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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Hyperparathyroidism, Primary

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Disease relevance of Hyperparathyroidism, Primary


High impact information on Hyperparathyroidism, Primary

  • MATERIALS AND METHODS: We evaluated gastrin, PTH, and calcitonin responses to oral calcium (1 g) and peptones (10 g) in 10 patients with HH (mean age, 58.5 +/- 10.3 years; F/M = 9/1), 15 patients with primary hyperparathyroidism (PH; mean age, 60.4 +/- 8.3 years; F/M = 11/4), and 30 healthy controls (mean age, 60.3 +/- 8.1 years) [6].
  • However, there is evidence that continuous exposure to PTH may have an anabolic effect, for example, in patients with mild primary hyperparathyroidism (PHPT) [7].
  • We investigated the involvement of the HRPT2 gene by loss of heterozygosity analysis and direct sequencing in a kindred with hyperparathyroidism-jaw tumor syndrome (HPT-JT) and three kindreds with familial isolated primary hyperparathyroidism (FIHP) [8].
  • Increased prevalence of the polymorphic vitamin D receptor (VDR) alleles b, a, and T has been reported in sporadic primary hyperparathyroidism (PHPT), suggesting that these genetic variants may predispose to the disease [9].
  • Urinary concentrations of the collagen cross-links, pyridinoline (PYD) and deoxypyridinoline (DPD), were determined in 87 patients with untreated or surgically treated primary hyperparathyroidism (PHPT) [10].

Chemical compound and disease context of Hyperparathyroidism, Primary


Biological context of Hyperparathyroidism, Primary


Gene context of Hyperparathyroidism, Primary


Analytical, diagnostic and therapeutic context of Hyperparathyroidism, Primary


  1. Role of cyclase activating parathyroid hormone (1-84 PTH) measurements during parathyroid surgery: potential improvement of intraoperative PTH assay. Yamashita, H., Gao, P., Noguchi, S., Cantor, T., Uchino, S., Watanabe, S., Yamashita, H., Kawamoto, H., Fukagawa, M. Ann. Surg. (2002) [Pubmed]
  2. Prevalence and causes of hypergastrinemia in primary hyperparathyroidism: a prospective study. Corleto, V.D., Minisola, S., Moretti, A., Damiani, C., Grossi, C., Ciardi, S., D'Ambra, G., Bordi, C., Strom, R., Spagna, G., Delle Fave, G., Annibale, B. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  3. Expression of menin in parathyroid tumors. Bhuiyan, M.M., Sato, M., Murao, K., Imachi, H., Namihira, H., Takahara, J. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  4. Failure of cimetidine to reduce postoperative hypocalcemia in patients with primary hyperparathyroidism undergoing neck exploratory operation. Merenich, J.A., Georgitis, W.J., Clark, J.R. Surgery (1993) [Pubmed]
  5. Genetic analyses in familial isolated hyperparathyroidism: implication for clinical assessment and surgical management. Cetani, F., Pardi, E., Ambrogini, E., Lemmi, M., Borsari, S., Cianferotti, L., Vignali, E., Viacava, P., Berti, P., Mariotti, S., Pinchera, A., Marcocci, C. Clin. Endocrinol. (Oxf) (2006) [Pubmed]
  6. Dissimilar PTH, gastrin, and calcitonin responses to oral calcium and peptones in hypocalciuric hypercalcemia, primary hyperparathyroidism, and normal subjects: a useful tool for differential diagnosis. Bevilacqua, M., Dominguez, L.J., Righini, V., Valdes, V., Vago, T., Leopaldi, E., Baldi, G., Barrella, M., Barbagallo, M. J. Bone Miner. Res. (2006) [Pubmed]
  7. Continuous parathyroid hormone and estrogen administration increases vertebral cancellous bone volume and cortical width in the estrogen-deficient rat. Zhou, H., Shen, V., Dempster, D.W., Lindsay, R. J. Bone Miner. Res. (2001) [Pubmed]
  8. Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors. Cetani, F., Pardi, E., Borsari, S., Viacava, P., Dipollina, G., Cianferotti, L., Ambrogini, E., Gazzerro, E., Colussi, G., Berti, P., Miccoli, P., Pinchera, A., Marcocci, C. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  9. The vitamin D receptor (VDR) start codon polymorphism in primary hyperparathyroidism and parathyroid VDR messenger ribonucleic acid levels. Correa, P., Rastad, J., Schwarz, P., Westin, G., Kindmark, A., Lundgren, E., Akerström, G., Carling, T. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  10. Urinary hydroxypyridinium cross-links of collagen in primary hyperparathyroidism. Seibel, M.J., Gartenberg, F., Silverberg, S.J., Ratcliffe, A., Robins, S.P., Bilezikian, J.P. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  11. Serum thyroid hormone indexes in patients with primary hyperparathyroidism. Kaptein, E.M., Massry, S.G., Quion-Verde, H., Singer, F.R., Feinstein, E.I., Nicoloff, J.T., Sharp, C.F. Arch. Intern. Med. (1984) [Pubmed]
  12. Parathyroid hormone secretion: effect of beta-adrenergic blockade before and after surgery for primary hyperparathyroidism. Vora, N.M., Kukreja, S.C., Williams, G.A., Hargis, G.K. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  13. The histomorphometry of bone in primary hyperparathyroidism: preservation of cancellous bone structure. Parisien, M., Silverberg, S.J., Shane, E., de la Cruz, L., Lindsay, R., Bilezikian, J.P., Dempster, D.W. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  14. Renal calcium handling in familial hypocalciuric hypercalcemia. Watanabe, H., Sutton, R.A. Kidney Int. (1983) [Pubmed]
  15. Hypercalciuria in parathyroid disorders: effect of dietary sodium control. Muldowney, F.P., Freaney, R., Muldowney, W.P., Murray, F. Am. J. Kidney Dis. (1991) [Pubmed]
  16. Prevalence of multiple endocrine neoplasia type 1 in young patients with apparently sporadic primary hyperparathyroidism or pancreaticoduodenal endocrine tumours. Langer, P., Wild, A., Hall, A., Celik, I., Rothmund, M., Bartsch, D.K. The British journal of surgery. (2003) [Pubmed]
  17. Increase of bioavailable testosterone is associated with gain in bone mineral density after cure of primary hyperparathyroidism in postmenopausal women. Almqvist, E.G., Becker, C., Bondeson, A.G., Bondeson, L., Svensson, J. Clin. Endocrinol. (Oxf) (2006) [Pubmed]
  18. Genetic analysis of the MEN1 gene and HPRT2 locus in two Italian kindreds with familial isolated hyperparathyroidism. Cetani, F., Pardi, E., Giovannetti, A., Vignali, E., Borsari, S., Golia, F., Cianferotti, L., Viacava, P., Miccoli, P., Gasperi, M., Pinchera, A., Marcocci, C. Clin. Endocrinol. (Oxf) (2002) [Pubmed]
  19. Vitamin D receptor genotype is associated with cortical bone loss in Japanese patients with primary hyperparathyroidism. Kobayashi, T., Sugimoto, T., Kobayashi, A., Chihara, K. Endocr. J. (1998) [Pubmed]
  20. Primary hyperparathyroidism in infants. Diagnostic and therapeutic difficulties. Kulczycka, H., Kamiński, W., Woźniewicz, B., Pronicka, E. Klinische Pädiatrie. (1991) [Pubmed]
  21. Vitamin D receptor (VDR) and parathyroid hormone messenger ribonucleic acid levels correspond to polymorphic VDR alleles in human parathyroid tumors. Carling, T., Rastad, J., Akerström, G., Westin, G. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  22. Familial isolated primary hyperparathyroidism--a multiple endocrine neoplasia type 1 variant? Miedlich, S., Lohmann, T., Schneyer, U., Lamesch, P., Paschke, R. Eur. J. Endocrinol. (2001) [Pubmed]
  23. Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism. Yamashita, H., Yamashita, T., Miyamoto, M., Shigematsu, T., Kazama, J.J., Shimada, T., Yamazaki, Y., Fukumoto, S., Fukagaw, M., Noguchi, S. Eur. J. Endocrinol. (2004) [Pubmed]
  24. Clinical and laboratory features of calcium-sensing receptor disorders: a systematic review. Gunn, I.R., Gaffney, D. Ann. Clin. Biochem. (2004) [Pubmed]
  25. Association between parathyroid hormone (PTH)/PTH-related peptide receptor gene polymorphism and the extent of bone mass reduction in primary hyperparathyroidism. Kanzawa, M., Sugimoto, T., Kobayashi, T., Kobayashi, A., Chihara, K. Horm. Metab. Res. (2000) [Pubmed]
  26. Immunoreactivity of plasma parathyrin-related peptide: three region-specific radioimmunoassays and a two-site immunoradiometric assay compared. Ratcliffe, W.A., Norbury, S., Stott, R.A., Heath, D.A., Ratcliffe, J.G. Clin. Chem. (1991) [Pubmed]
  27. Minimally invasive parathyroid surgery in 103 patients with local/regional anesthesia, without exclusion criteria. Monchik, J.M., Barellini, L., Langer, P., Kahya, A. Surgery (2002) [Pubmed]
  28. Comparison of results of hormonal analysis of samples obtained from selected venous sites versus cervical ultrasonography for localizing parathyroid masses in dogs. Feldman, E.C., Wisner, E.R., Nelson, R.W., Feldman, M.S., Kennedy, P.C. J. Am. Vet. Med. Assoc. (1997) [Pubmed]
  29. Pretreatment clinical and laboratory findings in dogs with primary hyperparathyroidism: 210 cases (1987-2004). Feldman, E.C., Hoar, B., Pollard, R., Nelson, R.W. J. Am. Vet. Med. Assoc. (2005) [Pubmed]
  30. Parathyroid hormone immunohistochemistry in dogs with primary and secondary hyperparathyroidism: the question of adenoma and primary hyperplasia. van Vonderen, I.K., Kooistra, H.S., Peeters, M.E., Rijnberk, A., van den Ingh, T.S. J. Comp. Pathol. (2003) [Pubmed]
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