Disease relevance of Aescin

• Proceedings: Influence of calcium ions and aescin on transport processes in Yoshida ascites tumor cells [1].
• OBJECTIVE: To describe a 57-year-old man employed in the pharmaceutical industry who developed bronchial asthma while working with products such as Plantago ovata and aescin, an active ingredient with anti-inflammatory and venotonic properties [2].
• Contact urticaria due to aescin [3].
• Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel on transcutaneous PO2 in venous insufficiency [4].
• Variations in plasma free radicals with topical aescin + essential phospholipids gel in venous hypertension: new clinical data [5].

High impact information on Aescin

• RESULTS: The results of these tests, including specific inhalation challenge, confirmed the diagnosis of occupational asthma due to aescin exposure, whereas the results of specific challenge with P. ovata, a known cause of occupational asthma, were negative [2].
• The contractile responses were tested with phenylephrine (an alpha-adrenergic receptor agonist) and aescin, a clinically used phlebotonic drug derived from horse chestnut extract [6].
• In studies on the membranlytic action of various saponins on mycelium of Botrytis cinerea and Rhizoctonia solani digitonin, alpha-hederin and tomatin caused considerable leakage of free amino acids, while aescin and theasaponin were less effective [7].
• All simulations were verified by CO2 extractions of the secondary roots of Harpagophytum procumbens (harpagoside, stachyose) and the seeds of Aesculus hippocastanum (aescin) [8].
• The horse-chestnut saponin Aescin, an anti-exudative compound, induces contraction of isolated portal vein of rat and rabbit [9].

Chemical compound and disease context of Aescin

• A gel including aescin, essential phospholipids (EPL), and heparin (EG) has been used for many years for local treatment of venous, microcirculatory alterations (varicose veins, chronic venous insufficiency) [4].

Biological context of Aescin

• Aescin: pharmacology, pharmacokinetics and therapeutic profile [10].
• Measurement of the bioavailability of aescin-containing extracts [11].
• Percutaneous absorption of aescin was measured following application of an aqueous solution of tritiated sodium aescinate to the ventral skin of pigs [12].
• Efficacy of topical treatment with aescin + essential phospholipids gel on capillary fragility [13].

Anatomical context of Aescin

• Taraxaci and aescin - induced changes in the mechanical activity (isotonic registration) of guinea pig and rat ureter, detrusor and vas deferens preparations when applied at concentrations of 10 ng to 100 microgram/ml [14].

Associations of Aescin with other chemical compounds

• Most of the beneficial effects of horse chestnut are attributed to its principal component beta-escin or aescin [15].

Analytical, diagnostic and therapeutic context of Aescin

• This study was carried out to compare the efficacy (oedema reduction) and safety of compression stockings class II and dried horse chestnut seed extract (HCSE, 50 mg aescin, twice daily) [16].
• HPLC determinations of the aescin contents in calli and embryoids from leaf explants of AESCULUS HIPPOCASTANUM L. were carried out in order to determine whether it was possible to obtain aescin-forming proliferations IN VITRO [17].
• Animal experiments on the question of the renal toleration of the horse chestnut saponin aescin [18].

References