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MeSH Review

Torque teno virus

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Disease relevance of Torque teno virus


High impact information on Torque teno virus

  • TT virus (TTV) was first described in 1997 by representational difference analysis of sera from non-A to non-G posttransfusion hepatitis patients and hence intensively investigated as a possible addition to the list of hepatitis-inducing viruses [6].
  • In coinfected patients, SENV responses to IFN-alpha were significantly better in those who failed to clear HCV RNA than in those who lost HCV RNA (P =.013) [1].
  • We show that the CAV VP2 amino acid sequence has some similarity to a number of eukaryotic, receptor, protein-tyrosine phosphatase (PTPase) alpha proteins as well as to a cluster of human TT viruses within the Sanban group [7].
  • Prototype TTV formed group 2, PMV formed group 3, and SENV, SANBAN, and TUS01 isolates formed group 4, the most recently evolved group [8].
  • Effect of TT virus infection on hepatocellular carcinoma development: results of a Euro-Asian survey [9].

Chemical compound and disease context of Torque teno virus


Biological context of Torque teno virus


Anatomical context of Torque teno virus

  • Visualization of TT virus particles recovered from the sera and feces of infected humans [19].

Gene context of Torque teno virus

  • Influence of TT virus co-infection on IFN-beta therapy in patients with chronic hepatitis C [20].
  • OBJECTIVES: To determine the prevalence of TT virus (TTV) in a population of Danish hemodialysis patients and evaluate possible relations between TTV infection and elevated levels of C-reactive protein (CRP) and hypo-response to treatment with erythropoietin (EPO) [21].
  • Use of a TT virus ORF1 recombinant protein to detect anti-TT virus antibodies in human sera [22].
  • The presences of HBV DNA, HCV RNA, and SENV DNA in stored serum samples were detected with the use of semi-nested polymerase chain reaction amplification [23].
  • Analyzing both LTR and env regions, the family's sequences clustered with isolates of Brazilian intravenous drug users and transfusion transmitted virus [24].

Analytical, diagnostic and therapeutic context of Torque teno virus


  1. SEN virus: response to interferon alfa and influence on the severity and treatment response of coexistent hepatitis C. Umemura, T., Alter, H.J., Tanaka, E., Orii, K., Yeo, A.E., Shih, J.W., Matsumoto, A., Yoshizawa, K., Kiyosawa, K. Hepatology (2002) [Pubmed]
  2. SEN virus infection and its relationship to transfusion-associated hepatitis. Umemura, T., Yeo, A.E., Sottini, A., Moratto, D., Tanaka, Y., Wang, R.Y., Shih, J.W., Donahue, P., Primi, D., Alter, H.J. Hepatology (2001) [Pubmed]
  3. Polymerase chain reaction-based prevalence of hepatitis A, hepatitis E and TT viruses in sewage from an endemic area. Vaidya, S.R., Chitambar, S.D., Arankalle, V.A. J. Hepatol. (2002) [Pubmed]
  4. Mutation of chicken anemia virus VP2 differentially affects serine/threonine and tyrosine protein phosphatase activities. Peters, M.A., Jackson, D.C., Crabb, B.S., Browning, G.F. J. Gen. Virol. (2005) [Pubmed]
  5. Heterogeneity of TT virus related sequences isolated from human tumour biopsy specimens. de Villiers, E.M., Schmidt, R., Delius, H., zur Hausen, H. J. Mol. Med. (2002) [Pubmed]
  6. Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans. Bendinelli, M., Pistello, M., Maggi, F., Fornai, C., Freer, G., Vatteroni, M.L. Clin. Microbiol. Rev. (2001) [Pubmed]
  7. Chicken anemia virus VP2 is a novel dual specificity protein phosphatase. Peters, M.A., Jackson, D.C., Crabb, B.S., Browning, G.F. J. Biol. Chem. (2002) [Pubmed]
  8. Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN virus) and its relationship to the TT virus family. Tanaka, Y., Primi, D., Wang, R.Y., Umemura, T., Yeo, A.E., Mizokami, M., Alter, H.J., Shih, J.W. J. Infect. Dis. (2001) [Pubmed]
  9. Effect of TT virus infection on hepatocellular carcinoma development: results of a Euro-Asian survey. Pineau, P., Meddeb, M., Raselli, R., Qin, L.X., Terris, B., Tang, Z.Y., Tiollais, P., Mazzaferro, V., Dejean, A. J. Infect. Dis. (2000) [Pubmed]
  10. Prevalence and clinical characteristics of TT virus (TTV) in patients with sporadic acute hepatitis of unknown etiology. Parquet, M.C., Yatsuhashi, H., Koga, M., Inoue, O., Matsumoto, T., Hamada, R., Igarashi, A., Yano, M. J. Hepatol. (1999) [Pubmed]
  11. High carriage rate of TT virus in the cervices of pregnant women. Chan, P.K., Tam, W.H., Yeo, W., Cheung, J.L., Zhong, S., Cheng, A.F. Clin. Infect. Dis. (2001) [Pubmed]
  12. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Nishizawa, T., Okamoto, H., Konishi, K., Yoshizawa, H., Miyakawa, Y., Mayumi, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  13. Effect of SEN virus coinfection on outcome of lamivudine therapy in patients with hepatitis B. Xu, D., Tian, D.Y., Zhang, Z.G., Chen, H.Y., Song, P.H. World J. Gastroenterol. (2004) [Pubmed]
  14. Response of TT virus to IFN plus ribavirin treatment in patients with chronic hepatitis C. Moreno, J., Moraleda, G., Barcena, R., Mateos, M., del Campo, S. World J. Gastroenterol. (2004) [Pubmed]
  15. Determination and phylogenetic analysis of partial sequences from TT virus isolates. Biagini, P., Gallian, P., Attoui, H., Cantaloube, J.F., de Micco, P., de Lamballerie, X. J. Gen. Virol. (1999) [Pubmed]
  16. Detection of TT virus DNA and GB virus type C/Hepatitis G virus RNA in serum and breast milk: determination of mother-to-child transmission. Schröter, M., Polywka, S., Zöllner, B., Schäfer, P., Laufs, R., Feucht, H.H. J. Clin. Microbiol. (2000) [Pubmed]
  17. Isolate KAV: a new genotype of the TT-virus family. Heller, F., Zachoval, R., Koelzer, A., Nitschko, H., Froesner, G.G. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  18. Prevalence of TT virus in patients with fulminant hepatic failure in Japan. Tanaka, M., Nishiguchi, S., Tanaka, T., Enomoto, M., Takeda, T., Shiomi, S., Kuroki, T., Otani, S. J. Gastroenterol. (1999) [Pubmed]
  19. Visualization of TT virus particles recovered from the sera and feces of infected humans. Itoh, Y., Takahashi, M., Fukuda, M., Shibayama, T., Ishikawa, T., Tsuda, F., Tanaka, T., Nishizawa, T., Okamoto, H. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  20. Influence of TT virus co-infection on IFN-beta therapy in patients with chronic hepatitis C. Yamada, T., Naitou, H., Morita, T. Kansenshogaku Zasshi (2002) [Pubmed]
  21. Presence and significance of TT virus in Danish patients on maintenance hemodialysis. Boysen, T., Christensen, J.K., Madsen, C.D., Eugen-Olsen, J., Christensen, L.S., Møller-Sørensen, H., Weber, A., Ladefoged, S.D., Krogsgaard, K. Scandinavian journal of urology and nephrology. (2003) [Pubmed]
  22. Use of a TT virus ORF1 recombinant protein to detect anti-TT virus antibodies in human sera. Ott, C., Duret, L., Chemin, I., Trépo, C., Mandrand, B., Komurian-Pradel, F. J. Gen. Virol. (2000) [Pubmed]
  23. SEN virus infection and the risk of hepatocellular carcinoma: a case-control study. Tangkijvanich, P., Theamboonlers, A., Sriponthong, M., Kullavanijaya, P., Poovorawan, Y. Am. J. Gastroenterol. (2003) [Pubmed]
  24. HTLV-2 horizontal and vertical transmission in a family from a Brazilian urban area: seroepidemiological, clinical and molecular study. Catalan-Soares, B., Barbosa-Stancioli, E.F., Alcantara, L.C., Carneiro-Proietti, A.B., Martins, M.L., Namen-Lopes, M.S., Galvão-Castro, B., Ferreira, C.E., Costa, M.C., Pinheiro, S.R., Proietti, F.A. AIDS Res. Hum. Retroviruses (2005) [Pubmed]
  25. Molecular epidemiology of TT virus in Italy and phylogenesis of viral isolates from subjects at different risk for parenteral exposure. Zehender, G., Manzin, A., De Maddalena, C., Colasante, C., Solforosi, L., Corsi, F., Bianchi-Bosisio, A., Girotto, M., Schirru, I., Russo, U., Galli, M., Clementi, M. J. Med. Virol. (2001) [Pubmed]
  26. High prevalence of SEN virus infection in patients on maintenance hemodialysis: frequent mixed infections with different variants and evidence for nosocomial transmission of the virus. Pirovano, S., Gregorini, G., Malacarne, F., Marini, M., Albertini, A., Imberti, L. Intervirology (2005) [Pubmed]
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