. J. Virol. (2004) [Pubmed]
  2. Role of the chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine/CCL17 for lymphocyte recruitment in cutaneous lupus erythematosus. Wenzel, J., Henze, S., Wörenkämper, E., Basner-Tschakarjan, E., Sokolowska-Wojdylo, M., Steitz, J., Bieber, T., Tüting, T. J. Invest. Dermatol. (2005) [Pubmed]
  3. CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis. Inoue, T., Fujishima, S., Ikeda, E., Yoshie, O., Tsukamoto, N., Aiso, S., Aikawa, N., Kubo, A., Matsushima, K., Yamaguchi, K. Eur. Respir. J. (2004) [Pubmed]
  4. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. Ying, S., O'Connor, B., Ratoff, J., Meng, Q., Mallett, K., Cousins, D., Robinson, D., Zhang, G., Zhao, J., Lee, T.H., Corrigan, C. J. Immunol. (2005) [Pubmed]
  5. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Campbell, J.J., Haraldsen, G., Pan, J., Rottman, J., Qin, S., Ponath, P., Andrew, D.P., Warnke, R., Ruffing, N., Kassam, N., Wu, L., Butcher, E.C. Nature (1999) [Pubmed]
  6. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. Iellem, A., Mariani, M., Lang, R., Recalde, H., Panina-Bordignon, P., Sinigaglia, F., D'Ambrosio, D. J. Exp. Med. (2001) [Pubmed]
  7. Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. Yoneyama, H., Harada, A., Imai, T., Baba, M., Yoshie, O., Zhang, Y., Higashi, H., Murai, M., Asakura, H., Matsushima, K. J. Clin. Invest. (1998) [Pubmed]
  8. The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis. Belperio, J.A., Dy, M., Murray, L., Burdick, M.D., Xue, Y.Y., Strieter, R.M., Keane, M.P. J. Immunol. (2004) [Pubmed]
  9. Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis. Fujisawa, T., Fujisawa, R., Kato, Y., Nakayama, T., Morita, A., Katsumata, H., Nishimori, H., Iguchi, K., Kamiya, H., Gray, P.W., Chantry, D., Suzuki, R., Yoshie, O. J. Allergy Clin. Immunol. (2002) [Pubmed]
  10. Interleukin-8 secretion by cultured oral epidermoid carcinoma cells induced with nicotine and/or arecoline treatments. Cheng, Y.A., Shiue, L.F., Yu, H.S., Hsieh, T.Y., Tsai, C.C. The Kaohsiung journal of medical sciences. (2000) [Pubmed]
  11. Computed tomography scanning findings associated with rapid expansion of abdominal aortic aneurysms. Wolf, Y.G., Thomas, W.S., Brennan, F.J., Goff, W.G., Sise, M.J., Bernstein, E.F. J. Vasc. Surg. (1994) [Pubmed]
  12. Common and differential chemokine expression patterns in rs cells of NLP, EBV positive and negative classical Hodgkin lymphomas. Maggio, E.M., Van Den Berg, A., Visser, L., Diepstra, A., Kluiver, J., Emmens, R., Poppema, S. Int. J. Cancer (2002) [Pubmed]
  13. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. Imai, T., Chantry, D., Raport, C.J., Wood, C.L., Nishimura, M., Godiska, R., Yoshie, O., Gray, P.W. J. Biol. Chem. (1998) [Pubmed]
  14. Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. Bochner, B.S., Hudson, S.A., Xiao, H.Q., Liu, M.C. J. Allergy Clin. Immunol. (2003) [Pubmed]
  15. TARC and MDC are produced by CD40 activated human B cells and are elevated in the sera of infantile atopic dermatitis patients. Lin, L., Nonoyama, S., Oshiba, A., Kabasawa, Y., Mizutani, S. J. Med. Dent. Sci. (2003) [Pubmed]
  16. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. Cavassani, K.A., Campanelli, A.P., Moreira, A.P., Vancim, J.O., Vitali, L.H., Mamede, R.C., Martinez, R., Silva, J.S. J. Immunol. (2006) [Pubmed]
  17. Cutting edge: differential chemokine production by myeloid and plasmacytoid dendritic cells. Penna, G., Vulcano, M., Roncari, A., Facchetti, F., Sozzani, S., Adorini, L. J. Immunol. (2002) [Pubmed]
  18. Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice. Vestergaard, C., Deleuran, M., Gesser, B., Larsen, C.G. Exp. Dermatol. (2004) [Pubmed]
  19. Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Gear, A.R., Camerini, D. Microcirculation (New York, N.Y. : 1994) (2003) [Pubmed]
  20. CCL17 and CCL22 attenuate CCL5-induced mast cell migration. Juremalm, M., Olsson, N., Nilsson, G. Clin. Exp. Allergy (2005) [Pubmed]
  21. Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin. Komine, M., Kakinuma, T., Kagami, S., Hanakawa, Y., Hashimoto, K., Tamaki, K. J. Invest. Dermatol. (2005) [Pubmed]
  22. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Bengtsson, A.K., Ryan, E.J., Giordano, D., Magaletti, D.M., Clark, E.A. Blood (2004) [Pubmed]
  23. Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector. Imai, T., Yoshida, T., Baba, M., Nishimura, M., Kakizaki, M., Yoshie, O. J. Biol. Chem. (1996) [Pubmed]
  24. High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltratein Hodgkin's lymphoma. van den Berg, A., Visser, L., Poppema, S. Am. J. Pathol. (1999) [Pubmed]
  25. TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha-induced TARC (CCL17) production in HaCaT cells. Sumiyoshi, K., Nakao, A., Setoguchi, Y., Tsuboi, R., Okumura, K., Ogawa, H. J. Dermatol. Sci. (2003) [Pubmed]
  26. Differential regulation of thymus- and activation-regulated chemokine induced by IL-4, IL-13, TNF-alpha and IFN-gamma in human keratinocyte and fibroblast. Yu, B., Koga, T., Urabe, K., Moroi, Y., Maeda, S., Yanagihara, Y., Furue, M. J. Dermatol. Sci. (2002) [Pubmed]
  27. Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo. de Lavareille, A., Roufosse, F., Schandené, L., Stordeur, P., Cogan, E., Goldman, M. Eur. J. Immunol. (2001) [Pubmed]
  28. IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype. Faffe, D.S., Whitehead, T., Moore, P.E., Baraldo, S., Flynt, L., Bourgeois, K., Panettieri, R.A., Shore, S.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  29. Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma: classical Hodgkin lymphoma vs. Hodgkin-like ATLL. Ohshima, K., Karube, K., Hamasaki, M., Suefuji, H., Tutiya, T., Yamaguchi, T., Suzumiya, J., Kikuchi, M. Int. J. Cancer (2003) [Pubmed]
  30. Expression and regulation of chemokine receptors in human natural killer cells. Inngjerdingen, M., Damaj, B., Maghazachi, A.A. Blood (2001) [Pubmed]
  31. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., Yoshie, O. J. Biol. Chem. (1997) [Pubmed]
  32. Systemic chemokine and chemokine receptor responses are divergent in allergic versus non-allergic humans. Campbell, J.D., Stinson, M.J., Simons, F.E., HayGlass, K.T. Int. Immunol. (2002) [Pubmed]
  33. A role for TARC/CCL17, a CC chemokine, in systemic lupus erythematosus. Okamoto, H., Koizumi, K., Yamanaka, H., Saito, T., Kamatani, N. J. Rheumatol. (2003) [Pubmed]
  34. T lymphocyte chemotactic chemokines in acute myelogenous leukemia (AML): local release by native human AML blasts and systemic levels of CXCL10 (IP-10), CCL5 (RANTES) and CCL17 (TARC). Olsnes, A.M., Motorin, D., Ryningen, A., Zaritskey, A.Y., Bruserud, O. Cancer Immunol. Immunother. (2006) [Pubmed]
  35. Effect of an antiallergic drug (Olopatadine hydrochloride) on TARC/CCL17 and MDC/CCL22 production by PBMCs from patients with atopic dermatitis. Furukawa, H., Takahashi, M., Nakamura, K., Kaneko, F. J. Dermatol. Sci. (2004) [Pubmed]
  36. Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. Yoshie, O., Fujisawa, R., Nakayama, T., Harasawa, H., Tago, H., Izawa, D., Hieshima, K., Tatsumi, Y., Matsushima, K., Hasegawa, H., Kanamaru, A., Kamihira, S., Yamada, Y. Blood (2002) [Pubmed]
  37. Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer. Nakanishi, T., Imaizumi, K., Hasegawa, Y., Kawabe, T., Hashimoto, N., Okamoto, M., Shimokata, K. Cancer Immunol. Immunother. (2006) [Pubmed]
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