Disease relevance of Meliaceae

• The dichloromethane-methanol (1/1) extract of the stem bark of Turraeanthus africanus (Meliaceae) showed remarkable antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus [1].
• The destructive effect of khaya gum used as a binding agent in a paracetamol formulation on Bacillus subtilis spores during tableting has been investigated, in comparison with the effects of two standard binders-polyvinylpyrrolidone and gelatin [2].

High impact information on Meliaceae

• Two diterpenes and acetophenone from Dysoxylum lenticellare [3].
• Flavopiridol is a semi-synthetic flavone analog of the alkaloid, rohitukine, a compound from an Indian tree, Dysoxylum binectariferum [4].
• An ultraviolet spectrophotometric method was validated for total flavonoid quantitation, as rutin equivalents, present in the Trichilia catigua Adr [5].
• The release of paracetamol from khaya gum matrices followed time-independent kinetics (n = 1.042) and release rates were dependent on the concentration of the drug present in the matrix [6].
• The crude methanol extracts of the root barks of Turraea wakefieldii and Turraea floribunda were found to show mosquito larvicidal activity against third-instar larvae of Anopheles gambiae sensu stricto [7].

Anatomical context of Meliaceae

• Two limonoids from Turraea obtusifolia (Meliaceae), prieurianin and rohitukin, antagonise 20-hydroxyecdysone action in a Drosophila cell line [8].

Associations of Meliaceae with chemical compounds

• Khaya gum matrices provided a controlled release of paracetamol for up to 5 h [6].
• New multiflorane-type triterpenoid acids from Sandoricum indicum [9].
• Prieurianoside, a protolimonoid glucoside from the leaves of Trichilia prieuriana [10].
• The limonoid 21,24,25,26,27-pentanor-15,22-oxo-7alpha,23-dihydroxy-apotirucalla(eupha)-1-en-3-one was isolated from the dichloromethane extract of the stem bark of Trichilia estipulata [11].
• The hepatoprotective properties of Trichilia roka may be correlated to polyphenol content of the decoction and its diethyl ether-soluble fraction [12].

Gene context of Meliaceae

• An ethyl acetate leaf extract of Trichilia dregeana showed selective inhibition of COX-2 (81%) [13].
• In this paper, we describe the evaluation of the inhibitory activity on L. tarentolae APRT enzyme of 46 crude extracts of Meliaceae and Rutaceae plants, besides three furoquinolone alkaloids [14].
• DNA polymerase beta inhibitors from Sandoricum koetjape [15].
• In this study, the content and the antioxidant activity of phenolic acids from Trichilia emetica root were evaluated [16].
• The present data are part of a wide explorative investigation on the effects of Trichilia catigua (catuaba), which found that PLA2 activity was totally inhibited by catuaba at a concentration of 120 microg/mL, suggesting that this natural substance may have antiinflammatory properties [17].

Analytical, diagnostic and therapeutic context of Meliaceae

• This study was carried out to investigate the effect of concurrent oral administration of aqueous leaf extract of Azadirachta indica (Meliaceae) on the pharmacokinetic properties of chloroquine sulphate in experimental rabbits [18].

References