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MeSH Review

Reflex, Stretch

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Disease relevance of Reflex, Stretch


Psychiatry related information on Reflex, Stretch


High impact information on Reflex, Stretch

  • Stretch reflex dynamics in spastic elbow flexor muscles [5].
  • The distribution pattern of dystonia, the stretch reflex abnormalities, and the worsening of dystonia after tactile and auditory stimuli suggest impairment of interneuronal circuits at the brainstem or spinal level [6].
  • The earliest response (RP1) is assumed to be a short-latency stretch reflex evoked by the considerable impact of the collision, whereas the second (RP2) has features reminiscent of cutaneous and proprioceptive responses [7].
  • Ventral topical application of the selective 5-HT2A/2C agonist (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane hydrochloride (DOI) restored the amplitude of the MG stretch reflex in a dose-dependent fashion [8].
  • 6. Dantrolene sodium also caused a shift in the relationship between tension and integrated EMG during the phasic component of the stretch reflex, with a greater integrated EMG being associated with a reduced tension [9].

Biological context of Reflex, Stretch


Anatomical context of Reflex, Stretch

  • 4. On the hypothesis that the excess latency of the stretch reflex over that of a tendon jerk is because the stretch reflex employs a cortical rather than a spinal arc, the excess would be expected to be larger in magnitude for the long flexor of the big toe and smaller for the jaw closing muscles [11].
  • It is proposed that the impaired modulation of the stretch reflex along with increased ankle joint stiffness contribute to the impaired walking ability in spastic MS patients [12].
  • It is suggested that the absence of the long-latency stretch reflex and the delay in the response to loading in HD patients may represent a reduction in somatosensory input to the cortex caused by disruption of basal ganglia structures [13].
  • The modulation of the short latency stretch reflex of the soleus muscle during walking was investigated in seven spastic multiple sclerosis (MS) patients and nine healthy control subjects [12].
  • It was found that muscle fibers of the MG were not stretched during counter movement; therefore, stretch reflex and potentiation of the contractile component of the MG might not contribute to the work enhancement in CMJ [14].

Associations of Reflex, Stretch with chemical compounds


Gene context of Reflex, Stretch

  • Essential tremor and mechanically-induced stretch-reflex oscillations are separate phenomena capable of complex interaction [20].
  • Increasing the stretch repetition rate from 0.1 to 0.4 cycles/s did not affect the SL component of either group, whereas the LL stretch reflex was reduced in size and duration in normal controls, but not in HD patients [21].
  • The SL-response in the triceps surae muscle, which corresponds to the mono- and oligo-synaptic spinal stretch reflex, showed a decreasing latency up to the age of 5 years [22].
  • This analysis determined that for both the ACL leg and the Non ACL leg the size of stretch reflex was facilitated at the long-latency conditioning intervals (75 and 150 ms), whereas it was inhibited at the short-latency conditioning interval (25ms) [23].
  • However, the ANOVA model failed to reveal any differences in the conditioned stretch reflex between the ACL leg and the Non ACL leg [23].

Analytical, diagnostic and therapeutic context of Reflex, Stretch


  1. Baclofen increases the soleus stretch reflex threshold in the early swing phase during walking in spastic multiple sclerosis patients. Nielsen, J.F., Anderson, J.B., Sinkjaer, T. Mult. Scler. (2000) [Pubmed]
  2. Quantification of hyperreflexia in amyotrophic lateral sclerosis (ALS) by the soleus stretch reflex. Christensen, P.B., Nielsen, J.F., Sinkjaer, T. Amyotroph. Lateral Scler. Other Motor Neuron Disord. (2003) [Pubmed]
  3. Gain of the triceps surae stretch reflex in decerebrate and spinal cats during postural and locomotor activities. Bennett, D.J., De Serres, S.J., Stein, R.B. J. Physiol. (Lond.) (1996) [Pubmed]
  4. Relationship between the degree of inhibited stretch reflex activities of the wrist flexor and reaction time during quick extension movements. Kizuka, T., Asami, T., Tanii, K. Electroencephalography and clinical neurophysiology. (1997) [Pubmed]
  5. Stretch reflex dynamics in spastic elbow flexor muscles. Powers, R.K., Campbell, D.L., Rymer, W.Z. Ann. Neurol. (1989) [Pubmed]
  6. Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy. van Hilten, J.J., van de Beek, W.J., Vein, A.A., van Dijk, J.G., Middelkoop, H.A. Neurology (2001) [Pubmed]
  7. Muscular responses and movement strategies during stumbling over obstacles. Schillings, A.M., van Wezel, B.M., Mulder, T., Duysens, J. J. Neurophysiol. (2000) [Pubmed]
  8. Restoration of extensor excitability in the acute spinal cat by the 5-HT2 agonist DOI. Miller, J.F., Paul, K.D., Lee, R.H., Rymer, W.Z., Heckman, C.J. J. Neurophysiol. (1996) [Pubmed]
  9. The effect of dantrolene sodium on the discharge of alpha and gamma motoneurones to the soleus muscle in the decerebrate rat. Farquhar, R., Part, N.J. Br. J. Pharmacol. (1988) [Pubmed]
  10. Differences in stretch reflex responses of elbow flexor muscles during shortening, lengthening and isometric contractions. Nakazawa, K., Yano, H., Satoh, H., Fujisaki, I. European journal of applied physiology and occupational physiology. (1998) [Pubmed]
  11. Stretch reflex and servo action in a variety of human muscles. Marsden, C.D., Merton, P.A., Morton, H.B. J. Physiol. (Lond.) (1976) [Pubmed]
  12. Impaired stretch reflex and joint torque modulation during spastic gait in multiple sclerosis patients. Sinkjaer, T., Andersen, J.B., Nielsen, J.F. J. Neurol. (1996) [Pubmed]
  13. Disturbances of precision grip in Huntington's disease. Fellows, S., Schwarz, M., Schaffrath, C., Dömges, F., Noth, J. Neurosci. Lett. (1997) [Pubmed]
  14. Interaction between fascicles and tendinous structures during counter movement jumping investigated in vivo. Kurokawa, S., Fukunaga, T., Nagano, A., Fukashiro, S. J. Appl. Physiol. (2003) [Pubmed]
  15. The effects of baclofen on the stretch reflex parameters of the cat. Capaday, C. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1995) [Pubmed]
  16. Modulation of the tonic stretch reflex by monoamines. Commissiong, J.W., Sedgwick, E.M. Eur. J. Pharmacol. (1979) [Pubmed]
  17. Prolonged muscle vibration increases stretch reflex amplitude, motor unit discharge rate, and force fluctuations in a hand muscle. Shinohara, M., Moritz, C.T., Pascoe, M.A., Enoka, R.M. J. Appl. Physiol. (2005) [Pubmed]
  18. Enhancement by serotonin of tonic vibration and stretch reflexes in the decerebrate cat. Carp, J.S., Rymer, W.Z. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1986) [Pubmed]
  19. Glutamate evoked neck and jaw muscle pain facilitate the human jaw stretch reflex. Wang, K., Sessle, B.J., Svensson, P., Arendt-Nielsen, L. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2004) [Pubmed]
  20. Stretch reflex oscillations and essential tremor. Elble, R.J., Higgins, C., Moody, C.J. J. Neurol. Neurosurg. Psychiatr. (1987) [Pubmed]
  21. Impaired habituation of long-latency stretch reflexes of the wrist muscles in Huntington's disease. Abbruzzese, G., Dall'Agata, D., Morena, M., Spadavecchia, L., Ratto, S., Favale, E. Mov. Disord. (1990) [Pubmed]
  22. Development of postural control in children: short-, medium-, and long latency EMG responses of leg muscles after perturbation of stance. Haas, G., Diener, H.C., Bacher, M., Dichgans, J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1986) [Pubmed]
  23. Conditioned patellar tendon-tap reflexes in patients with ACL reconstruction. Tsuruike, M., Koceja, D.M. International journal of sports medicine. (1999) [Pubmed]
  24. Intact inhibition of the stretch reflex during general tetanus. Takano, K., Kirchner, F., Mizote, M. Toxicon (1991) [Pubmed]
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