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MeSH Review


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Disease relevance of Aesculus


High impact information on Aesculus

  • This drug, available in twenty countries under various names, contains phenopyrazone, horse-chestnut extract, and cardiac glycosides extracted from various plants [4].
  • Isolation and characterization of esters of indole-3-acetic acid from the liquid endosperm of the horse chestnut (Aesculus species) [5].
  • The outermost phellems of Abies alba Mill., Acer pseudoplatanus L., Aesculus hippocastanum L., Betula potaninii L.C. Hue and Sambucus nigra L. have been isolated enzymatically, resulting in membranes with five to seven heavily suberized cork cell layers [6].
  • Embedded waxes amounted to 3% ( Aesculus) and up to 35% ( Betula) of the dry weight but affected water permeance only to a small degree [6].
  • The contractile responses were tested with phenylephrine (an alpha-adrenergic receptor agonist) and aescin, a clinically used phlebotonic drug derived from horse chestnut extract [7].

Chemical compound and disease context of Aesculus


Biological context of Aesculus


Anatomical context of Aesculus


Associations of Aesculus with chemical compounds

  • Proceedings: Further results concerning the efficacy and the mechanism of action of the horse chestnut saponin escin [13].
  • Leaf phenology of subcanopy individuals of both Aesculus glabra and Acer saccharum responded to gap conditions [14].
  • Two new triterpenoid glycosides isolated from Aesculus assamica GRIFF [15].
  • A bioassay-guided fractionation of an ethanol extract of the seeds of Aesculus chinensis led to the isolation of two new flavanoids (1 and 2), along with eight known ones (3-10) [16].
  • This study investigated the interactions among water content, rapid (nonequilibrium) cooling to -196 degrees C using isopentane or subcooled nitrogen, and survival of embryonic axes of Aesculus hippocastanum [17].

Gene context of Aesculus


Analytical, diagnostic and therapeutic context of Aesculus


  1. Saponins from Chinese Buckeye Seed reduce cerebral edema: metaanalysis of randomized controlled trials. Zhou, Y., Hui, X., Li, N., Zhuang, W., Liu, G., Wu, T., Wei, M., Wu, X. Planta Med. (2005) [Pubmed]
  2. Contact dermatitis to extract of horse chestnut (esculin). Comaish, J.S., Kersey, P.J. Contact Derm. (1980) [Pubmed]
  3. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Rehn, D., Unkauf, M., Klein, P., Jost, V., Lücker, P.W. Arzneimittel-Forschung. (1996) [Pubmed]
  4. Drug-induced pseudolupus. Grob, P.J., Müller-Schoop, J.W., Häcki, M.A., Joller-Jemelka, H.I. Lancet (1975) [Pubmed]
  5. Isolation and characterization of esters of indole-3-acetic acid from the liquid endosperm of the horse chestnut (Aesculus species). Domagalski, W., Schulze, A., Bandurski, R.S. Plant Physiol. (1987) [Pubmed]
  6. Water and oxygen permeance of phellems isolated from trees: the role of waxes and lenticels. Groh, B., Hübner, C., Lendzian, K.J. Planta (2002) [Pubmed]
  7. Responsiveness of human varicose saphenous veins to vasoactive agents. Brunner, F., Hoffmann, C., Schuller-Petrovic, S. British journal of clinical pharmacology. (2001) [Pubmed]
  8. Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. Facino, R.M., Carini, M., Stefani, R., Aldini, G., Saibene, L. Arch. Pharm. (Weinheim) (1995) [Pubmed]
  9. Seasonal variations in the concentrations of cadmium, copper, lead and zinc in leaves of the horse chesnut (Aesculus hippocastanum L.). Kim, N.D., Fergusson, J.E. Environ. Pollut. (1994) [Pubmed]
  10. Possible involvement of dopamine and dopamine2 receptors in the inhibitions of gastric emptying by escin Ib in mice. Matsuda, H., Li, Y., Yoshikawa, M. Life Sci. (2000) [Pubmed]
  11. Bioavailability of beta-aescin from horse chestnut seed extract: comparative clinical studies of two Galenic formulations. Bässler, D., Okpanyi, S., Schrödter, A., Loew, D., Schürer, M., Schulz, H.U. Advances in therapy. (2003) [Pubmed]
  12. The mode of action of aescin and the release of prostaglandins. Berti, F., Omini, C., Longiave, D. Prostaglandins (1977) [Pubmed]
  13. Proceedings: Further results concerning the efficacy and the mechanism of action of the horse chestnut saponin escin. Rothkopf, M. Naunyn Schmiedebergs Arch. Pharmacol. (1975) [Pubmed]
  14. Differences in leaf phenology between juvenile and adult trees in a temperate deciduous forest. Augspurger, C.K., Bartlett, E.A. Tree Physiol. (2003) [Pubmed]
  15. Two new triterpenoid glycosides isolated from Aesculus assamica GRIFF. Liu, H., Zhang, X., Gao, H., Wang, N., Jin, S., Cai, B., Yao, X., Cai, G. Chem. Pharm. Bull. (2005) [Pubmed]
  16. Antiviral flavonoids from the seeds of Aesculus chinensis. Wei, F., Ma, S.C., Ma, L.Y., But, P.P., Lin, R.C., Khan, I.A. J. Nat. Prod. (2004) [Pubmed]
  17. Interactions among water content, rapid (nonequilibrium) cooling to -196 degrees C, and survival of embryonic axes of Aesculus hippocastanum L. seeds. Wesley-Smith, J., Walters, C., Pammenter, N.W., Berjak, P. Cryobiology (2001) [Pubmed]
  18. From medical herbalism to phytotherapy in dermatology: back to the future. Dattner, A.M. Dermatologic therapy. (2003) [Pubmed]
  19. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Matsuda, H., Li, Y., Murakami, T., Ninomiya, K., Yamahara, J., Yoshikawa, M. Biol. Pharm. Bull. (1997) [Pubmed]
  20. Animal experiments on the question of the renal toleration of the horse chestnut saponin aescin. Rothkopf, M., Vogel, G., Lang, W., Leng, E. Arzneimittel-Forschung. (1977) [Pubmed]
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