The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Humulus

  • Bioassay-guided fractionation of a hexane extract of strobile hops (Humulus lupulus) was undertaken to isolate and characterize the antimycobacterial constituents using the fast-growing mycobacterial species Mycobacterium fortuitum [1].
  • Xanthohumol (XN) is one of the major prenylflavonoids found in hop cones (Humulus lupulus L.). In this study, we investigated the cell growth inhibitory potential of XN on cultured human colon cancer cells [2].

High impact information on Humulus


Biological context of Humulus


Anatomical context of Humulus


Associations of Humulus with chemical compounds

  • Identification and characterization of the major allergen of the Humulus japonicus pollen [12].
  • Humulon, one of the bitters in the hop, was isolated from the female flowers of Humulus lupulus [13].
  • Xanthohumol (XN) is the major prenylated flavonoid of the female inflorescences (cones) of the hop plant (Humulus lupulus) [14].
  • The female flowers of hops (Humulus lupulus L.) used to flavor beer contain the prenylated flavonoids xanthohumol (XN) and isoxanthohumol (IX) [15].
  • Expression of allene oxide cyclase and accumulation of jasmonates during organogenic nodule formation from hop (Humulus lupulus var. Nugget) internodes [16].

Gene context of Humulus

  • In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus [17].
  • The expression and subcellular localization of extracellular signal-regulated kinase 1 or 2 (ERK1/2) homologues (HLERK1/2) during the process of organogenic nodule formation in Humulus lupulus var [18].
  • In the present study, we investigated the inhibitory effect of extracts from Humulus lupulus L. on both the production of NO and the expression of inducible NO synthase (iNOS) in mouse macrophage RAW 264.7 cells [19].
  • The LPS/IFN-gamma-induced production of NO and expression of iNOS were significantly inhibited by the ethyl acetate soluble fraction of Humulus lupulus L [19].
  • Neurological stamp. Humulus lupulus (hop) [20].

Analytical, diagnostic and therapeutic context of Humulus


  1. The antimycobacterial components of hops (Humulus lupulus) and their dereplication. Stavri, M., Schneider, R., O'Donnell, G., Lechner, D., Bucar, F., Gibbons, S. Phytotherapy research : PTR. (2004) [Pubmed]
  2. Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway. Pan, L., Becker, H., Gerhäuser, C. Molecular nutrition & food research. (2005) [Pubmed]
  3. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. Milligan, S.R., Kalita, J.C., Pocock, V., Van De Kauter, V., Stevens, J.F., Deinzer, M.L., Rong, H., De Keukeleire, D. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  4. Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer. Vanhoecke, B., Derycke, L., Van Marck, V., Depypere, H., De Keukeleire, D., Bracke, M. Int. J. Cancer (2005) [Pubmed]
  5. Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. Dietz, B.M., Kang, Y.H., Liu, G., Eggler, A.L., Yao, P., Chadwick, L.R., Pauli, G.F., Farnsworth, N.R., Mesecar, A.D., van Breemen, R.B., Bolton, J.L. Chem. Res. Toxicol. (2005) [Pubmed]
  6. In vitro antiplasmodial activity of prenylated chalcone derivatives of hops (Humulus lupulus) and their interaction with haemin. Frölich, S., Schubert, C., Bienzle, U., Jenett-Siems, K. J. Antimicrob. Chemother. (2005) [Pubmed]
  7. Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2'-hydroxychalcones as a novel antioxidant pharmacophore. Stevens, J.F., Miranda, C.L., Frei, B., Buhler, D.R. Chem. Res. Toxicol. (2003) [Pubmed]
  8. Construction of gene expression system in hop (Humulus lupulus) lupulin gland using valerophenone synthase promoter. Okada, Y., Saeki, K., Inaba, A., Suda, N., Kaneko, T., Ito, K. J. Plant Physiol. (2003) [Pubmed]
  9. Incidence and inheritance of resistance to METI-acaricides in European strains of the two-spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae). Devine, G.J., Barber, M., Denholm, I. Pest Manag. Sci. (2001) [Pubmed]
  10. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes. Nikolic, D., Li, Y., Chadwick, L.R., Grubjesic, S., Schwab, P., Metz, P., van Breemen, R.B. Drug Metab. Dispos. (2004) [Pubmed]
  11. New insight in the neuropharmacological activity of Humulus lupulus L. Zanoli, P., Rivasi, M., Zavatti, M., Brusiani, F., Baraldi, M. Journal of ethnopharmacology. (2005) [Pubmed]
  12. Identification and characterization of the major allergen of the Humulus japonicus pollen. Park, J.W., Ko, S.H., Kim, C.W., Jeoung, B.J., Hong, C.S. Clin. Exp. Allergy (1999) [Pubmed]
  13. Humulon, a bitter in the hop, inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Yasukawa, K., Takeuchi, M., Takido, M. Oncology (1995) [Pubmed]
  14. In vitro biotransformation of xanthohumol, a flavonoid from hops (Humulus lupulus), by rat liver microsomes. Yilmazer, M., Stevens, J.F., Deinzer, M.L., Buhler, D.R. Drug Metab. Dispos. (2001) [Pubmed]
  15. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. Nikolic, D., Li, Y., Chadwick, L.R., Pauli, G.F., van Breemen, R.B. Journal of mass spectrometry : JMS. (2005) [Pubmed]
  16. Expression of allene oxide cyclase and accumulation of jasmonates during organogenic nodule formation from hop (Humulus lupulus var. Nugget) internodes. Fortes, A.M., Miersch, O., Lange, P.R., Malhó, R., Testillano, P.S., Risueño, M.d.e.l. .C., Wasternack, C., Pais, M.S. Plant Cell Physiol. (2005) [Pubmed]
  17. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Henderson, M.C., Miranda, C.L., Stevens, J.F., Deinzer, M.L., Buhler, D.R. Xenobiotica (2000) [Pubmed]
  18. Differential expression and cellular localization of ERKs during organogenic nodule formation from internodes of Humulus lupulus var. Nugget. Sousa Silva, M., Margarida Fortes, A., Sanchéz Testillanob, P., Risueño, M.d.e.l. .C., Salom'e Pais, M. Eur. J. Cell Biol. (2004) [Pubmed]
  19. Inhibitors of nitric oxide production from hops (Humulus lupulus L.). Zhao, F., Nozawa, H., Daikonnya, A., Kondo, K., Kitanaka, S. Biol. Pharm. Bull. (2003) [Pubmed]
  20. Neurological stamp. Humulus lupulus (hop). Haas, L.F. J. Neurol. Neurosurg. Psychiatr. (1995) [Pubmed]
  21. Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.). Sakano, Y., Okada, Y., Matsunaga, A., Suwama, T., Kaneko, T., Ito, K., Noguchi, H., Abe, I. Phytochemistry (2004) [Pubmed]
  22. Xanthohumol stimulates iodide uptake in rat thyroid-derived FRTL-5 cells. Radović, B., Schmutzler, C., Köhrle, J. Molecular nutrition & food research. (2005) [Pubmed]
  23. Cloning, expression, and characterization of pollen allergens from Humulus scandens (Lour) Merr and Ambrosia artemisiifolia L. Tao, A.L., He, S.H. Acta Pharmacol. Sin. (2005) [Pubmed]
WikiGenes - Universities