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Disease relevance of Dominica

  • d-Limonene was investigated for contact and fumigant toxicity, ovicidal effects, oviposition-deterrent, development inhibition, and feeding-deterrent activities against three stored-product beetles (Coleoptera): lesser grain borer, Rhyzopertha dominica (F.); rice weevil, Sitophilus oryzae (L.); and red flour beetle, Tribolium castaneum (Herbst) [1].

High impact information on Dominica

  • [structure: see text] Liphagal (1), a selective inhibitor of PI3K alpha, has been isolated from the marine sponge Aka coralliphaga collected in Dominica [2].
  • Methyl salicylate vapor also had a dose-dependant fumigant effect against S. zeamais, Rhyzopertha dominica, and Prostephanus truncates, with a LD100 achieved with a 60microl dose in a 1-l container against all three insect species after 24 hr of exposure [3].
  • Evolutionary distance analysis suggests that cytochrome c oxidase subunit Va from R. dominica is most similar to the corresponding subunit from the malaria mosquito [4].
  • A cDNA encoding subunit Va of cytochrome c oxidase (EC was cloned and characterized from a lesser grain borer (Rhyzopertha dominica) cDNA library [4].
  • Methoprene was highly effective against R. dominica, but less active on S. oryzae [5].

Associations of Dominica with chemical compounds

  • BApNAase activity in R. dominica midgut was significantly reduced by serine proteinase inhibitors and specific inhibitors of trypsin, whereas BApNAase activity was not sensitive to specific inhibitors of chymotrypsin or aspartic proteinases [6].
  • RH-5849 could achieve almost complete control of F(1) adults of T. castaneum and R. dominica at 10 ppm, but was less potent on S. oryzae [5].
  • Pyriproxyfen was the most effective compound among the four IGRs; a concentration of 0.1 ppm could completely inhibit the F(1) adult occurrence of both S- and R-strains of T. castaneum and its LC(90)s for controlling R. dominica and S. oryzae were 0.1 and 1.2 ppm, respectively [5].
  • The insecticidal activity of juvenile hormone agonists methoprene and pyriproxyfen, and the ecdysone agonists RH-5849 and tebufenozide was evaluated against susceptible and actellic-resistant strains of Tribolium castaneum and susceptible strains of Rhyzopertha dominica and Sitophilus oryzae [5].
  • A TPCK-sensitive caseinolytic protein (P6) with an estimated molecular mass of 24 kDa is present in midgut extracts of R. dominica and can be resolved by electrophoresis on 4-16% polyacrylamide gels [7].

Gene context of Dominica


Analytical, diagnostic and therapeutic context of Dominica

  • Laboratory bioassays were carried out in order to evaluate the effectiveness of two diatomaceous earth (DE) formulations, Insecto and SilicoSec, against adults of Rhyzopertha dominica (F) in eight different grain commodities [9].
  • Liquid chromatography is used to measure the uric acid content of wheat internally infested by various growth stages of granary weevil (Sitophilus granarius), rice weevil (Sitophilus oryzae), and lesser grain borer (Ryzopertha dominica) [10].


  1. Effect of d-limonene on three stored-product beetles. Tripathi, A.K., Prajapati, V., Khanuja, S.P., Kumar, S. J. Econ. Entomol. (2003) [Pubmed]
  2. Liphagal, a Selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga: structure elucidation and biomimetic synthesis. Marion, F., Williams, D.E., Patrick, B.O., Hollander, I., Mallon, R., Kim, S.C., Roll, D.M., Feldberg, L., Van Soest, R., Andersen, R.J. Org. Lett. (2006) [Pubmed]
  3. Effect of volatile constituents from Securidaca longepedunculata on insect pests of stored grain. Jayasekara, T.K., Stevenson, P.C., Hall, D.R., Belmain, S.R. J. Chem. Ecol. (2005) [Pubmed]
  4. Molecular cloning and characterization of a cDNA encoding cytochrome c oxidase subunit Va from the lesser grain borer, Rhyzopertha dominica (F.) (Coleoptera: Bostrichidae). Ayala, J., Dowdy, A.K., Beeman, R.W., Zhu, K.Y. Arch. Insect Biochem. Physiol. (2003) [Pubmed]
  5. Biological activity of two juvenoids and two ecdysteroids against three stored product insects. Kostyukovsky, M., Chen, B., Atsmi, S., Shaaya, E. Insect Biochem. Mol. Biol. (2000) [Pubmed]
  6. Characterization of midgut trypsin-like enzymes and three trypsinogen cDNAs from the lesser grain borer, Rhyzopertha dominica (Coleoptera: Bostrichidae). Zhu, Y.C., Baker, J.E. Insect Biochem. Mol. Biol. (1999) [Pubmed]
  7. Molecular cloning and characterization of a midgut chymotrypsin-like enzyme from the lesser grain borer, Rhyzopertha dominica. Zhu, Y.C., Baker, J.E. Arch. Insect Biochem. Physiol. (2000) [Pubmed]
  8. Characterization of acetylcholinesterase purified from the lesser grain borer, Rhyzopertha dominica (Coleoptera: Bostrichidae). Guedes, R.N., Zhu, K.Y., Kambhampati, S., Dover, B.A. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1998) [Pubmed]
  9. Influence of grain type on the insecticidal efficacy of two diatomaceous earth formulations against Rhyzopertha dominica (F) (Coleoptera: Bostrychidae). Kavallieratos, N.G., Athanassiou, C.G., Pashalidou, F.G., Andris, N.S., Tomanović, Z. Pest Manag. Sci. (2005) [Pubmed]
  10. Stored wheat insect infestation related to uric acid as determined by liquid chromatography. Wehling, R.L., Wetzel, D.L., Pedersen, J.R. Journal - Association of Official Analytical Chemists. (1984) [Pubmed]
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