Disease relevance of Rh Isoimmunization

• With amniotic fluid creatinine levels below the normal range, 3 of 6 infants had major congenital abnormalities and two had severe rhesus isoimmunization; 3 of the infants died [1].
• Amniotic fluid creatinine, percentage of lipid-positive cells, and L/S ratio were determined on 285 samples from normal pregnancies and 222 samples from abnormal pregnancy states (Rh isoimmunization, diabetes, hypertensive disorders, intrauterine growth retardation, and hydramnios) [2].
• The strikingly higher circulating PP5 levels found in all nine patients with Rh isoimmunization studied suggests that serum PP5 may be specifically elevated in pregnant patients with Rh isoimmunization and hydrops fetalis [3].
• The most common cause of hemolytic hyperbilirubinemia needing exchange blood transfusion was Rh isoimmunization followed by G-6-PD deficiency and ABO isoimmunization [4].

High impact information on Rh Isoimmunization

• This direct interference of glucocorticoids with the spectrophotometry of bilirubin in amniotic fluid prompts cautious interpretation of such data as an index to the severity of hemolytic disease of the fetus, specifically in cases of Rhesus-isoimmunization that are being treated with glucocorticoids [5].
• Because control infants (n = 13) and infants with ABO hemolytic disease (n = 5) did not differ from one another in any of the study parameters, these two groups were combined and compared with infants with the Rh isoimmunization [6].
• OBJECTIVE: To determine whether plasma erythropoietin is increased in fetuses with anemia due to Rh isoimmunization [7].
• Paired maternal and fetal atrial natriuretic peptide concentrations were measured in 62 percutaneous umbilical blood samplings performed principally for the assessment and treatment of rhesus isoimmunization [8].
• Placental transfer of cefazolin and piperacillin in pregnancies remote from term complicated by Rh isoimmunization [9].

Chemical compound and disease context of Rh Isoimmunization

• It is seen more frequently in cetain complications of pregnancy such as abrupti placentage, maternal diabetes, macerated intrauterine death and in conditions affectint the infant including prematurity, rhesus isoimmunization, respiratory distress syndrome (RDS) and transient respiratory distress (TRD) [10].
• Promethazine hydrochloride: use in patients with Rh isoimmunization [11].
• Rh isoimmunization, maternal Phenobarbital use and lack of parental consent were exclusion criteria [12].
• Hypoxanthine in fetal umbilical venous blood and amniotic fluid from pregnancies complicated by rhesus isoimmunization [13].

Gene context of Rh Isoimmunization

• Amniotic fluid insulin and glucagon in normal pregnancy and pregnancy complicated by rhesus isoimmunization [14].
• In the near future, pregnant women truly at risk for Rh isoimmunization may be identified by analysis of their blood, and this will be a rational basis for antepartum Rho (D) immune globulin (human) treatment [15].
• Plasmapheresis as therapy for Rh isoimmunization has gained recent attention in Great Britain; however, this technique has not been widely accepted in the United States. At Wilford Hall USAF Medical Center, separator was beneficial in the management of a patient with Rh isoimmunization [16].
• The time course of appearance of AFPP-2 was also followed in patients with Rh isoimmunization syndrome and was found to be the same as that seen for SP-A [17].

References