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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Marezine     1-benzhydryl-4-methyl- piperazine

Synonyms: Wellcome, CYCLIZINE, Ciclizina, Emoquil, Marzine, ...
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Disease relevance of CYCLIZINE


Psychiatry related information on CYCLIZINE


High impact information on CYCLIZINE


Chemical compound and disease context of CYCLIZINE


Biological context of CYCLIZINE

  • Wellcome Trust loses battle to expand its genome campus [21].
  • PURPOSE: The feasibility of administering vinorelbine (Navelbine, Burroughs Wellcome Co, Research Triangle Park, NC), a semisynthetic vinca alkaloid with broad activity, as a liquid-filled gelatin capsule was evaluated in a bioavailability (F) and pharmacokinetic study [22].
  • Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22 [23].
  • We present a region template and a protocol for transforming that template to define anatomical volumes of interest (VOIs) in the human brain without operator intervention, based on software contained in the SPM99 package (Statistical Parametric Mapping, Wellcome Department of Cognitive Neurology, London, UK) [24].
  • Using enzyme-linked immunosorbent assay, we measured antibody responses to recombinant gluthathione S-transferase-PfMSP119 fusion proteins corresponding to the Wellcome and MAD20 allelic variants in these samples [25].

Anatomical context of CYCLIZINE

  • PGI2 sodium salt (Epoprostenol, Wellcome Research Laboratories and Upjohn Company) or its solvent (glycine buffer) were infused into the subclavian vein for six-hour periods in five courses separated by six-hour intervals [26].
  • Previous studies in our laboratory demonstrated that the synthetic surfactant Exosurf (Burroughs Wellcome Co.) inhibited endotoxin-stimulated cytokine secretion from human alveolar macrophages in vitro [27].
  • Campath-1H (Wellcome, Beckenham, UK, and Ilex Oncology, San Antonio, TX), an anti-CD52 monoclonal antibody, has demonstrated significant activity in patients with previously untreated, relapsed, or refractory chronic lymphocytic leukemia (CLL), as well as in patients with T-cell prolymphocytic leukemia [28].
  • The Wellcogen Strep B latex agglutination test (Wellcome Diagnostics, Dartford, England) was evaluated as a method of detecting group B streptococcal antigen in urine, cerebrospinal fluid, and serum from neonates with early-onset (less than or equal to 7 days of age) and late-onset group B streptococcal disease [29].
  • The semisynthetic vinca alkaloid vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre Médicament, Paris, France) is unique in its chemical structure, microtubule selectivity, and neurotoxicity profile [30].

Associations of CYCLIZINE with other chemical compounds


Gene context of CYCLIZINE

  • Recently, Burroughs Wellcome disclosed a series of cyclic peptides, including the compound 1229U91, which were reported to be selective NPY receptor antagonists (PCT Publication No. WO 94/00486) [36].
  • The performance and clinical utility of a 'C-terminal' parathyroid hormone (PTH) radioimmunoassay (Dac-Cel, Wellcome Diagnostics) is described [37].
  • Considerable overlapping of individual TBPA values were found between normals and undernourished in Wellcome classification but very little overlapping was found between normals and mild PEM in Waterlow's classification [38].
  • Sera from almost all donors contained antibodies to the 33-kDa processing product of the MAD20 allele of MSP-1 (MSP-1(33)), but these antibodies did not cross-react with the equivalent sequence of the Wellcome allele [39].
  • The effect of valaciclovir on cytomegalovirus viremia and viruria detected by polymerase chain reaction in patients with advanced human immunodeficiency virus disease. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study Group [40].

Analytical, diagnostic and therapeutic context of CYCLIZINE


  1. Mismatched double-stranded RNA (ampligen) reduces concentration of zidovudine (azidothymidine) required for in-vitro inhibition of human immunodeficiency virus. Mitchell, W.M., Montefiori, D.C., Robinson, W.E., Strayer, D.R., Carter, W.A. Lancet (1987) [Pubmed]
  2. A randomized comparison of two doses of human lymphoblastoid interferon-alpha in hairy cell leukemia. Wellcome HCL Study Group. Smalley, R.V., Anderson, S.A., Tuttle, R.L., Connors, J., Thurmond, L.M., Huang, A., Castle, K., Magers, C., Whisnant, J.K. Blood (1991) [Pubmed]
  3. Treatment of acquired immunodeficiency syndrome--related Kaposi's sarcoma with lymphoblastoid interferon. Rios, A., Mansell, P.W., Newell, G.R., Reuben, J.M., Hersh, E.M., Gutterman, J.U. J. Clin. Oncol. (1985) [Pubmed]
  4. Wellcome Filariasis seminar '85. Goodwin, L.G. Parasitol. Today (Regul. Ed.) (1986) [Pubmed]
  5. The pattern of severe protein-calorie malnutrition in Sudanese children attending a large hospital in The Sudan. Taha, S.A. Am. J. Clin. Nutr. (1979) [Pubmed]
  6. The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. Bennett, P., Segurado, R., Jones, I., Bort, S., McCandless, F., Lambert, D., Heron, J., Comerford, C., Middle, F., Corvin, A., Pelios, G., Kirov, G., Larsen, B., Mulcahy, T., Williams, N., O'Connell, R., O'Mahony, E., Payne, A., Owen, M., Holmans, P., Craddock, N., Gill, M. Mol. Psychiatry (2002) [Pubmed]
  7. Voxel-based morphometry in hypocretin-deficient narcolepsy. Overeem, S., Steens, S.C., Good, C.D., Ferrari, M.D., Mignot, E., Frackowiak, R.S., van Buchem, M.A., Lammers, G.J. Sleep. (2003) [Pubmed]
  8. Wellcome witnesses: the Medical Research Council Applied Psychology Unit. Reynolds, L. History of psychology. (2004) [Pubmed]
  9. Sustained-release bupropion overdose: a new entity for Australian emergency departments. Paoloni, R., Szekely, I. Emergency medicine (Fremantle, W.A.) (2002) [Pubmed]
  10. Measurement of basal forebrain atrophy in Alzheimer's disease using MRI. Teipel, S.J., Flatz, W.H., Heinsen, H., Bokde, A.L., Schoenberg, S.O., Stöckel, S., Dietrich, O., Reiser, M.F., Möller, H.J., Hampel, H. Brain (2005) [Pubmed]
  11. Wellcome Trust funds bid to unravel zebrafish genome. Butler, D. Nature (2000) [Pubmed]
  12. Wellcome discusses structural genomics effort with industry...but data release remains an open question. Butler, D. Nature (2000) [Pubmed]
  13. UK biotechnology. Biotechnology no longer Wellcome. Aldhous, P. Nature (1990) [Pubmed]
  14. Biotechnology: Wellcome drops TPA. Gershon, D. Nature (1990) [Pubmed]
  15. Four-year PhDs in neuroscience: an assessment after four years. Rawlins, N., Akerman, C.J., Andolina, I., Blakemore, S.J., Mrsic-Flogel, T., Attwell, D. Trends Neurosci. (2000) [Pubmed]
  16. Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Hussein, Z., Beerahee, M., Grover, R., Jordan, B., Jeffs, R., Donaldson, J., Zaccardelli, D., Colice, G., Guntupalli, K., Watson, D., Vincent, J.L. Clin. Pharmacol. Ther. (1999) [Pubmed]
  17. Biochemical mechanisms of the antileishmanial activity of sodium stibogluconate. Berman, J.D., Waddell, D., Hanson, B.D. Antimicrob. Agents Chemother. (1985) [Pubmed]
  18. Quantitative effects of valacyclovir on the replication of cytomegalovirus (CMV) in persons with advanced human immunodeficiency virus disease: baseline CMV load dictates time to disease and survival. The AIDS Clinical Trials Group 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study Group. Emery, V.C., Sabin, C., Feinberg, J.E., Grywacz, M., Knight, S., Griffiths, P.D. J. Infect. Dis. (1999) [Pubmed]
  19. Multicenter evaluation of the novel ABN Western blot (immunoblot) system in comparison with an enzyme-linked immunosorbent assay and a different Western blot. Weber, B., Hess, G., Enzensberger, R., Harms, F., Evans, C.J., Hamann, A., Doerr, H.W. J. Clin. Microbiol. (1992) [Pubmed]
  20. Detection of bacterial antigens in body fluids with the Wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (ACYW135) latex agglutination tests. Ingram, D.L., Pearson, A.W., Occhiuti, A.R. J. Clin. Microbiol. (1983) [Pubmed]
  21. Wellcome Trust loses battle to expand its genome campus. Loder, N. Nature (1999) [Pubmed]
  22. Pharmacokinetic, bioavailability, and feasibility study of oral vinorelbine in patients with solid tumors. Rowinsky, E.K., Noe, D.A., Trump, D.L., Winer, E.P., Lucas, V.S., Wargin, W.A., Hohneker, J.A., Lubejko, B., Sartorius, S.E., Ettinger, D.S. J. Clin. Oncol. (1994) [Pubmed]
  23. Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22. Lambert, D., Middle, F., Hamshere, M.L., Segurado, R., Raybould, R., Corvin, A., Green, E., O'mahony, E., Nikolov, I., Mulcahy, T., Haque, S., Bort, S., Bennett, P., Norton, N., Owen, M.J., Kirov, G., Lendon, C., Jones, L., Jones, I., Holmans, P., Gill, M., Craddock, N. Mol. Psychiatry (2006) [Pubmed]
  24. Implementation and application of a brain template for multiple volumes of interest. Hammers, A., Koepp, M.J., Free, S.L., Brett, M., Richardson, M.P., Labbé, C., Cunningham, V.J., Brooks, D.J., Duncan, J. Human brain mapping. (2002) [Pubmed]
  25. Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria. Dodoo, D., Theander, T.G., Kurtzhals, J.A., Koram, K., Riley, E., Akanmori, B.D., Nkrumah, F.K., Hviid, L. Infect. Immun. (1999) [Pubmed]
  26. Double-blind controlled trial of the therapeutic effects of prostacyclin in patients with completed ischaemic stroke. Huczynski, J., Kostka-Trabka, E., Sotowska, W., Bieron, K., Grodzinska, L., Dembinska-Kiec, A., Pykosz-Mazur, E., Peczak, E., Gryglewski, R.J. Stroke (1985) [Pubmed]
  27. Characterization of exosurf (surfactant)-mediated suppression of stimulated human alveolar macrophage cytokine responses. Thomassen, M.J., Antal, J.M., Connors, M.J., Meeker, D.P., Wiedemann, H.P. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  28. Monoclonal antibody therapies in leukemias. Tallman, M.S. Semin. Hematol. (2002) [Pubmed]
  29. Detection of group B streptococcal antigen in early-onset and late-onset group B streptococcal disease with the Wellcogen Strep B latex agglutination test. Ingram, D.L., Suggs, D.M., Pearson, A.W. J. Clin. Microbiol. (1982) [Pubmed]
  30. Summary of data from in vitro and phase I vinorelbine (Navelbine) studies. Burris, H.A., Fields, S. Semin. Oncol. (1994) [Pubmed]
  31. Use of monoclonal antibody to immunochemically characterize variant-specific surface coat glycoprotein from Trypanosoma rhodesiense. Lyon, J.A., Pratt, J.M., Travis, R.W., Doctor, B.P., Olenick, J.G. J. Immunol. (1981) [Pubmed]
  32. Current management of unresectable non-small cell lung cancer. Livingston, R.B. Semin. Oncol. (1994) [Pubmed]
  33. Safety review of adult clinical trial experience with lamotrigine. Messenheimer, J., Mullens, E.L., Giorgi, L., Young, F. Drug safety : an international journal of medical toxicology and drug experience. (1998) [Pubmed]
  34. Pharmacokinetics and bioequivalence of a combined oral formulation of eniluracil, an inactivator of dihydropyrimidine dehydrogenase, and 5-fluorouracil in patients with advanced solid malignancies. Ochoa, L., Hurwitz, H.I., Wilding, G., Cohen, D., Thomas, J.P., Schwartz, G., Monroe, P., Petros, W.P., Ertel, V.P., Hsieh, A., Hoffman, C., Drengler, R., Magnum, S., Rowinsky, E.K. Ann. Oncol. (2000) [Pubmed]
  35. Clinical evaluation of Abbott and Wellcome enzyme linked immunosorbent assays for detection of serum antibodies to human immunodeficiency virus (HIV). Evans, R.P., Shanson, D.C., Mortimer, P.P. J. Clin. Pathol. (1987) [Pubmed]
  36. Pharmacological evaluation of 1229U91, a novel high-affinity and selective neuropeptide Y-Y1 receptor antagonist. Hegde, S.S., Bonhaus, D.W., Stanley, W., Eglen, R.M., Moy, T.M., Loeb, M., Shetty, S.G., DeSouza, A., Krstenansky, J. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  37. Performance and clinical utility of a commercially available 'C-terminal' PTH assay. Ingle, A.R., Bailey, J.E., Matthews, H.L., Harrop, J.S. Ann. Clin. Biochem. (1986) [Pubmed]
  38. Plasma thyroxine binding prealbumin as an index of mild protein-energy malnutrition in Nigerian children. Ogunshina, S.O., Hussain, M.A. Am. J. Clin. Nutr. (1980) [Pubmed]
  39. Characterization of human T- and B-cell epitopes in the C terminus of Plasmodium falciparum merozoite surface protein 1: evidence for poor T-cell recognition of polypeptides with numerous disulfide bonds. Egan, A., Waterfall, M., Pinder, M., Holder, A., Riley, E. Infect. Immun. (1997) [Pubmed]
  40. The effect of valaciclovir on cytomegalovirus viremia and viruria detected by polymerase chain reaction in patients with advanced human immunodeficiency virus disease. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study Group. Griffiths, P.D., Feinberg, J.E., Fry, J., Sabin, C., Dix, L., Gor, D., Ansari, A., Emery, V.C. J. Infect. Dis. (1998) [Pubmed]
  41. Gene therapy coming of age in Latin America. Podhajcer, O., Pitossi, F., Agilar-Cordova, E. Mol. Ther. (2002) [Pubmed]
  42. Vinorelbine (Navelbine) in non-small cell lung cancer: future directions. Crawford, J. Semin. Oncol. (1994) [Pubmed]
  43. Vinorelbine (Navelbine) in the adjuvant and neoadjuvant treatment of non-small cell lung cancer. Viallet, J., Ayoub, J., Rousseau, P., Souhami, L., Hohneker, J., Shepherd, F. Semin. Oncol. (1994) [Pubmed]
  44. Preliminary report on a phase I study of ifosfamide and vinorelbine (navelbine) in advanced non-small cell lung cancer. Masters, G.A., Hoffman, P.C., Drinkard, L.C., Watson, S., Samuels, B.L., Golomb, H.M., Vokes, E.E. Semin. Oncol. (1996) [Pubmed]
  45. Cost-effectiveness of fluticasone propionate administered via metered-dose inhaler plus babyhaler spacer in the treatment of asthma in preschool-aged children. Bisgaard, H., Price, M.J., Maden, C., Olsen, N.A. Chest (2001) [Pubmed]
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