The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rosaceae

  • BACKGROUND: Lipid transfer protein (LTP), the major allergen in Rosaceae in geographic areas where the prevalence of birch pollen allergy is low, is a widely cross-reacting pan-allergen, but the pattern of cross-reactivity to plant-derived foods botanically unrelated to Rosaceae shows much variability [1].
  • We have investigated the effects of three types of procyanidin isolated from apple (Rosaceae Malus pumila) on DNA of human stomach cancer KATO III cells [2].
  • The kosins are phloroglucinol derivatives isolated from female flowers of Hagenia abyssinica (Rosaceae) and were tested for possible cytotoxic activity in vitro and in vivo against a panel of three transplantable murine adenocarcinomas of the colon of varying growth characteristics and morphology (MAC system) [3].

High impact information on Rosaceae

  • The most frequent allergens were 14% Rosaceae, 9% vegetables, 8% milk, 8% crustaceans, 5% fruit cross-reacting with latex, 4% egg, 3% tree nuts, and 1% peanut [4].
  • The greatest sequence similarity was with aldose-6-phosphate reductase (EC, a key enzyme in sorbitol synthesis in Rosaceae [5].
  • The fruit allergens involved showed cross-reactivity among Rosaceae species but were not related to profilin or Bet v 1 [6].
  • Biphenyls and dibenzofurans are the phytoalexins of the Maloideae, a subfamily of the economically important Rosaceae [7].
  • Both isolated LTPs bound specific IgE of sera from Rosaceae fruits allergic patients [8].

Biological context of Rosaceae

  • The finding that the DefH9-iaaM auxin-synthesizing gene increases the number of inflorescences per plant and the number of flowers per inflorescence indicates that auxin plays a role in plant fecundity in these three perennial Rosaceae species [9].

Associations of Rosaceae with chemical compounds

  • All the dicots tested contained the enzymatic machinery permitting MeG synthesis from methanol and glucose, but the plants accumulating this compound at concentrations higher than 1 micromol g(-1) wet wt were mainly members of the Rosaceae family belonging to the Rosoideae subfamily [10].
  • In order to isolate TF inhibitors from the fruits of Chaenomeles sinensis, an activity-guided purification was carried out to yield four triterpenoid compounds [11].
  • In the Rosaceae family, which includes Prunus, gametophytic self-incompatibility (GSI) is controlled by a single multiallelic locus (S-locus), and the S-locus product expressed in the pistils is a glycoprotein with ribonuclease activity (S-RNase) [12].
  • Isolation, characterization, and systematic significance of 2-pyrone-4,6-dicarboxylic acid in Rosaceae [13].
  • For the first time, a cytosolic carotenoid cleavage enzyme isolated from quince (Cydonia oblonga) fruit is described [14].

Gene context of Rosaceae

  • RT-PCR was used to obtain the first estimates from natural populations of allelic diversity at the RNase-based gametophytic self-incompatibility locus in the Rosaceae [15].
  • Three features significantly distinguished pollinic from nonpollinic patients: 1) a more common complaint of symptoms after ingestion of Rosaceae fruits or nuts (10.2%) 2) a family history of atopy (8.8%) 3) a greater occurrence of bronchial asthmatic symptoms (23%) [16].
  • METHODS: Thirty-eight patients with a positive SPT to Rosaceae fruit extracts enriched for LTP were characterized by interview and SPT [17].
  • Absorption and reflectance spectra of maple (Acer platanoides), cotoneaster (Cotoneaster alaunica), dogwood (Cornus alba) and pelargonium (Pelargonium zonale) leaves with a wide range of pigment content and composition were studied in visible and near-infrared spectra in order to reveal specific anthocyanin (Anth) spectral features in leaves [18].
  • Quince (Cydonia oblonga Miller) fruit (pulp, peel, and seed) and Jam: antioxidant activity [19].

Analytical, diagnostic and therapeutic context of Rosaceae

  • From pericarps of Rosa davurica (Rosaceae), a traditional Chinese medicine, eight known tetracyclic triterpene acids, three known flavonoids, ethyl beta-fructopyranoside and methyl 3-O-beta-glucopyranosyl-gallate were isolated [20].
  • A 35% EtOH extract of the fruits of Chaenomeles sinensis, long utilized as a folk medicine for cough, significantly inhibited the pruritogenic agent compound 48/80 (COM)-induced scratching behavior in mice [21].


  1. Relationship between peach lipid transfer protein specific IgE levels and hypersensitivity to non-Rosaceae vegetable foods in patients allergic to lipid transfer protein. Asero, R., Mistrello, G., Roncarolo, D., Amato, S. Ann. Allergy Asthma Immunol. (2004) [Pubmed]
  2. Induction of apoptosis by three types of procyanidin isolated from apple (Rosaceae Malus pumila) in human stomach cancer KATO III cells. Hibasami, H., Shohji, T., Shibuya, I., Higo, K., Kanda, T. Int. J. Mol. Med. (2004) [Pubmed]
  3. Evaluation of the anti-tumour action and acute toxicity of kosins from Hagenia abyssinica. Woldemariam, T.Z., Fell, A.F., Linley, P.A., Bibby, M.C., Phillips, R.M. Journal of pharmaceutical and biomedical analysis. (1992) [Pubmed]
  4. Population study of food allergy in France. Kanny, G., Moneret-Vautrin, D.A., Flabbee, J., Beaudouin, E., Morisset, M., Thevenin, F. J. Allergy Clin. Immunol. (2001) [Pubmed]
  5. Molecular cloning of mannose-6-phosphate reductase and its developmental expression in celery. Everard, J.D., Cantini, C., Grumet, R., Plummer, J., Loescher, W.H. Plant Physiol. (1997) [Pubmed]
  6. Allergy to Rosaceae fruits without related pollinosis. Fernández-Rivas, M., van Ree, R., Cuevas, M. J. Allergy Clin. Immunol. (1997) [Pubmed]
  7. Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia. Liu, B., Beuerle, T., Klundt, T., Beerhues, L. Planta (2004) [Pubmed]
  8. Lipid-transfer proteins as potential plant panallergens: cross-reactivity among proteins of Artemisia pollen, Castanea nut and Rosaceae fruits, with different IgE-binding capacities. Díaz-Perales, A., Lombardero, M., Sánchez-Monge, R., García-Selles, F.J., Pernas, M., Fernández-Rivas, M., Barber, D., Salcedo, G. Clin. Exp. Allergy (2000) [Pubmed]
  9. The defH9-iaaM auxin-synthesizing gene increases plant fecundity and fruit production in strawberry and raspberry. Mezzetti, B., Landi, L., Pandolfini, T., Spena, A. BMC Biotechnol. (2004) [Pubmed]
  10. Methyl-beta-D-glucopyranoside in higher plants: accumulation and intracellular localization in Geum montanum L. leaves and in model systems studied by 13C nuclear magnetic resonance. Aubert, S., Choler, P., Pratt, J., Douzet, R., Gout, E., Bligny, R. J. Exp. Bot. (2004) [Pubmed]
  11. A new in vitro tissue factor inhibitory triterpene from the fruits of Chaenomeles sinensis. Lee, M.H., Han, Y.N. Planta Med. (2003) [Pubmed]
  12. Allelic diversity of S-RNase at the self-incompatibility locus in natural flowering cherry populations (Prunus lannesiana var. speciosa). Kato, S., Mukai, Y. Heredity (2004) [Pubmed]
  13. Isolation, characterization, and systematic significance of 2-pyrone-4,6-dicarboxylic acid in Rosaceae. Wilkes, S., Glasl, H. Phytochemistry (2001) [Pubmed]
  14. Partial purification and kinetic characterization of a carotenoid cleavage enzyme from quince fruit (Cydonia oblonga). Fleischmann, P., Studer, K., Winterhalter, P. J. Agric. Food Chem. (2002) [Pubmed]
  15. S-allele diversity in Sorbus aucuparia and Crataegus monogyna (Rosaceae: Maloideae). Raspé, O., Kohn, J.R. Heredity (2002) [Pubmed]
  16. Prevalence of pollinosis in the Basque Country. Azpiri, A., Gamboa, P.M., Fernández, E., Fernández de Corres, L., Alonso, E., Escobar, A., Jáuregui, I., Audicana, M., Munõz, D., Antépera, I. Allergy (1999) [Pubmed]
  17. Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Asero, R., Mistrello, G., Roncarolo, D., de Vries, S.C., Gautier, M.F., Ciurana, C.L., Verbeek, E., Mohammadi, T., Knul-Brettlova, V., Akkerdaas, J.H., Bulder, I., Aalberse, R.C., van Ree, R. Int. Arch. Allergy Immunol. (2000) [Pubmed]
  18. Optical properties and nondestructive estimation of anthocyanin content in plant leaves. Gitelson, A.A., Merzlyak, M.N., Chivkunova, O.B. Photochem. Photobiol. (2001) [Pubmed]
  19. Quince (Cydonia oblonga Miller) fruit (pulp, peel, and seed) and Jam: antioxidant activity. Silva, B.M., Andrade, P.B., Valentão, P., Ferreres, F., Seabra, R.M., Ferreira, M.A. J. Agric. Food Chem. (2004) [Pubmed]
  20. Chemical constituents of pericarps of Rosa davurica Pall., a traditional Chinese medicine. Kuang, H.X., Kasai, R., Ohtani, K., Liu, Z.S., Yuan, C.S., Tanaka, O. Chem. Pharm. Bull. (1989) [Pubmed]
  21. Antipruritic effects of the fruits of Chaenomeles sinensis. Oku, H., Ueda, Y., Ishiguro, K. Biol. Pharm. Bull. (2003) [Pubmed]
WikiGenes - Universities