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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hypesthesia

  • We have treated nine patients suffering from severe occipital pain with associated C2 hypesthesia, unilateral retro-orbital pain, and occipital or C2 tubercle trigger points by intradurally sectioning the C1-C4 dorsal rootlets (C4 if shoulder pain existed) [1].
  • Quantitative sensory testing revealed that pain induced by intracutaneous capsaicin injection elicited secondary hyperalgesia coexisting with secondary tactile hypoesthesia [2].
  • The reduced sensation of dyspnea during exercise by inhaled oxitropium bromide in severe COPD patients [3].
  • Temporal arteritis was suspected and prednisolone started with prompt resolution of the headache, chin hypoesthesia, ESR, and CRP [4].
  • These included 16 patients with hypesthesia of the infraorbital nerve, 5 patients with sinusitis, 3 patients who had incomplete decompression, 2 patients with oral antral fistulae, and 1 patient who had CSF rhinorrhea [5].

Psychiatry related information on Hypesthesia


High impact information on Hypesthesia

  • Recent clinical trials indicated that an inhibitor of aldose reductase (AR), the rate-limiting enzyme in the polyol pathway, significantly improved hypesthesia in diabetic patients [7].
  • The most common adverse events related to amprenavir were headache, nausea, and hypesthesia [8].
  • This unilateral absence of pain was not related to the hypoesthesia that was caused by the operation, and it was associated with a decrease in vascular responses (histamine-induced facial flushing and increase in temperature) on the side operated on [9].
  • Neurological examination disclosed chin hypoesthesia while investigations showed a normocytic anemia, ESR of 100, and CRP of 72 [4].
  • CLINICAL PRESENTATION: A young man presented with subacute left facial hypesthesia and chronic asymmetrical sensorineural hearing loss [10].

Chemical compound and disease context of Hypesthesia

  • This finding suggests that, contrary to the general belief, persistent hypesthesia after glycerol rhizolysis is a negative indicator of long-term success [11].
  • We present a case of glove and stocking hypoesthesia, weakness of the flexor muscle of the right great toe, palpable thickening of the right popliteal nerve, and hypoesthetic but normal-appearing areas on the back, which developed in a Trinidadian immigrant who lived in Canada for 16 years [12].
  • Fifteen minutes after the injection of 10 ml mepivacaine, the dermatome levels of hypesthesia to cold and pinprick were determined by an individual blinded to the saline volume [13].
  • The effect of corneal hypesthesia on the duration of proparacaine anesthetic eyedrops [14].
  • PURPOSE: To determine whether substance P concentrations in tears reflect corneal hypesthesia [15].

Biological context of Hypesthesia

  • Subjects were also subgrouped into three groups (normal, insulin resistance, and diabetes) according to glucose metabolic status, and those with hypoesthesia at each frequency were excluded in the analyses [16].

Anatomical context of Hypesthesia


Gene context of Hypesthesia


Analytical, diagnostic and therapeutic context of Hypesthesia


  1. Occipital neuralgia treated by intradural dorsal nerve root sectioning. Horowitz, M.B., Yonas, H. Cephalalgia : an international journal of headache. (1993) [Pubmed]
  2. Secondary tactile hypoesthesia: a novel type of pain-induced somatosensory plasticity in human subjects. Magerl, W., Treede, R.D. Neurosci. Lett. (2004) [Pubmed]
  3. The reduced sensation of dyspnea during exercise by inhaled oxitropium bromide in severe COPD patients. Teramoto, S., Fukuchi, Y. Chest (1995) [Pubmed]
  4. The numb chin syndrome as an early manifestation of giant-cell (temporal) arteritis: a case report. Abilleira, S., Bowler, J.V. Headache. (2005) [Pubmed]
  5. Long-term follow-up and recent observations on 305 cases of orbital decompression for dysthyroid orbitopathy. Warren, J.D., Spector, J.G., Burde, R. Laryngoscope (1989) [Pubmed]
  6. Compulsive water drinking treated with high dose propranolol. Shevitz, S.A., Jameison, R.C., Petrie, W.M., Crook, J.E. J. Nerv. Ment. Dis. (1980) [Pubmed]
  7. Neurotrophin-3-induced production of nerve growth factor is suppressed in Schwann cells exposed to high glucose: involvement of the polyol pathway. Suzuki, T., Sekido, H., Kato, N., Nakayama, Y., Yabe-Nishimura, C. J. Neurochem. (2004) [Pubmed]
  8. Safety and pharmacokinetics of amprenavir (141W94), a human immunodeficiency virus (HIV) type 1 protease inhibitor, following oral administration of single doses to HIV-infected adults. Sadler, B.M., Hanson, C.D., Chittick, G.E., Symonds, W.T., Roskell, N.S. Antimicrob. Agents Chemother. (1999) [Pubmed]
  9. Unilateral reduction of head pain and facial vasodilatation after gasserian ganglion lesion. De Marinis, M., Fraioli, B., Esposito, V., Gagliardi, F.M., Agnoli, A. Arch. Neurol. (1993) [Pubmed]
  10. Cavernous malformation presenting as an extra-axial cerebellopontine angle mass: case report. Kim, M., Rowed, D.W., Cheung, G., Ang, L.C. Neurosurgery (1997) [Pubmed]
  11. Relation of hypesthesia to the outcome of glycerol rhizolysis for trigeminal neuralgia. Sahni, K.S., Pieper, D.R., Anderson, R., Baldwin, N.G. J. Neurosurg. (1990) [Pubmed]
  12. Leprotic involvement of peripheral nerves in the absence of skin lesions. Case report and literature review. Jenkins, D., Papp, K., Jakubovic, H.R., Shiffman, N. J. Am. Acad. Dermatol. (1990) [Pubmed]
  13. Saline volume and local anesthetic concentration modify the spread of epidural anesthesia. Okutomi, T., Minakawa, M., Hoka, S. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1999) [Pubmed]
  14. The effect of corneal hypesthesia on the duration of proparacaine anesthetic eyedrops. Weiss, J.S., Goren, M.B. Am. J. Ophthalmol. (1991) [Pubmed]
  15. Decreased substance P concentrations in tears from patients with corneal hypesthesia. Yamada, M., Ogata, M., Kawai, M., Mashima, Y. Am. J. Ophthalmol. (2000) [Pubmed]
  16. Prevalence of hyperesthesia detected by current perception threshold test in subjects with glucose metabolic impairments in a community. Takekuma, K., Ando, F., Niino, N., Shimokata, H. Intern. Med. (2002) [Pubmed]
  17. Evoked trigeminal nerve potential in chronic trichloroethylene intoxication. Barret, L., Arsac, P., Vincent, M., Faure, J., Garrel, S., Reymond, F. J. Toxicol. Clin. Toxicol. (1982) [Pubmed]
  18. Extranodal Rosai-Dorfman disease with multiple spinal lesions: a rare presentation. Bhandari, A., Patel, P.R., Patel, M.P. Surgical neurology. (2006) [Pubmed]
  19. Chordoma of the thoracic spine--case report. Topsakal, C., Bulut, S., Erol, F.S., Ozercan, I., Yildirim, H. Neurol. Med. Chir. (Tokyo) (2002) [Pubmed]
  20. Performance of a high-repetition, high-force task induces carpal tunnel syndrome in rats. Clark, B.D., Al-Shatti, T.A., Barr, A.E., Amin, M., Barbe, M.F. The Journal of orthopaedic and sports physical therapy. (2004) [Pubmed]
  21. Quantitative sensory testing in patients with incomplete spinal cord injury. Krassioukov, A., Wolfe, D.L., Hsieh, J.T., Hayes, K.C., Durham, C.E. Archives of physical medicine and rehabilitation. (1999) [Pubmed]
  22. Peripheral neuropathy associated with weekly oral 5-fluorouracil, leucovorin and eniluracil. Saif, M.W., Wilson, R.H., Harold, N., Keith, B., Dougherty, D.S., Grem, J.L. Anticancer Drugs (2001) [Pubmed]
  23. A clinical comparison of trigeminal neuralgic pain in patients with and without underlying multiple sclerosis. De Simone, R., Marano, E., Brescia Morra, V., Ranieri, A., Ripa, P., Esposito, M., Vacca, G., Bonavita, V. Neurol. Sci. (2005) [Pubmed]
  24. Orbital decompression for Graves' disease: exposure through a modified blepharoplasty incision. Antoszyk, J.H., Tucker, N., Codère, F. Ophthalmic surgery. (1992) [Pubmed]
  25. Multifocal primary CNS T cell lymphoma of the spinal cord. Lee, D.K., Chung, C.K., Kim, H.J., Kim, K., Choe, G., Moon, C.W., Kim, D.Y. Clin. Neuropathol. (2002) [Pubmed]
  26. Staged TRAM breast reconstruction: combining the advantages of tissue expansion with surgical delay. Hudson, D.A., van Zyl, J.E., Duminy, F.J., Silfen, R. Aesthetic plastic surgery. (2000) [Pubmed]
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