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MeSH Review

Heinz Bodies

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Disease relevance of Heinz Bodies


High impact information on Heinz Bodies

  • Binding of Heinz bodies to the inner surface of the sickle cell membrane promotes clustering and colocalization of the membrane protein band 3, outer surface-bound autologous IgG and, to some extent, the membrane proteins glycophorin and ankyrin [2].
  • However, the EKLF-/- colonies were poorly hemoglobinized and enucleated erythrocytes in these colonies contained numerous Heinz bodies [3].
  • Moreover, exposure of intact RBC to 20 mmol/L APH induced depletion of procalpain activity for which the time course was inversely related to formation of Heinz bodies [4].
  • With 100 mg/dL phenylhydrazine, when the entire membrane was coated with Heinz bodies, RBC filterability and membrane deformability were drastically reduced [5].
  • These studies indicate that the erythrocytes of premature infants are uniquely sensitive to the development of Heinz bodies after exposure to sodium ascorbate [6].

Biological context of Heinz Bodies


Anatomical context of Heinz Bodies

  • Percent Heinz bodies in diabetic cats directly correlated with plasma beta-hydroxy-butyrate concentration (r = .622; P = .0002), as well as with serum chloride concentration (r = -0.576; P = 0.0009) and the number of monocytes (r = .536; P = .0023) [9].

Associations of Heinz Bodies with chemical compounds

  • Methylene blue potentiated the oxidative denaturation of haemoglobin by aniline as judged by the size and number of Heinz bodies and their turbidity in haemolysate [10].
  • Dapsone and Heinz bodies [11].
  • Heinz bodies induced by acetylphenylhydrazine in intact cells or in the presence of membrane remained attached to membrane when separated by a sucrose gradient [12].
  • The decrease in deformability starts even before Heinz body formation is recognized and is enhanced with PHZ as Heinz bodies are attached on the inner surface of the membrane, but remains at a low level in MMH-treated cells in which Heinz bodies are formed mostly away from the membrane surface [13].
  • Irreversible haemoglobin oxidation also occurred in these cells, shown by the formation of Heinz bodies; purified haemoglobin likewise suffered oxidative damage when incubated with sporidesmin in the presence of glutathione [14].

Gene context of Heinz Bodies


Analytical, diagnostic and therapeutic context of Heinz Bodies


  1. Chronic toxicity of pyrazolones: the problem of nitrosation. Kramer, M. British journal of clinical pharmacology. (1980) [Pubmed]
  2. Red cell membrane remodeling in sickle cell anemia. Sequestration of membrane lipids and proteins in Heinz bodies. Liu, S.C., Yi, S.J., Mehta, J.R., Nichols, P.E., Ballas, S.K., Yacono, P.W., Golan, D.E., Palek, J. J. Clin. Invest. (1996) [Pubmed]
  3. A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains. Lim, S.K., Bieker, J.J., Lin, C.S., Costantini, F. Blood (1997) [Pubmed]
  4. Favism: impairment of proteolytic systems in red blood cells. Morelli, A., Grasso, M., Meloni, T., Forteleoni, G., Zocchi, E., De Flora, A. Blood (1987) [Pubmed]
  5. Quantitative relationship between Heinz body formation and red blood cell deformability. Reinhart, W.H., Sung, L.P., Chien, S. Blood (1986) [Pubmed]
  6. Vitamin C-induced erythrocyte damage in premature infants. Ballin, A., Brown, E.J., Koren, G., Zipursky, A. J. Pediatr. (1988) [Pubmed]
  7. Hematological effects in F344 rats and B6C3F1 mice during the 13-week gavage toxicity study of methylene blue trihydrate. Hejtmancik, M.R., Ryan, M.J., Toft, J.D., Persing, R.L., Kurtz, P.J., Chhabra, R.S. Toxicol. Sci. (2002) [Pubmed]
  8. Verapamil prevents impairment in filterability of human erythrocytes exposed to oxidative stress. Okamoto, K., Maruyama, T., Kaji, Y., Harada, M., Mawatari, S., Fujino, T., Uyesaka, N. Jpn. J. Physiol. (2004) [Pubmed]
  9. Heinz body formation associated with ketoacidosis in diabetic cats. Christopher, M.M., Broussard, J.D., Peterson, M.E. J. Vet. Intern. Med. (1995) [Pubmed]
  10. Studies of the efficacy and potential hazards of methylene blue therapy in aniline-induced methaemoglobinaemia. Harvey, J.W., Keitt, A.S. Br. J. Haematol. (1983) [Pubmed]
  11. Dapsone and Heinz bodies. Rosove, M.H., Harwig, S.S., Ahmed, R.A. Archives of dermatology. (1985) [Pubmed]
  12. The role of disulphide bonds in Heinz body attachment to membranes. Chan, E., Desforges, J.F. Br. J. Haematol. (1976) [Pubmed]
  13. On the mechanism of loss of deformability in human erythrocytes due to Heinz body formation: a flow EPR study. Fukushima, Y., Kon, H. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  14. Studies on the mechanism of toxicity of the mycotoxin sporidesmin. 2--Evidence for intracellular generation of superoxide radical from sporidesmin. Munday, R. Journal of applied toxicology : JAT. (1984) [Pubmed]
  15. Equine glucose-6-phosphate dehydrogenase deficiency. Stockham, S.L., Harvey, J.W., Kinden, D.A. Vet. Pathol. (1994) [Pubmed]
  16. Serum hemopexin in patients with dermatitis herpetiformis on dapsone (di(4-aminophenyl)sulphone). Kastrup, W., Lindstedt, G., Lundberg, P.A., Mobacken, H. Archives for dermatological research. Archiv für dermatologische Forschung. (1975) [Pubmed]
  17. Nitrate induced anaemia in home dialysis patients. Salvadori, M., Martinelli, F., Comparini, L., Bandini, S., Sodi, A. Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress. (1985) [Pubmed]
  18. Induction of Heinz body formation by sodium dithionite. Imanishi, H., Hosokawa, K., Itano, H.A. Hemoglobin (1981) [Pubmed]
  19. Scanning electron microscopy of Heinz bodies in feline erythrocytes. Jain, N.C., Keeton, K.S. Am. J. Vet. Res. (1975) [Pubmed]
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