Disease relevance of Andropause

• These data might have implications on the use of androgen blockade for prostate cancer prevention and androgen therapy for andropause treatment in elderly men [1].
• Age-related decline in serum testosterone level may present as a constellation of signs and symptoms of hypogonadism known as andropause [2].
• The etiopathology of age-related bone loss is multifactorial including menopause, andropause, somatopause and secondary hyperparathyroidism [3].
• Hypogonadism associated with aging (andropause) may present a mixed picture, with low testosterone levels and low to low-normal gonadotropin levels [4].

Psychiatry related information on Andropause

• As such the aging process of andropause, which is associated with declines in testosterone levels, would lead to memory loss [5].
• The andropause and memory loss: is there a link between androgen decline and dementia in the aging male [6]?

High impact information on Andropause

• Chemical andropause and amyloid-beta peptide [7].
• Andropause: is androgen replacement therapy indicated for the aging male [8]?
• After menopause or andropause, IL-6 levels are elevated, even in the absence of infection, trauma, or stress [9].
• These results suggest the marked increases in serum LH following menopause/andropause as a physiologically relevant signal that could promote Abeta secretion and deposition in the aging brain [10].
• Ninety-nine men (age 58 +/- 7 years) were considered andropausal (i.e., serum testosterone <9.8 nmol/l or luteinizing hormone [LH] >6.0 U/l and testosterone in the normal range), and in both situations, they had subjective symptoms of andropause (a high symptom score in questionnaire) [11].

Biological context of Andropause

• Climacteric medicine: European Menopause and Andropause Society (EMAS) 2004/2005 position statements on peri- and postmenopausal hormone replacement therapy [12].
• A few studies on andropause included sexual dysfunction, hormonal changes, medical/psychological correlates of impotence, ostenopenia/osteoporosis and bone loss; indices of bone remodeling, testosterone supplementation, androgen, negative feedback and hypothalamo-pituitary-testicular axis [13].

Associations of Andropause with chemical compounds

• METHOD: A MEDLINE search was conducted in which the search terms "male climacteric," "male menopause," "andropause," "viropause," "low-testosterone syndrome," and "testosterone replacement therapy" were used [14].
• Should the nonaromatizable androgen dihydrotestosterone be considered as an alternative to testosterone in the treatment of the andropause [15]?
• After menopause or andropause, loss of the normally inhibiting sex steroids (estrogen, testosterone) results in elevated IL6 levels that are further progressively increasing with age [16].
• Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse [17].
• We propose that the increase in gonadotropin concentrations, and not the decrease in steroid hormone (e.g., estrogen) production following menopause/andropause, is a potentially primary causative factor for the development of AD [18].

Gene context of Andropause

• Therefore, it is not surprising that the dysregulation of the HPG axis with menopause and andropause (leading to elevated LH, GnRH, and activin signaling but decreased sex steroid signaling) might promote alterations in both the structure and function of neuronal cells [19].
• The controversies in evaluating gonadal function are illustrated by the andropause (elevated SHBG) and obese men (decreased SHBG) [20].
• No major month to month variation in free testosterone levels in aging males. Minor impact on the biological diagnosis of 'andropause' [21].
• The role of nuclear transcription factors (androgen receptor and any other transacting factor(s) which may be involved) in the coordinate regulation of alpha 2u-globulin and SMP-2 during aging and nutritional manipulation is being explored to establish the molecular mechanism of andropause in the liver [22].
• ADAM and the andropause [23].

References