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MeSH Review

Hepatitis E

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Disease relevance of Hepatitis E


High impact information on Hepatitis E

  • Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses [6].
  • Both inocula contained 27- ato 34-nm-diameter viruslike particles (VLPs) that were specifically aggregated by acute-phase ET-NANBH sera [7].
  • WHsAg and DNA polymerase appeared to be more reliable indicators of infectivity than anti-WHc, woodchuck hepatitis e antigen (WHeAg) or anti-WHe [8].
  • An earlier study in our laboratory has demonstrated that the ORF3 protein of the hepatitis E virus expedites the secretion of alpha1 microglobulin, an immunosuppressant molecule [1].
  • The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin/bikunin precursor (AMBP) and expedites their export from the hepatocyte [9].

Chemical compound and disease context of Hepatitis E


Biological context of Hepatitis E


Gene context of Hepatitis E


Analytical, diagnostic and therapeutic context of Hepatitis E


  1. Enhanced alpha1 microglobulin secretion from Hepatitis E virus ORF3-expressing human hepatoma cells is mediated by the tumor susceptibility gene 101. Surjit, M., Oberoi, R., Kumar, R., Lal, S.K. J. Biol. Chem. (2006) [Pubmed]
  2. The phosphorylated form of the ORF3 protein of hepatitis E virus interacts with its non-glycosylated form of the major capsid protein, ORF2. Tyagi, S., Korkaya, H., Zafrullah, M., Jameel, S., Lal, S.K. J. Biol. Chem. (2002) [Pubmed]
  3. Severe hemolysis and renal failure in glucose-6-phosphate dehydrogenase deficient patients with hepatitis E. Abid, S., Khan, A.H. Am. J. Gastroenterol. (2002) [Pubmed]
  4. Expression and diagnostic utility of hepatitis E virus putative structural proteins expressed in insect cells. He, J., Tam, A.W., Yarbough, P.O., Reyes, G.R., Carl, M. J. Clin. Microbiol. (1993) [Pubmed]
  5. Viral hepatitis in the 1990s, Part III: Hepatitis C, hepatitis E, and other viruses. Carey, W.D., Patel, G. Cleveland Clinic journal of medicine. (1992) [Pubmed]
  6. Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses. Koonin, E.V., Gorbalenya, A.E., Purdy, M.A., Rozanov, M.N., Reyes, G.R., Bradley, D.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  7. Enterically transmitted non-A, non-B hepatitis: serial passage of disease in cynomolgus macaques and tamarins and recovery of disease-associated 27- to 34-nm viruslike particles. Bradley, D.W., Krawczynski, K., Cook, E.H., McCaustland, K.A., Humphrey, C.D., Spelbring, J.E., Myint, H., Maynard, J.E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  8. Woodchuck hepatitis virus: experimental infection and natural occurrence. Millman, I., Southam, L., Halbherr, T., Simmons, H., Kang, C.M. Hepatology (1984) [Pubmed]
  9. The ORF3 protein of hepatitis E virus interacts with liver-specific alpha1-microglobulin and its precursor alpha1-microglobulin/bikunin precursor (AMBP) and expedites their export from the hepatocyte. Tyagi, S., Surjit, M., Roy, A.K., Jameel, S., Lal, S.K. J. Biol. Chem. (2004) [Pubmed]
  10. Hepatitis E virus: no evidence of parenteral transmission in Finland. Pohjanpelto, P., Ebeling, F., Rasi, V., Hampl, H. Thromb. Haemost. (1995) [Pubmed]
  11. Hepatitis E virus infection in a cohort of patients with acute non-A, non-B hepatitis. Psichogiou, M.A., Tassopoulos, N.C., Papatheodoridis, G.V., Tzala, E., Klarmann, R., Witteler, H., Schlauder, G.G., Troonen, H., Hatzakis, A. J. Hepatol. (1995) [Pubmed]
  12. Persistent and transient antibody responses to hepatitis E virus detected by western immunoblot using open reading frame 2 and 3 and glutathione S-transferase fusion proteins. Li, F., Zhuang, H., Kolivas, S., Locarnini, S.A., Anderson, D.A. J. Clin. Microbiol. (1994) [Pubmed]
  13. Epidemic and sporadic hepatitis E virus transmission in West Kalimantan (Borneo), Indonesia. Corwin, A., Putri, M.P., Winarno, J., Lubis, I., Suparmanto, S., Sumardiati, A., Laras, K., Tan, R., Master, J., Warner, G., Wignall, F.S., Graham, R., Hyams, K.C. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  14. Immunohistochemistry for the detection of swine hepatitis E virus in the liver. Ha, S.K., Chae, C. J. Viral Hepat. (2004) [Pubmed]
  15. Characterization of hepatitis E virus (HEV) from Algeria and Chad by partial genome sequence. van Cuyck-Gandré, H., Zhang, H.Y., Tsarev, S.A., Clements, N.J., Cohen, S.J., Caudill, J.D., Buisson, Y., Coursaget, P., Warren, R.L., Longer, C.F. J. Med. Virol. (1997) [Pubmed]
  16. Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad. Nicand, E., Armstrong, G.L., Enouf, V., Guthmann, J.P., Guerin, J.P., Caron, M., Nizou, J.Y., Andraghetti, R. J. Med. Virol. (2005) [Pubmed]
  17. Serologic identification of hepatitis E virus infections in epidemic and endemic settings. Favorov, M.O., Fields, H.A., Purdy, M.A., Yashina, T.L., Aleksandrov, A.G., Alter, M.J., Yarasheva, D.M., Bradley, D.W., Margolis, H.S. J. Med. Virol. (1992) [Pubmed]
  18. Retrospective analysis of blood transfusion recipients: evidence for post-transfusion hepatitis E. Arankalle, V.A., Chobe, L.P. Vox Sang. (2000) [Pubmed]
  19. Construction of specifically targeted chimeric hepatitis E virus DNA vaccine and its efficacy assessment. Che, X.Y., Qian, Q.J., Liu, S.X., Huang, J., Qiu, Q.L., Xu, H., Wu, W.H. Di Yi Jun Yi Da Xue Xue Bao (2002) [Pubmed]
  20. Cloning, sequencing, and expression of the hepatitis E virus (HEV) nonstructural open reading frame 1 (ORF1). Ansari, I.H., Nanda, S.K., Durgapal, H., Agrawal, S., Mohanty, S.K., Gupta, D., Jameel, S., Panda, S.K. J. Med. Virol. (2000) [Pubmed]
  21. Promoter and intron-1 region polymorphisms in the IFNG gene in patients with hepatitis E. Arora, R., Saha, A., Malhotra, D., Rath, P., Kar, P., Bamezai, R. International journal of immunogenetics. (2005) [Pubmed]
  22. The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. Korkaya, H., Jameel, S., Gupta, D., Tyagi, S., Kumar, R., Zafrullah, M., Mazumdar, M., Lal, S.K., Xiaofang, L., Sehgal, D., Das, S.R., Sahal, D. J. Biol. Chem. (2001) [Pubmed]
  23. The ORF2 protein of hepatitis E virus binds the 5' region of viral RNA. Surjit, M., Jameel, S., Lal, S.K. J. Virol. (2004) [Pubmed]
  24. The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a kunitz-type serine protease inhibitor. Tyagi, S., Surjit, M., Lal, S.K. J. Virol. (2005) [Pubmed]
  25. Purification of a baculovirus-expressed hepatitis E virus structural protein and utility in an enzyme-linked immunosorbent assay. He, J., Ching, W.M., Yarbough, P., Wang, H., Carl, M. J. Clin. Microbiol. (1995) [Pubmed]
  26. Development of nested RT-PCR for the detection of swine hepatitis E virus in formalin-fixed, paraffin-embedded tissues and comparison with in situ hybridization. Choi, C., Ha, S.K., Chae, C. J. Virol. Methods (2004) [Pubmed]
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