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Gene Review

Ftlg1  -  fetal gene 1

Mus musculus

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Disease relevance of Ftlg1


Psychiatry related information on Ftlg1


High impact information on Ftlg1


Biological context of Ftlg1


Anatomical context of Ftlg1


Associations of Ftlg1 with chemical compounds

  • METHODS: Fetal porcine islet-like cell clusters (ICCs) were transplanted into normoglycemic rats that were either left untreated or treated with FTY720 only, with FTY720 plus cyclosporine A (CsA) or with CsA only [21].
  • Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome [22].
  • OBJECTIVE: On the basis of the recent Maternal Fetal Medicine Unit Networks clinical trial, the American College of Obstetricians and Gynecologists supports the administration of 17-alpha hydroxyprogesterone caproate to high-risk patients [23].

Regulatory relationships of Ftlg1

  • METHODS: Fetal constraint was induced through uterine cerclage of six pregnant C57Bl/6 mice on the eighteenth day of gestation [24].

Other interactions of Ftlg1

  • CONCLUSIONS: Fetal (E17 and E19) fibroblasts have lower CTGF expression compared with adult fibroblasts [25].
  • METHODS: Fetal and postnatal corneal histopathology, adult corneal thickness, and the distribution of K12-immunostained cells were compared in wild-type and Pax6(+/-) mice [26].
  • Diabetes-Induced Fetal Growth Retardation is Associated with Suppression of NF-kappaB Activity in Embryos [27].

Analytical, diagnostic and therapeutic context of Ftlg1

  • Artificial Perfusion of the Fetal Circulation of the In situ Mouse Placenta: Methodology and Validation [28].
  • RESULTS: Fetal defects caused by all four chemicals studied were reduced by maternal immunostimulation, sometimes dramatically [29].
  • These results importantly contribute to the development of an animal model of Fetal Alcohol Syndrome in which both the behavioral and morphological consequences of prenatal alcohol exposure may be assessed in the same species [30].


  1. The ontogeny of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. Brown, R.W., Diaz, R., Robson, A.C., Kotelevtsev, Y.V., Mullins, J.J., Kaufman, M.H., Seckl, J.R. Endocrinology (1996) [Pubmed]
  2. Effects of methylmercury on the brain of infant rats reared artificially. Naruse, I., Arakawa, H., Fukui, Y. Tokushima J. Exp. Med. (1993) [Pubmed]
  3. Alcohol as a teratogen: a decade of research in review. Randall, C.L. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. (1987) [Pubmed]
  4. Reduced birth defects caused by maternal immune stimulation in methylnitrosourea-exposed mice: association with placental improvement. Prater, M.R., Zimmerman, K.L., Ward, D.L., Holladay, S.D. Birth defects research. Part A, Clinical and molecular teratology. (2004) [Pubmed]
  5. Long-term alcohol exposure prior to conception results in lower fetal body weights. Livy, D.J., Maier, S.E., West, J.R. Birth Defects Res. B Dev. Reprod. Toxicol. (2004) [Pubmed]
  6. Immunology. Fetal fascination. Heemels, M.T. Nature (1998) [Pubmed]
  7. Identification of expandable human hepatic progenitors which differentiate into mature hepatic cells in vivo. Nowak, G., Ericzon, B.G., Nava, S., Jaksch, M., Westgren, M., Sumitran-Holgersson, S. Gut (2005) [Pubmed]
  8. Specific acceptance of fetal bowel allograft in mice after combined treatment with anti-intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 antibodies. Kato, Y., Yamataka, A., Yagita, H., Okumura, K., Fujiwara, T., Miyano, T. Ann. Surg. (1996) [Pubmed]
  9. Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair. Adzick, N.S., Lorenz, H.P. Ann. Surg. (1994) [Pubmed]
  10. Estrogen Related Receptor-{alpha} Enhances Surfactant Protein-A Gene Expression in Fetal Lung Type II Cells. Liu, D., Hinshelwood, M.M., Gigu??re, V., Mendelson, C.R. Endocrinology (2006) [Pubmed]
  11. A quantitative bioassay for erythropoietin using mouse fetal liver cells. Dunn, C.D., Jarvis, J.H., Greenman, J.M. Exp. Hematol. (1975) [Pubmed]
  12. Cardiac mitochondrial abnormalities in a mouse model of the fetal alcohol syndrome. Nyquist-Battie, C., Freter, M. Alcohol. Clin. Exp. Res. (1988) [Pubmed]
  13. Microchimerism and tolerance after in utero bone marrow transplantation in mice. Kim, H.B., Shaaban, A.F., Yang, E.Y., Liechty, K.W., Flake, A.W. J. Surg. Res. (1998) [Pubmed]
  14. Phenytoin-induced alterations in craniofacial gene expression. Gelineau-van Waes, J., Bennett, G.D., Finnell, R.H. Teratology (1999) [Pubmed]
  15. Amelioration of hyperglycemia in streptozotocin-induced diabetic mice with fetal pancreatic allografts: prevention of rejection by donor specific transfusion in conjunction with CTLA4Ig. Hirakawa, E., Yasunami, Y., Nakano, M., Shiiba, M., Takehara, M., Uede, T., Todo, S., Ono, J., Ikeda, S. Pancreas (2004) [Pubmed]
  16. RNA binding protein Musashi1 is expressed in sertoli cells in the rat testis from fetal life to adulthood. Saunders, P.T., Maguire, S.M., Macpherson, S., Fenelon, M.C., Sakakibara, S., Okano, H. Biol. Reprod. (2002) [Pubmed]
  17. Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro. Van Bezooijen, R.L., Van Der Wee-Pals, L., Papapoulos, S.E., Löwik, C.W. Ann. Rheum. Dis. (2002) [Pubmed]
  18. Reorganized small intestine from fetal mouse as an in vitro wound healing model. Yonekawa, H., Murata, E., Akita, M., Satomi, A. J. Gastroenterol. (2003) [Pubmed]
  19. Pathogenesis of ethanol-induced hydronephrosis and hydroureter as demonstrated following in vivo exposure of mouse embryos. Gage, J.C., Sulik, K.K. Teratology (1991) [Pubmed]
  20. Assays of thymic selection. Fetal thymus organ culture and in vitro thymocyte dulling assay. Hogquist, K.A. Methods Mol. Biol. (2001) [Pubmed]
  21. Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats. Maeda, A., Goto, M., Zhang, J., Bennet, W., Groth, C.G., Korsgren, O., Wennberg, L. Transplantation (2003) [Pubmed]
  22. Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. Green, M.L., Singh, A.V., Zhang, Y., Nemeth, K.A., Sulik, K.K., Knudsen, T.B. Dev. Dyn. (2007) [Pubmed]
  23. The use of progestational agents for preterm birth: lessons from a mouse model. Elovitz, M.A., Mrinalini, C. Am. J. Obstet. Gynecol. (2006) [Pubmed]
  24. Intrauterine fetal constraint induces chondrocyte apoptosis and premature ossification of the cranial base. Smartt, J.M., Karmacharya, J., Gannon, F.H., Teixeira, C., Mansfield, K., Hunenko, O., Shapiro, I.M., Kirschner, R.E. Plast. Reconstr. Surg. (2005) [Pubmed]
  25. Fetal and adult fibroblasts have similar TGF-beta-mediated, Smad-dependent signaling pathways. Colwell, A.S., Krummel, T.M., Longaker, M.T., Lorenz, H.P. Plast. Reconstr. Surg. (2006) [Pubmed]
  26. Corneal abnormalities in Pax6+/- small eye mice mimic human aniridia-related keratopathy. Ramaesh, T., Collinson, J.M., Ramaesh, K., Kaufman, M.H., West, J.D., Dhillon, B. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  27. Diabetes-Induced Fetal Growth Retardation is Associated with Suppression of NF-kappaB Activity in Embryos. Mammon, K., Keshet, R., Savion, S., Pekar, O., Zaslavsky, Z., Fein, A., Toder, V., Torchinsky, A. The review of diabetic studies : RDS (2005) [Pubmed]
  28. Artificial Perfusion of the Fetal Circulation of the In situ Mouse Placenta: Methodology and Validation. Bond, H., Baker, B., Boyd, R.D., Cowley, E., Glazier, J.D., Jones, C.J., Sibley, C.P., Ward, B.S., Husain, S.M. Placenta (2006) [Pubmed]
  29. Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations. Holladay, S.D., Sharova, L., Smith, B.J., Gogal, R.M., Ward, D.L., Blaylock, B.L. Teratology (2000) [Pubmed]
  30. Effect of prenatal ethanol exposure on activity and shuttle avoidance behavior in adult C57 mice. Randall, C.L., Becker, H.C., Middaugh, L.D. Alcohol and drug research. (1985) [Pubmed]
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