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Gene Review

LOC259246  -  alpha-2u globulin PGCL1

Rattus norvegicus

Synonyms: Allergen Rat n I, Alpha(2)-euglobulin, Alpha-2u-globulin, MUP, Major urinary protein
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Disease relevance of LOC259246

  • Concurrently the acute phase response depresses the hepatic synthesis of albumin and alpha 2u-globulin and their mRNA levels [1].
  • The toxicity is characterized by an increase in protein droplets in proximal convoluted tubular cells and an increase in the renal concentration of the male-rat-specific protein alpha 2u-globulin [2].
  • These data suggest that neonatal androgenization directly or indirectly influences the availability for transcription and/or the transcription rate of alpha 2u-globulin genes in the liver [3].

High impact information on LOC259246


Chemical compound and disease context of LOC259246


Biological context of LOC259246


Anatomical context of LOC259246


Associations of LOC259246 with chemical compounds

  • The present transcriptional studies also demonstrate that administration of dexamethasone to adrenalectomized rats dramatically elevates the rate of transcription of the alpha 1-acid glycoprotein gene as well as the alpha 2u-globulin and the albumin genes, leading to elevations in alpha 1-acid glycoprotein and alpha 2u-globulin hepatic mRNA levels [1].
  • Present transcriptional studies in isolated liver nuclei demonstrate that turpentine-induced acute phase mediators simultaneously enhance transcription of the alpha 1-acid glycoprotein gene and diminish transcription of albumin and alpha 2u-globulin genes; parallel alterations in the hepatic level of the corresponding mRNAs ensue [1].
  • Crystals of the mouse major urinary protein (MUP) and rat alpha-2u globulin (AMG) have been grown from solutions of polyethylene glycol 3350 and CdCl2, respectively [13].
  • Partial reversal of alpha 2u globulin gene expression by thyroxine in the liver of diabetic rats [14].
  • The addition of 5 alpha-dihydrotestosterone to the medium perfused through livers from castrated rats resulted in a rapid increase (approximately 10-fold over the vehicle control within 120 min) in the circulating level of alpha 2u globulin [15].

Physical interactions of LOC259246


Other interactions of LOC259246

  • Amino-acid compositional and sequence analyses as well as mass spectrometric determinations of purified rat urine proteins, previously termed prealbumin and alpha(2)-euglobulin, have revealed a high homology between the two forms which have now been identified as alpha(2)-globulin species [11].
  • On the basis of its immunochemical reactivity, SMP-3 (Mr = 19,500) is identified as alpha 2u-globulin while the mRNAs for SMP-1 (Mr = 28,500) and SMP-2 (Mr = 26,300) code for two yet uncharacterized proteins [17].
  • However, liver-specific mRNAs such as albumin and apoprotein A-1 mRNA were expressed in normal liver and PH, but to a much lesser extent in AH60C. alpha-Fetoprotein was expressed in PH, but little in the normal liver and, if any, very little in AH60C. alpha 2u-Globulin was not expressed in either AH60C or PH [18].
  • The mRNA transcript for alpha 2u-globulin declines between maturity and old age, whereas the beta-actin mRNA level remains unchanged [19].
  • The weights of testes and accessory sex organs were also reinstated after supplementation with thyroxine or alpha 2u-globulin in thyroidectomized rats in comparison with thyroidectomized animals [20].

Analytical, diagnostic and therapeutic context of LOC259246


  1. Acute phase mediators and glucocorticoids elevate alpha 1-acid glycoprotein gene transcription. Kulkarni, A.B., Reinke, R., Feigelson, P. J. Biol. Chem. (1985) [Pubmed]
  2. 2,2,4-Trimethylpentane-induced nephrotoxicity. II. The reversible binding of a TMP metabolite to a renal protein fraction containing alpha 2u-globulin. Lock, E.A., Charbonneau, M., Strasser, J., Swenberg, J.A., Bus, J.S. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  3. Influence of neonatal androgenization on the expression of alpha 2u-globulin in rat liver and submaxillary gland. Mertens, B., Verhoeven, G. J. Steroid Biochem. (1985) [Pubmed]
  4. Androgen regulated expression of the alpha 2u-globulin gene in pancreatic hepatocytes of rat. Dwivedi, R.S., Yeldandi, A.V., Subbarao, V., Feigelson, P., Roy, A.K., Reddy, J.K., Rao, M.S. J. Cell Biol. (1990) [Pubmed]
  5. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. Dunn, W.A. J. Cell Biol. (1990) [Pubmed]
  6. Cloning and sequence of several alpha 2u-globulin cDNAs. Unterman, R.D., Lynch, K.R., Nakhasi, H.L., Dolan, K.P., Hamilton, J.W., Cohn, D.V., Feigelson, P. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  7. Androgenic regulation of hepatic gene expression. Roy, A.K., Chatterjee, B., Rao, K.V., Murty, C.V., Sarkar, F.H., Majumdar, D. J. Steroid Biochem. (1987) [Pubmed]
  8. Length polymorphism in the 3' noncoding region of rat hepatic alpha 2u-globulin mRNAs. Ichiyoshi, Y., Endo, H., Yamamoto, M. Biochim. Biophys. Acta (1987) [Pubmed]
  9. Differential regulation of alpha 2u globulin gene expression in liver, lachrymal gland, and salivary gland. Gubits, R.M., Lynch, K.R., Kulkarni, A.B., Dolan, K.P., Gresik, E.W., Hollander, P., Feigelson, P. J. Biol. Chem. (1984) [Pubmed]
  10. Localization of the response elements of a gene induced by intermittent growth hormone stimulation. Johnson, D., Harrison, S., Pineda, N., Heinlein, C., al-Shawi, R., Bishop, J.O. J. Mol. Endocrinol. (1995) [Pubmed]
  11. Purification and identification of allergenic alpha (2u)-globulin species of rat urine. Bayard, C., Holmquist, L., Vesterberg, O. Biochim. Biophys. Acta (1996) [Pubmed]
  12. 2-sec-butyl-4,5-dihydrothiazole is a ligand for mouse urinary protein and rat alpha 2u-globulin: physiological and toxicological relevance. Lehman-McKeeman, L.D., Caudill, D., Rodriguez, P.A., Eddy, C. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  13. Crystallization of and preliminary X-ray data for the mouse major urinary protein and rat alpha-2u globulin. Böcskei, Z., Findlay, J.B., North, A.C., Phillips, S.E., Somers, W.S., Wright, C.E., Lionetti, C., Tirindelli, R., Cavaggioni, A. J. Mol. Biol. (1991) [Pubmed]
  14. Partial reversal of alpha 2u globulin gene expression by thyroxine in the liver of diabetic rats. Murty, C.V., Demyan, W.F., Chatterjee, B., Roy, A.K. Biochemistry (1986) [Pubmed]
  15. Rapid androgenic stimulation of alpha 2u-globulin synthesis in the perfused rat liver. Murty, C.V., Rao, K.V., Roy, A.K. Endocrinology (1987) [Pubmed]
  16. Interaction of estrogen receptor complexes with the promoter region of genes that are negatively regulated by estrogens: the alpha 2u-globulins. Van Dijck, P., Verhoeven, G. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  17. Differential regulation of the messenger RNA for three major senescence marker proteins in male rat liver. Chatterjee, B., Nath, T.S., Roy, A.K. J. Biol. Chem. (1981) [Pubmed]
  18. Difference in gene expression between azo-dye-induced primary hepatomas and corresponding transplantable ascites hepatoma lines in rats. Kohnoe, S., Maehara, Y., Endo, H. Oncology (1988) [Pubmed]
  19. Aging effects on hepatic NADPH cytochrome P450 reductase, CYP2B1&2, and polymeric immunoglobulin receptor mRNAs in male Fischer 344 rats. van Bezooijen, R.L., Wang, R.K., Lechner, M.C., Schmucker, D.L. Exp. Gerontol. (1994) [Pubmed]
  20. Effect of thyroidectomy, and thyroxine and alpha 2u-globulin replacement therapy on testicular steroidogenic and gametogenic activities in rats. Biswas, N.M., Ghosh, P.K., Biswas, R., Ghosh, D. J. Endocrinol. (1994) [Pubmed]
  21. d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and alpha 2u-globulin. Lehman-McKeeman, L.D., Rodriguez, P.A., Takigiku, R., Caudill, D., Fey, M.L. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
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