The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sprue, Tropical

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sprue, Tropical


High impact information on Sprue, Tropical

  • In 27 Puerto Rican patients with tropical sprue proven by intestinal biopsy and clinical response to folic acid, HLA type was determined with a microcytotoxicity assay [5].
  • Absorption of water and sodium and activity of adenosine triphosphatases in the rectal mucosa in tropical sprue [6].
  • PP response to the meal was normal in 10 patients with active coeliac disease and 12 patients with acute tropical sprue with steatorrhoea [7].
  • In subjects with vitamin B12 malabsorption due to tropical sprue, the results were identical with the control subjects [8].
  • The degree of essential fatty acid depletion observed is unlikely to be the cause of the mucosal accumulation of triglyceride in tropical sprue [9].

Chemical compound and disease context of Sprue, Tropical

  • Patients with tropical sprue had decreased levels of plasma linoleic acid, raised monoenoic fatty acids and the appearance of 5,8,11-eicosatrienoic acid in the lecithin fraction [9].
  • If these and other gastrointestinal insults, such as tropical sprue, small bowel overgrowth, lactose intolerance, and processes unrelated to travel are excluded by more invasive studies or clinical history, the patient can be reassured that idiopathic chronic diarrhea is usually self-limited [10].
  • When the xylose test is used in tropical countries the effect of systemic infections on the result must be careful evaluated, otherwise tropical malabsorption ('tropical sprue') might be diagnosed erroneously [11].
  • Although hypoalbuminaemia was present in 66% of patients with tropical sprue, in only one case was an increase in jejunal calibre associated with a serum albumin concentration below 27 g/l, the threshold below which jejunal dilatation occurs in hypoalbuminaemia alone [12].
  • The presence of a higher percentage of the dose in the plasma as HCC-3H after the intravenous and oral administrations in the tropical sprue subjects when compared to controls indicates that the diseased state does not alter vitamin D3 metabolism [13].

Anatomical context of Sprue, Tropical

  • Previous studies indicated that many patients with tropical sprue in southern India have triglyceride accumulation within the cells of the intestinal mucosa [9].
  • Although pancreatic hyposecretion has been reported in patient with tropical sprue when indirect stimulation with Lundh meal was applied to pancreas, yet on direct stimulation with secretin, we found pancreatic functions to be normal [14].

Gene context of Sprue, Tropical

  • Autoantibodies to duodenal gastric-inhibitory-peptide (GIP) cells and to secretin (S) cells in patients with coeliac disease, tropical sprue and maturity-onset diabetes [15].
  • Of twelve tropical sprue sera, four reacted with the same two cells [15].
  • Other key issues raised by the case include the vanishing incidence of tropical sprue, an entity to which most clinicians would have mistakenly attributed this malabsorptive syndrome arising in a traveler, and the under-recognition of the protean manifestations of celiac sprue, to which we would add persistent travelers' diarrhea [16].

Analytical, diagnostic and therapeutic context of Sprue, Tropical


  1. Bacterial colonisation of jejunal mucosa in acute tropical sprue. Tomkins, A.M., Drasar, B.S., James, W.P. Lancet (1975) [Pubmed]
  2. Peptide YY abnormalities in gastrointestinal diseases. Adrian, T.E., Savage, A.P., Bacarese-Hamilton, A.J., Wolfe, K., Besterman, H.S., Bloom, S.R. Gastroenterology (1986) [Pubmed]
  3. Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Kakar, S., Nehra, V., Murray, J.A., Dayharsh, G.A., Burgart, L.J. Am. J. Gastroenterol. (2003) [Pubmed]
  4. Intestinal involvement is not sufficient to explain hypertransaminasemia in celiac disease? Peláez-Luna, M., Schmulson, M., Robles-Díaz, G. Med. Hypotheses (2005) [Pubmed]
  5. HLA and tropical sprue. Menendez-Corrada, R., Nettleship, E., Santiago-Delpin, E.A. Lancet (1986) [Pubmed]
  6. Absorption of water and sodium and activity of adenosine triphosphatases in the rectal mucosa in tropical sprue. Ramakrishna, B.S., Mathan, V.I. Gut (1988) [Pubmed]
  7. Impaired pancreatic polypeptide release in chronic pancreatitis with steatorrhoea. Adrian, T.E., Besterman, H.S., Mallinson, C.N., Garalotis, C., Bloom, S.R. Gut (1979) [Pubmed]
  8. Vitamin B12 absorption--a study of intraluminal events in control subjects and patients with tropical sprue. Kapadia, C.R., Bhat, P., Jacob, E., Baker, S.J. Gut (1975) [Pubmed]
  9. Plasma lipids in tropical sprue. Tiruppathi, C., Hill, P.G., Mathan, V.I. Am. J. Clin. Nutr. (1981) [Pubmed]
  10. Persistent diarrhea in the returned traveler. Thielman, N.M., Guerrant, R.L. Infect. Dis. Clin. North Am. (1998) [Pubmed]
  11. Influence of systemic infections on xylose absorption. Cook, G.C. Acta Trop. (1981) [Pubmed]
  12. The relationship between hypoalbuminaemia and the radiological appearances of the jejunum in tropical sprue. McLean, A.M., Farthing, M.J., Kurian, G., Mathan, V.I. The British journal of radiology. (1982) [Pubmed]
  13. The kinetics of D3-3H metabolism in tropical sprue. Haddock, L., Vázquez, M.C., Rivera, R., Corcino, J. Puerto Rico health sciences journal. (1985) [Pubmed]
  14. Pancreatic function tests in tropical sprue is pancreas involved? Sharma, S.K., Dilawari, J.B., Anand, B.S. Gastroenterol. Jpn. (1982) [Pubmed]
  15. Autoantibodies to duodenal gastric-inhibitory-peptide (GIP) cells and to secretin (S) cells in patients with coeliac disease, tropical sprue and maturity-onset diabetes. Mirakian, R., Bottazzo, G.F., Doniach, D. Clin. Exp. Immunol. (1980) [Pubmed]
  16. Persistent diarrhea in the returning traveler: think beyond persistent infection. Landzberg, B.R., Connor, B.A. Scand. J. Gastroenterol. (2005) [Pubmed]
  17. Pteroylglutamic acid malabsorption in tropical sprue. Corcino, J.J., Coll, G., Klipstein, F.A. Blood (1975) [Pubmed]
  18. Assessment of vitamin B12 absorption in tropical sprue utilizing a whole body counter. Corcino, J.J., Dietrich, R., Lanaro, A.E. Boletín de la Asociación Médica de Puerto Rico. (1976) [Pubmed]
WikiGenes - Universities