Disease relevance of Aesculus

• Randomized trials that compare the effects of treatment with saponins from Chinese Buckeye Seed to placebo treatment, to lack of treatment, to non-specific treatment, or to mannitol treatment for cerebral edema were identified with electronic and manual searches [1].
• Contact dermatitis to extract of horse chestnut (esculin) [2].
• Oxerutins (O-(beta-hydroxyethyl)rutosides, HR, Venoruton) and horse chestnut extract (HCE) are active principles of first priority for the pharmacological treatment of chronic venous insufficiency (CVI) [3].

High impact information on Aesculus

• This drug, available in twenty countries under various names, contains phenopyrazone, horse-chestnut extract, and cardiac glycosides extracted from various plants [4].
• Isolation and characterization of esters of indole-3-acetic acid from the liquid endosperm of the horse chestnut (Aesculus species) [5].
• The outermost phellems of Abies alba Mill., Acer pseudoplatanus L., Aesculus hippocastanum L., Betula potaninii L.C. Hue and Sambucus nigra L. have been isolated enzymatically, resulting in membranes with five to seven heavily suberized cork cell layers [6].
• Embedded waxes amounted to 3% ( Aesculus) and up to 35% ( Betula) of the dry weight but affected water permeance only to a small degree [6].
• The contractile responses were tested with phenylephrine (an alpha-adrenergic receptor agonist) and aescin, a clinically used phlebotonic drug derived from horse chestnut extract [7].

Chemical compound and disease context of Aesculus

• Triterpene and steroid saponins and sapogenins of medicinal plants (Aesculus hippocastanum L., Hedera helix L., Ruscus aculeatus L.) are claimed to be effective for the treatment/prevention of venous insufficiency [8].

Biological context of Aesculus

• Seasonal variations in the concentrations of cadmium, copper, lead and zinc in leaves of the horse chesnut (Aesculus hippocastanum L.) [9].
• It was previously reported that escin Ib isolated from horse chestnut inhibited gastric emptying (GE) in mice, in which the capsaicin-sensitive sensory nerves (CPSN), the central nervous system and endogenous prostaglandins (PGs) were involved [10].
• Bioavailability of beta-aescin from horse chestnut seed extract: comparative clinical studies of two Galenic formulations [11].

Anatomical context of Aesculus

• The horse-chestnut saponin Aescin, an anti-exudative compound, induces contraction of isolated portal vein of rat and rabbit [12].

Associations of Aesculus with chemical compounds

• Proceedings: Further results concerning the efficacy and the mechanism of action of the horse chestnut saponin escin [13].
• Leaf phenology of subcanopy individuals of both Aesculus glabra and Acer saccharum responded to gap conditions [14].
• Two new triterpenoid glycosides isolated from Aesculus assamica GRIFF [15].
• A bioassay-guided fractionation of an ethanol extract of the seeds of Aesculus chinensis led to the isolation of two new flavanoids (1 and 2), along with eight known ones (3-10) [16].
• This study investigated the interactions among water content, rapid (nonequilibrium) cooling to -196 degrees C using isopentane or subcooled nitrogen, and survival of embryonic axes of Aesculus hippocastanum [17].

Gene context of Aesculus

• Bioflavinoids from buckwheat and horse chestnut are used for varicose veins, and silymarin is used for liver protection [18].
• Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals [19].

Analytical, diagnostic and therapeutic context of Aesculus

• Animal experiments on the question of the renal toleration of the horse chestnut saponin aescin [20].

References