Disease relevance of Torque teno virus

• To clarify the effect of SENV infection on coexisting chronic hepatitis C and the effect of interferon alfa (IFN-alpha) therapy on SENV replication, SENV DNA was quantitated by polymerase chain reaction in serum samples from 186 patients with chronic hepatitis C [1].
• SEN virus (SEN-V) is a recently identified single-stranded, circular DNA virus [2].
• Polymerase chain reaction-based prevalence of hepatitis A, hepatitis E and TT viruses in sewage from an endemic area [3].
• Viral protein 2 (VP2) of chicken anemia virus (CAV) and ORF2 of TT virus have been shown to possess DSP activity in vitro [4].
• In a pilot study we analysed 162 biopsy specimens from various human cancers and from colon polyps for the presence of TT virus related sequences by polymerase chain reaction using three sets of nested primers for TT virus detection [5].

High impact information on Torque teno virus

• TT virus (TTV) was first described in 1997 by representational difference analysis of sera from non-A to non-G posttransfusion hepatitis patients and hence intensively investigated as a possible addition to the list of hepatitis-inducing viruses [6].
• In coinfected patients, SENV responses to IFN-alpha were significantly better in those who failed to clear HCV RNA than in those who lost HCV RNA (P =.013) [1].
• We show that the CAV VP2 amino acid sequence has some similarity to a number of eukaryotic, receptor, protein-tyrosine phosphatase (PTPase) alpha proteins as well as to a cluster of human TT viruses within the Sanban group [7].
• Prototype TTV formed group 2, PMV formed group 3, and SENV, SANBAN, and TUS01 isolates formed group 4, the most recently evolved group [8].
• Effect of TT virus infection on hepatocellular carcinoma development: results of a Euro-Asian survey [9].

Chemical compound and disease context of Torque teno virus

• No significant differences in alanine aminotransferase or bilirubin concentrations were observed between the groups of patients with or without TT virus infection [10].
• Prevalence studies of the recently identified TT virus (TTV) have suggested that parenteral transmission is a common route of infection, but other routes also appear likely [11].
• N22 sequence in serum banded at a sucrose density of 1.26 g/cm3, indicating its association with a viral particle which was designated TT virus (TTV) [12].
• RESULTS: SENV DNA was detected in 5 of 45(11.1%) cases after 12 mo they received lamivudine treatment [13].
• This study investigated the responses of TT virus (TTV) and hepatitis C virus (HCV) to PEG-IFN plus ribavirin therapy [14].

Biological context of Torque teno virus

• Sera from French in-patients were tested for the presence of the TT virus (TTV) genome using PCR and degenerate primers located in ORF1 [15].
• To investigate the vertical transmission of the newly described TT virus (TTV), serum and breast milk samples from 46 women as well as sera from their 47 newborns were examined for the presence of TTV DNA by PCR [16].
• The largest open reading frame of KAV (ORF 1) was about 40 aa shorter than that of other TT-viruses [17].
• We assayed serum TT virus DNA by seminested polymerase chain reactions and also examined the genotypes of this virus [18].

Anatomical context of Torque teno virus

• Visualization of TT virus particles recovered from the sera and feces of infected humans [19].

Gene context of Torque teno virus

• Influence of TT virus co-infection on IFN-beta therapy in patients with chronic hepatitis C [20].
• OBJECTIVES: To determine the prevalence of TT virus (TTV) in a population of Danish hemodialysis patients and evaluate possible relations between TTV infection and elevated levels of C-reactive protein (CRP) and hypo-response to treatment with erythropoietin (EPO) [21].
• Use of a TT virus ORF1 recombinant protein to detect anti-TT virus antibodies in human sera [22].
• The presences of HBV DNA, HCV RNA, and SENV DNA in stored serum samples were detected with the use of semi-nested polymerase chain reaction amplification [23].
• Analyzing both LTR and env regions, the family's sequences clustered with isolates of Brazilian intravenous drug users and transfusion transmitted virus [24].

Analytical, diagnostic and therapeutic context of Torque teno virus

• The aim of this study was to evaluate the association between SENV infection and the risk of HCC by conducting a hospital-based, case-control study among Thai patients [23].
• Molecular epidemiology of TT virus in Italy and phylogenesis of viral isolates from subjects at different risk for parenteral exposure [25].
• METHODS: The presence of SENV was investigated in 171 hemodialysis patients and in 163 controls by using a polymerase chain reaction based methodology, with which the specificity of amplified products was detected by hybridization with probes specific for each variant [26].
• Our aim was to clarify the effect on treatment outcome of coinfection with SEN virus in patients with hepatitis B during lamivudine therapy [13].

References