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Gene Review

PVR  -  poliovirus receptor

Homo sapiens

Synonyms: CD155, HVED, NECL-5, NECL5, Necl-5, ...
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Disease relevance of PVR


Psychiatry related information on PVR

  • Incompetent patient (PVS): decision-making, courts and the family -- In re Tavel [5].
  • While there is growing support for withdrawing/withholding food and water (assisted nutrition and hydration, or "AHN") from people described as being in a "persistent vegetative state" ("PVS") and people with other profound neurological impairments, such as advanced dementia, the issue remains controversial, and for many, unresolved [6].

High impact information on PVR


Chemical compound and disease context of PVR

  • The fit was confirmed by the location of carbohydrate moieties in the CD155 glycoprotein, the conserved properties of elbow angles in the structures of cell surface molecules with Ig-like folds, and the concordance with prior results of CD155 and poliovirus mutagenesis [10].
  • In the patients with pulmonary hypertension, PVR fell significantly after inhaled NO and after prostacyclin [11].
  • Treatment of SOFIA cells with 5-azacytidine restored susceptibility to poliovirus infection, which correlated with the appearance of PVRs at the cell surface, as detected with anti-PVR monoclonal antibody D171 [12].
  • Eleven patients, with advanced chronic obstructive lung disease (COLD), received an infusion of the calcium antagonist felodipine at a rate of 0.9 mg/h. Pulmonary and systemic vascular resistances (PVR and SVR) at rest were reduced by 18% (p less than 0.05) and 33% (p less than 0.001), respectively [13].
  • METHODS: Forty-one men over the age of 50 years with an American Urological Association (AUA) symptom score greater than 8, postvoid residual urine volume (PVR) less than 300 mL, and no clinical or biochemical evidence of prostate cancer were treated with terazosin independent of the baseline PFR [14].

Biological context of PVR


Anatomical context of PVR


Associations of PVR with chemical compounds


Physical interactions of PVR


Regulatory relationships of PVR

  • PVR cell surface expression was detected on most mononuclear cells expressing CD14, a marker for mononuclear phagocytes [25].

Other interactions of PVR

  • HIgR shares its ectodomain with and appears to be an alternative splice variant of the previously described protein PRR-1 (poliovirus receptor-related protein) [26].
  • Comparison of the deduced amino acid sequences of PVR orthologs revealed that the NH(2)-terminal immunoglobulin-like domain (domain 1), which is the virus binding site in the human PVR, is highly variable among species, whereas that of PRR1 is highly conserved [27].
  • One of them, named necl-5, which does not homophilically trans-interact, but heterophilically trans-interacts with nectin-3, regulates cell migration and adhesion [28].
  • These data support the interpretation that CD155 (and related proteins) are physically associated with CD44 on monocyte cell surfaces [29].
  • Overall, our findings do not support a role of HVEB and PVR genes in the development of MS [30].

Analytical, diagnostic and therapeutic context of PVR


  1. Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). Pende, D., Spaggiari, G.M., Marcenaro, S., Martini, S., Rivera, P., Capobianco, A., Falco, M., Lanino, E., Pierri, I., Zambello, R., Bacigalupo, A., Mingari, M.C., Moretta, A., Moretta, L. Blood (2005) [Pubmed]
  2. Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction. Castriconi, R., Dondero, A., Corrias, M.V., Lanino, E., Pende, D., Moretta, L., Bottino, C., Moretta, A. Cancer Res. (2004) [Pubmed]
  3. The poliovirus receptor CD155 mediates cell-to-matrix contacts by specifically binding to vitronectin. Lange, R., Peng, X., Wimmer, E., Lipp, M., Bernhardt, G. Virology (2001) [Pubmed]
  4. Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog. Solecki, D.J., Gromeier, M., Mueller, S., Bernhardt, G., Wimmer, E. J. Biol. Chem. (2002) [Pubmed]
  5. Incompetent patient (PVS): decision-making, courts and the family -- In re Tavel. Grubb, A. Medical law review. (1997) [Pubmed]
  6. Masked intentions: the masquerade of killing thoughts used to justify dehydrating and starving people in a "persistent vegetative state" and people with other profound neurological impairments. Hildebrand, A.J. Issues in law & medicine. (2000) [Pubmed]
  7. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Mendelsohn, C.L., Wimmer, E., Racaniello, V.R. Cell (1989) [Pubmed]
  8. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Geraghty, R.J., Krummenacher, C., Cohen, G.H., Eisenberg, R.J., Spear, P.G. Science (1998) [Pubmed]
  9. DNAM-1 and PVR regulate monocyte migration through endothelial junctions. Reymond, N., Imbert, A.M., Devilard, E., Fabre, S., Chabannon, C., Xerri, L., Farnarier, C., Cantoni, C., Bottino, C., Moretta, A., Dubreuil, P., Lopez, M. J. Exp. Med. (2004) [Pubmed]
  10. Interaction of the poliovirus receptor with poliovirus. He, Y., Bowman, V.D., Mueller, S., Bator, C.M., Bella, J., Peng, X., Baker, T.S., Wimmer, E., Kuhn, R.J., Rossmann, M.G. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  11. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Pepke-Zaba, J., Higenbottam, T.W., Dinh-Xuan, A.T., Stone, D., Wallwork, J. Lancet (1991) [Pubmed]
  12. Down regulation of poliovirus receptor RNA in HeLa cells resistant to poliovirus infection. Kaplan, G., Racaniello, V.R. J. Virol. (1991) [Pubmed]
  13. Cardiac function and central haemodynamics in severe chronic obstructive lung disease. Acute and long-term effects of felodipine. Bratel, T., Hedenstierna, G., Lundquist, H., Nyquist, O., Ripe, E. Eur. Respir. J. (1988) [Pubmed]
  14. Effect of terazosin on prostatism in men with normal and abnormal peak urinary flow rates. Lepor, H., Nieder, A., Feser, J., O'Connell, C., Dixon, C. Urology (1997) [Pubmed]
  15. Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts. Oda, T., Ohka, S., Nomoto, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  16. Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. Mueller, S., Cao, X., Welker, R., Wimmer, E. J. Biol. Chem. (2002) [Pubmed]
  17. The poliovirus receptor protein is produced both as membrane-bound and secreted forms. Koike, S., Horie, H., Ise, I., Okitsu, A., Yoshida, M., Iizuka, N., Takeuchi, K., Takegami, T., Nomoto, A. EMBO J. (1990) [Pubmed]
  18. Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. Ohka, S., Matsuda, N., Tohyama, K., Oda, T., Morikawa, M., Kuge, S., Nomoto, A. J. Virol. (2004) [Pubmed]
  19. N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor. Zibert, A., Wimmer, E. J. Virol. (1992) [Pubmed]
  20. Nectins and nectin-like molecules: roles in cell adhesion, polarization, movement, and proliferation. Ogita, H., Takai, Y. IUBMB Life (2006) [Pubmed]
  21. Actuarial comparison of Hancock porcine and prosthetic disc valves for isolated mitral valve replacement. Cohn, L.H., Sanders, J.H., Collins, J.J. Circulation (1976) [Pubmed]
  22. Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Sato, T., Irie, K., Ooshio, T., Ikeda, W., Takai, Y. Genes Cells (2004) [Pubmed]
  23. Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry. Krummenacher, C., Nicola, A.V., Whitbeck, J.C., Lou, H., Hou, W., Lambris, J.D., Geraghty, R.J., Spear, P.G., Cohen, G.H., Eisenberg, R.J. J. Virol. (1998) [Pubmed]
  24. Identification and characterization of the cis-acting elements of the human CD155 gene core promoter. Solecki, D., Wimmer, E., Lipp, M., Bernhardt, G. J. Biol. Chem. (1999) [Pubmed]
  25. Poliovirus receptor on human blood cells: a possible extraneural site of poliovirus replication. Freistadt, M.S., Fleit, H.B., Wimmer, E. Virology (1993) [Pubmed]
  26. The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells. Cocchi, F., Menotti, L., Mirandola, P., Lopez, M., Campadelli-Fiume, G. J. Virol. (1998) [Pubmed]
  27. Host range of poliovirus is restricted to simians because of a rapid sequence change of the poliovirus receptor gene during evolution. Ida-Hosonuma, M., Sasaki, Y., Toyoda, H., Nomoto, A., Gotoh, O., Yonekawa, H., Koike, S. Arch. Virol. (2003) [Pubmed]
  28. Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Takai, Y., Irie, K., Shimizu, K., Sakisaka, T., Ikeda, W. Cancer Sci. (2003) [Pubmed]
  29. Physical association between CD155 and CD44 in human monocytes. Freistadt, M.S., Eberle, K.E. Mol. Immunol. (1997) [Pubmed]
  30. The role of the polio virus receptor and the herpesvirus entry mediator B genes for the development of MS. Rosche, B., Cepok, S., Stei, S., Vogel, F., Grummel, V., Hoffmann, S., Kroner, A., Mäurer, M., Rieckmann, P., Sommer, N., Hemmer, B. J. Neuroimmunol. (2004) [Pubmed]
  31. Immunofluorescence analysis of poliovirus receptor expression in Peyer's patches of humans, primates, and CD155 transgenic mice: implications for poliovirus infection. Iwasaki, A., Welker, R., Mueller, S., Linehan, M., Nomoto, A., Wimmer, E. J. Infect. Dis. (2002) [Pubmed]
  32. Identification of secreted CD155 isoforms. Baury, B., Masson, D., McDermott, B.M., Jarry, A., Blottière, H.M., Blanchardie, P., Laboisse, C.L., Lustenberger, P., Racaniello, V.R., Denis, M.G. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  33. Cardiac involvement in thalassemia intermedia: a multicenter study. Aessopos, A., Farmakis, D., Karagiorga, M., Voskaridou, E., Loutradi, A., Hatziliami, A., Joussef, J., Rombos, J., Loukopoulos, D. Blood (2001) [Pubmed]
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