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MeSH Review

Knowledge Bases

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Disease relevance of Knowledge Bases

  • An expanding knowledge base has substantially advanced our understanding of structure-function and genotype-phenotype relationships for voltage-gated sodium channels and provided new insights into the pathophysiological basis for common diseases such as cardiac arrhythmias and epilepsy [1].
  • Cyclophosphamide in the treatment of pulmonary diseases: survey of use, training, and practitioner knowledge base [2].
  • Our knowledge base on systemic therapy for breast cancer continues to expand, including further information regarding hormonal prevention in high-risk women, beneficial effects of tamoxifen in noninvasive disease, an update on primary systemic therapy, and optimization of adjuvant strategies, including data on adjuvant chemoendocrine regimens [3].
  • Building the knowledge base for practice, Part II: alopecia, breast self-exam and other human responses [4].

High impact information on Knowledge Bases

  • The new data extend the knowledge base for understanding the binding of gluten peptides to DQ2 [5].
  • With a growing knowledge base supporting the safety and beneficial clinical effects associated with EECP, this therapy can be considered a valuable treatment option, particularly in patients who have exhausted traditional revascularization methods and yet remain symptomatic despite optimal medical care [6].
  • Analyses of the examination scores showed that performance on the initial American Board of Internal Medicine certification examination taken 7.6 years previously was the major factor predicting current knowledge base [7].
  • The impressive and rapidly expanding knowledge base on SARS [8].
  • Successful clinical care is based on three critical elements (the "clinician's triad"): an adequate knowledge base, a positive attitude toward the patient and the benefits of treatment, and a sense of responsibility for the clinical problem [9].

Biological context of Knowledge Bases

  • These findings suggest a means to begin to construct a more comprehensive estrogen knowledge base by combining RBA assay data from multiple species in 3D-QSAR based predictive models, which could then be used to screen untested chemicals for their potential to bind to the ER [10].
  • These databases work as the backend of NRPS-PKS and provide the knowledge base for predicting domain organization and substrate specificity of uncharacterized NRPS/PKS clusters [11].
  • ATHENA DSS has an easily modifiable knowledge base that specifies eligibility criteria, risk stratification, blood pressure targets, relevant comorbid diseases, guideline-recommended drug classes for patients with comorbid disease, preferred drugs within each drug class, and clinical messages [12].

Anatomical context of Knowledge Bases

  • Database model and specification of GermOnline Release 2.0, a cross-species community annotation knowledgebase on germ cell differentiation [13].
  • Dialysis emerged from the development of six distinct scientific and medical knowledge bases: 1) mechanical forces (diffusion and convection); 2) anticoagulants (hirudin and heparin); 3) membranes (collodion and cellophane); 4) kidney physiology; 5) serum and urine analysis; and 6) clinical perceptions and treatment [14].
  • This paper will review the current literature addressing hepatic effects of GLP-1 and identify important gaps in the knowledge base for this topic [15].
  • These developments in understanding MS are complemented by advances in clarifying the molecular mechanisms of leukocyte extravasation and providing the knowledge base needed to modulate tissue inflammation [16].

Associations of Knowledge Bases with chemical compounds

  • Overall, these new techniques have resulted in a number of novel antipsychotics such as risperidone, sertindole, olanzapine, seroquel, zotepine and ziprasidone, whose design, synthesis and testing has benefited enormously from the accumulated knowledge base of the past 50 years [17].
  • This review concentrates on recent work on the role of melatonin in the regulation of porcine reproduction, cervine endocrine, and behavioral cycles and wool and cashmere production which has added to this knowledge base [18].
  • A weight-of-evidence review of the entire scientific knowledge base relating to chlorpyrifos products supports these conclusions [19].
  • In each case, there have been clinically significant advances in the knowledge base over recent years, notably in the understanding of steroidogenesis, cortisol action, and metabolism [20].
  • This analysis used five chemical databases, CMC and MDDR, which represent knowledge bases containing active medicinal agents, ACD and SPECS, two databases of commercially available compounds, and finally the Wellcome Registry [21].

Gene context of Knowledge Bases

  • Thus our results extend the knowledge base of residues involved in NMDA receptor function and identifies a new site in S1, in the region of A508, that has a role in receptor activation by glutamate [22].
  • This database provides insights into the molecular aspects and clinical significance of G6PD deficiency for researchers and clinicians and the web page functions as a knowledge base relevant to the understanding of G6PD deficiency and its management [23].
  • For many agents, the CYP isoform involved in metabolism has not been identified and there is substantial uncertainty given the current knowledge base [24].
  • The knowledge base constructed for PROSP contains small peptides together with their secondary structural information [25].
  • One objective of this study was to determine if the accumulation of MT protein in cultures of human proximal tubule (HPT) cells exposed to metals is similar to that expected from the knowledge base obtained from rodent models [26].

Analytical, diagnostic and therapeutic context of Knowledge Bases


  1. Inherited disorders of voltage-gated sodium channels. George, A.L. J. Clin. Invest. (2005) [Pubmed]
  2. Cyclophosphamide in the treatment of pulmonary diseases: survey of use, training, and practitioner knowledge base. Cozzi, P.J., Hall, J.B. Chest (1999) [Pubmed]
  3. Systemic therapy. Wolff, A.C. Current opinion in oncology. (2000) [Pubmed]
  4. Building the knowledge base for practice, Part II: alopecia, breast self-exam and other human responses. Lindsey, A.M. Oncology nursing forum. (1985) [Pubmed]
  5. Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation. Qiao, S.W., Bergseng, E., Molberg, O., Jung, G., Fleckenstein, B., Sollid, L.M. J. Immunol. (2005) [Pubmed]
  6. Enhanced external counterpulsation for ischemic heart disease: what's behind the curtain? Bonetti, P.O., Holmes, D.R., Lerman, A., Barsness, G.W. J. Am. Coll. Cardiol. (2003) [Pubmed]
  7. The knowledge base of certified internists. Relationships to training, practice type, and other physician characteristics. Carline, J.D., Inui, T.S., Larson, E.B., LoGerfo, J.P., Ramsey, P.G. Arch. Intern. Med. (1989) [Pubmed]
  8. The impressive and rapidly expanding knowledge base on SARS. Hughes, J.M. Emerging Infect. Dis. (2004) [Pubmed]
  9. How to train residents to identify and treat dual diagnosis patients. Renner, J.A. Biol. Psychiatry (2004) [Pubmed]
  10. Quantitative structure-activity relationships (QSARs) for estrogen binding to the estrogen receptor: predictions across species. Tong, W., Perkins, R., Strelitz, R., Collantes, E.R., Keenan, S., Welsh, W.J., Branham, W.S., Sheehan, D.M. Environ. Health Perspect. (1997) [Pubmed]
  11. NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases. Ansari, M.Z., Yadav, G., Gokhale, R.S., Mohanty, D. Nucleic Acids Res. (2004) [Pubmed]
  12. Implementing clinical practice guidelines while taking account of changing evidence: ATHENA DSS, an easily modifiable decision-support system for managing hypertension in primary care. Goldstein, M.K., Hoffman, B.B., Coleman, R.W., Musen, M.A., Tu, S.W., Advani, A., Shankar, R., O'Connor, M. Proceedings / AMIA ... Annual Symposium. AMIA Symposium. (2000) [Pubmed]
  13. Database model and specification of GermOnline Release 2.0, a cross-species community annotation knowledgebase on germ cell differentiation. Wiederkehr, C., Basavaraj, R., Sarrauste de Menthière, C., Koch, R., Schlecht, U., Hermida, L., Masdoua, B., Ishii, R., Cassen, V., Yamamoto, M., Lane, C., Cherry, M., Lamb, N., Primig, M. Bioinformatics (2004) [Pubmed]
  14. Hemodialysis 1912-1945: no medical technology before its time: part II. Fagette, P. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1999) [Pubmed]
  15. Effects of glucagon-like peptide 1 on the hepatic glucose metabolism. D'Alessio, D., Vahl, T., Prigeon, R. Horm. Metab. Res. (2004) [Pubmed]
  16. Chemokine receptor antagonism as a new therapy for multiple sclerosis. Ransohoff, R.M., Bacon, K.B. Expert opinion on investigational drugs. (2000) [Pubmed]
  17. Schizophrenia: genesis, receptorology and current therapeutics. Capuano, B., Crosby, I.T., Lloyd, E.J. Current medicinal chemistry. (2002) [Pubmed]
  18. Melatonin and farm animals: endogenous rhythms and exogenous applications. Paterson, A.M., Foldes, A. J. Pineal Res. (1994) [Pubmed]
  19. Human exposure and risk from indoor use of chlorpyrifos. Gibson, J.E., Peterson, R.K., Shurdut, B.A. Environ. Health Perspect. (1998) [Pubmed]
  20. Adrenal corticosteroid biosynthesis, metabolism, and action. Arlt, W., Stewart, P.M. Endocrinol. Metab. Clin. North Am. (2005) [Pubmed]
  21. Molecular diversity in chemical databases: comparison of medicinal chemistry knowledge bases and databases of commercially available compounds. Cummins, D.J., Andrews, C.W., Bentley, J.A., Cory, M. Journal of chemical information and computer sciences. (1996) [Pubmed]
  22. Identification of a new site in the S1 ligand binding region of the NMDA receptor NR2A subunit involved in receptor activation by glutamate. Lummis, S.C., Fletcher, E.J., Green, T. Neuropharmacology (2002) [Pubmed]
  23. G6PDdb, an integrated database of glucose-6-phosphate dehydrogenase (G6PD) mutations. Kwok, C.J., Martin, A.C., Au, S.W., Lam, V.M. Hum. Mutat. (2002) [Pubmed]
  24. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Bertz, R.J., Granneman, G.R. Clinical pharmacokinetics. (1997) [Pubmed]
  25. HYPROSP II--a knowledge-based hybrid method for protein secondary structure prediction based on local prediction confidence. Lin, H.N., Chang, J.M., Wu, K.P., Sung, T.Y., Hsu, W.L. Bioinformatics (2005) [Pubmed]
  26. Exposure of human proximal tubule cells to cd2+, zn2+, and Cu2+ induces metallothionein protein accumulation but not metallothionein isoform 2 mRNA. Garrett, S.H., Somji, S., Todd, J.H., Sens, D.A. Environ. Health Perspect. (1998) [Pubmed]
  27. A computer-assisted drug prescription system: the model and its implementation in the ATM knowledge base. Riou, C., Pouliquen, B., Le Beux, P. Methods of information in medicine. (1999) [Pubmed]
  28. A java-based application for differential diagnosis of hematopoietic neoplasms using immunophenotyping by flow cytometry. Nguyen, A.N., Milam, J.D., Johnson, K.A., Banez, E.I. Comput. Biol. Med. (2000) [Pubmed]
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