Chemical Compound Review:
Glidsafe (4R)-1-methyl-4-prop-1-en-2- yl-cyclohexene
Synonyms:
Refchole, Carvene, Citrene, Glidesafe, Kautschiin, ...
Chow,
Salazar,
Hakim,
Carmichael,
Debruyne,
Bigot-Lasserre,
Yano,
Tatsuta,
Iishi,
Baba,
Sakai,
Uedo,
Vigushin,
Poon,
Boddy,
English,
Halbert,
Pagonis,
Jarman,
Coombes,
Kaji,
Tatsuta,
Iishi,
Baba,
Inoue,
Kasugai,
Ozaki,
Takahara,
Kawahara,
Wada-Katsumata,
Seno,
Amakawa,
Yamaoka,
Nakamura,
Hakim,
Harris,
Ritenbaugh,
Duetz,
Fjällman,
Ren,
Jourdat,
Witholt,
Parija,
Das,
- Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. Wattenberg, L.W., Sparnins, V.L., Barany, G. Cancer Res. (1989)
- Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors. Jirtle, R.L., Haag, J.D., Ariazi, E.A., Gould, M.N. Cancer Res. (1993)
- Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. Elegbede, J.A., Elson, C.E., Qureshi, A., Tanner, M.A., Gould, M.N. Carcinogenesis (1984)
- Anti-carcinogenic activity of d-limonene during the initiation and promotion/progression stages of DMBA-induced rat mammary carcinogenesis. Elson, C.E., Maltzman, T.H., Boston, J.L., Tanner, M.A., Gould, M.N. Carcinogenesis (1988)
- Attenuation by d-limonene of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Yano, H., Tatsuta, M., Iishi, H., Baba, M., Sakai, N., Uedo, N. Int. J. Cancer (1999)
- Chemoprevention of spontaneous tumorigenesis in p53-knockout mice. Hursting, S.D., Perkins, S.N., Haines, D.C., Ward, J.M., Phang, J.M. Cancer Res. (1995)
- The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. Dietrich, D.R., Swenberg, J.A. Cancer Res. (1991)
- Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. Crowell, P.L., Chang, R.R., Ren, Z.B., Elson, C.E., Gould, M.N. J. Biol. Chem. (1991)
- Risk assessment of d-limonene: an example of male rat-specific renal tumorigens. Hard, G.C., Whysner, J. Crit. Rev. Toxicol. (1994)
- The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil. Maltzman, T.H., Hurt, L.M., Elson, C.E., Tanner, M.A., Gould, M.N. Carcinogenesis (1989)
- Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2). Kawata, S., Nagase, T., Yamasaki, E., Ishiguro, H., Matsuzawa, Y. Br. J. Cancer (1994)
- Biotransformation of D-limonene to (+) trans-carveol by toluene-grown Rhodococcus opacus PWD4 cells. Duetz, W.A., Fjällman, A.H., Ren, S., Jourdat, C., Witholt, B. Appl. Environ. Microbiol. (2001)
- Perception of noxious compounds by contact chemoreceptors of the blowfly, Phormia regina: putative role of an odorant-bindingpProtein. Ozaki, M., Takahara, T., Kawahara, Y., Wada-Katsumata, A., Seno, K., Amakawa, T., Yamaoka, R., Nakamura, T. Chem. Senses (2003)
- Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats. Kanerva, R.L., Ridder, G.M., Lefever, F.R., Alden, C.L. Food Chem. Toxicol. (1987)
- Hydroxylation of specifically deuterated limonene enantiomers by cytochrome p450 limonene-6-hydroxylase reveals the mechanism of multiple product formation. Wüst, M., Croteau, R.B. Biochemistry (2002)
- Pharmacokinetics of perillic acid in humans after a single dose administration of a citrus preparation rich in d-limonene content. Chow, H.H., Salazar, D., Hakim, I.A. Cancer Epidemiol. Biomarkers Prev. (2002)
- Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model. Koyama, Y., Bando, H., Yamashita, F., Takakura, Y., Sezaki, H., Hashida, M. Pharm. Res. (1994)
- Citrus peel use is associated with reduced risk of squamous cell carcinoma of the skin. Hakim, I.A., Harris, R.B., Ritenbaugh, C. Nutrition and cancer. (2000)
- Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association. Kaji, I., Tatsuta, M., Iishi, H., Baba, M., Inoue, A., Kasugai, H. Int. J. Cancer (2001)
- Inhibitory effects of d-limonene on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. Kawamori, T., Tanaka, T., Hirose, Y., Ohnishi, M., Mori, H. Carcinogenesis (1996)
- Metabolism of d-limonene by hepatic microsomes to non-mutagenic epoxides toward Salmonella typhimurium. Watabe, T., Hiratsuka, A., Isobe, M., Ozawa, N. Biochem. Pharmacol. (1980)
- Biochemical basis for mouse resistance to hyaline droplet nephropathy: lack of relevance of the alpha 2u-globulin protein superfamily in this male rat-specific syndrome. Lehman-McKeeman, L.D., Caudill, D. Toxicol. Appl. Pharmacol. (1992)
- Perillic acid inhibits Ras/MAP kinase-driven IL-2 production in human T lymphocytes. Schulz, S., Reinhold, D., Schmidt, H., Ansorge, S., Höllt, V. Biochem. Biophys. Res. Commun. (1997)
- Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes. Schulz, S., Bühling, F., Ansorge, S. Eur. J. Immunol. (1994)
- Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils. Wattenberg, L.W., Coccia, J.B. Carcinogenesis (1991)
- Ciprofibrate represses alpha 2u-globulin expression in liver and inhibits d-limonene nephrotoxicity. Alvares, K., Subbarao, V., Rao, M.S., Reddy, J.K. Carcinogenesis (1996)
- Involvement of YY1 and its correlation with c-myc in NDEA induced hepatocarcinogenesis, its prevention by d-limonene. Parija, T., Das, B.R. Mol. Biol. Rep. (2003)
- d-limonene chemoprevention of hepatocarcinogenesis in AKR mice: inhibition of c-jun and c-myc. Giri, R.K., Parija, T., Das, B.R. Oncol. Rep. (1999)
- The introduction of activated oncogenes to mammary cells in vivo using retroviral vectors: a new model for the chemoprevention of premalignant and malignant lesions of the breast. Gould, M.N. J. Cell. Biochem. Suppl. (1993)
- Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation. Crowell, P.L., Ren, Z., Lin, S., Vedejs, E., Gould, M.N. Biochem. Pharmacol. (1994)
- Design of a gas chromatograph with parallel radioactivity and mass spectrometric detection. Application to the identification of the major metabolite of d-limonene associated with alpha 2u-globulin. Rodriguez, P.A., Takigiku, R., Lehman-McKeeman, L.D., Fey, M.L., Eddy, C.L., Caudill, D. J. Chromatogr. (1991)
- Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene. Crowell, P.L., Kennan, W.S., Haag, J.D., Ahmad, S., Vedejs, E., Gould, M.N. Carcinogenesis (1992)
- The p53 heterozygous knockout mouse as a model for chemical carcinogenesis in vascular tissue. Carmichael, N.G., Debruyne, E.L., Bigot-Lasserre, D. Environ. Health Perspect. (2000)
- d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and alpha 2u-globulin. Lehman-McKeeman, L.D., Rodriguez, P.A., Takigiku, R., Caudill, D., Fey, M.L. Toxicol. Appl. Pharmacol. (1989)
- Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Vigushin, D.M., Poon, G.K., Boddy, A., English, J., Halbert, G.W., Pagonis, C., Jarman, M., Coombes, R.C. Cancer Chemother. Pharmacol. (1998)