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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Work of Breathing

 
 
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Disease relevance of Work of Breathing

 

Psychiatry related information on Work of Breathing

  • We conclude that nocturnal nasal CPAP improves inspiratory muscle performance during wakefulness in COPD patients, which is very likely a product of the reduced work of breathing during sleep while these individuals received CPAP [6].
 

High impact information on Work of Breathing

  • Almost all of the work of breathing was inspiratory work at all ventilatory levels; thus, only blood flows to the diaphragm and external intercostals increased in the transition from mechanical to spontaneous ventilation, and they further increased linearly as ventilatory work was incrementally augmented ninefold by CO2 rebreathing [7].
  • As FEV(1) declines in children and young adults with CF, there is an increase in the elastic load and work of breathing, resulting in a rapid shallow breathing pattern, that is associated with further impairment of gas exchange [8].
  • At a standardized time near end-exercise, PS and CPAP reduced the work of breathing per minute by 39 +/- 8 and 25 +/- 4%, respectively (p < 0. 01) [9].
  • CONCLUSIONS: Flow-adapted tube compensation by the original ATC system significantly reduced tube-related inspiratory and expiratory work of breathing [10].
  • Reduced airway resistance and work of breathing during mechanical ventilation with an ultra-thin, two-stage polyurethane endotracheal tube (the Kolobow tube) [11].
 

Chemical compound and disease context of Work of Breathing

  • Concurrent bronchodilation and decreased REE after albuterol administration suggest that increased work of breathing as a result of airway obstruction may contribute to increased energy demands in horses with RAO [12].
  • Because heliox is less dense than air or nitrogen, it offers less resistance and turbulence as an inhaled gas and therefore decreases the pressure and work of breathing necessary to ventilate the lung, which assists in the management of conditions that involve airway obstruction [13].
 

Biological context of Work of Breathing

 

Anatomical context of Work of Breathing

  • One cannot predict accurately the O2 cost of exercise in the obese patient from the ergometer load because of uncertainties of distribution of the adipose tissue, the uncertain effects on breathing work, and often reduced motor efficiency or skill [19].
 

Associations of Work of Breathing with chemical compounds

  • During Heliox breathing, there was a significant decrease in pulmonary resistance, resistive work of breathing, and mechanical power of breathing, whereas ventilation remained unchanged [20].
  • Pulmonary compliance, resistance, and resistive work of breathing were determined, using least mean square analysis technique, daily for three days and after discontinuation of pancuronium (even though there was no clinical improvement in ventilatory management) [21].
  • These results suggest that, in diseases associated with increased work of breathing and decreased O2 delivery, the diaphragm may become metabolically impaired before limitation of VO2 is observed systemically [22].
  • The effects of airway impedance on work of breathing during halothane anesthesia [23].
  • They are consistent with the existence of an airway control system which adjusts airway calibre to minimise the work of breathing [24].
 

Gene context of Work of Breathing

  • Apparently, mechanical work of breathing was decreased in patients with severe COPD while breathing He-O2, leading to a reduction in VCO2 and improvement in overall alveolar ventilation [25].
  • To see if continuous distending pressure (CPD) given by nasal prongs increases work of breathing, we measured the mechanics of breathing, minute ventilation, and blood gases in nine infants with both nasal prong and face mask CDP [26].
  • Also, the values of work of breathing and VO2 obtained using the Newport Wave E200 were significantly (p < .05) lower than those values obtained using the Servo 900C [27].
  • Because work of breathing is less with the Bird VIP than the other two ventilators tested, leading to a corresponding decrease in VO2, we suggest that the Bird VIP better adapts the patient to the ventilator and may facilitate weaning from ventilatory support [27].
  • OBJECTIVE: To evaluate the impact of helium-oxygen (He/O2) on inspiratory effort and work of breathing (WOB) in intubated COPD patients ventilated with pressure support [28].

References

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  2. Blood transfusion and lung function in chronically anemic patients with severe chronic obstructive pulmonary disease. Schönhofer, B., Wenzel, M., Geibel, M., Köhler, D. Crit. Care Med. (1998) [Pubmed]
  3. Control of exercise hyperpnea during hypercapnia in humans. Poon, C.S., Greene, J.G. J. Appl. Physiol. (1985) [Pubmed]
  4. Controlled breathing and dyspnea in patients with chronic obstructive pulmonary disease (COPD). Gosselink, R. Journal of rehabilitation research and development. (2003) [Pubmed]
  5. Respiratory muscles and ventilatory failure: 1993 perspective. Rochester, D.F. Am. J. Med. Sci. (1993) [Pubmed]
  6. Nocturnal nasal continuous positive airway pressure in patients with chronic obstructive pulmonary disease. Influence on waking respiratory muscle function. Mezzanotte, W.S., Tangel, D.J., Fox, A.M., Ballard, R.D., White, D.P. Chest (1994) [Pubmed]
  7. The distribution of blood flow, oxygen consumption, and work output among the respiratory muscles during unobstructed hyperventilation. Robertson, C.H., Pagel, M.A., Johnson, R.L. J. Clin. Invest. (1977) [Pubmed]
  8. Changes in pulmonary mechanics with increasing disease severity in children and young adults with cystic fibrosis. Hart, N., Polkey, M.I., Clément, A., Boulé, M., Moxham, J., Lofaso, F., Fauroux, B. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  9. Ventilatory assistance improves exercise endurance in stable congestive heart failure. O'Donnell, D.E., D'Arsigny, C., Raj, S., Abdollah, H., Webb, K.A. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  10. Accuracy of automatic tube compensation in new-generation mechanical ventilators. Elsasser, S., Guttmann, J., Stocker, R., Mols, G., Priebe, H.J., Haberthür, C. Crit. Care Med. (2003) [Pubmed]
  11. Reduced airway resistance and work of breathing during mechanical ventilation with an ultra-thin, two-stage polyurethane endotracheal tube (the Kolobow tube). Velarde, C.A., Short, B.L., Rivera, O., Seale, W., Howard, R., Kolobow, T. Crit. Care Med. (1997) [Pubmed]
  12. Effect of aerosolized albuterol sulfate on resting energy expenditure determined by use of open-flow indirect calorimetry in horses with recurrent airway obstruction. Mazan, M.R., Hoffman, A.M., Kuehn, H., Deveney, E.F. Am. J. Vet. Res. (2003) [Pubmed]
  13. Therapeutic gases for neonatal and pediatric respiratory care. Myers, T.R. Respiratory care. (2003) [Pubmed]
  14. Respiratory muscle work compromises leg blood flow during maximal exercise. Harms, C.A., Babcock, M.A., McClaran, S.R., Pegelow, D.F., Nickele, G.A., Nelson, W.B., Dempsey, J.A. J. Appl. Physiol. (1997) [Pubmed]
  15. Pulmonary function measurements during repeated environmental challenge of horses with recurrent airway obstruction (heaves). Tesarowski, D.B., Viel, L., McDonell, W.N. Am. J. Vet. Res. (1996) [Pubmed]
  16. Histamine inhalation provocation test: method to identify nonspecific airway reactivity in equids. Klein, H.J., Deegen, E. Am. J. Vet. Res. (1986) [Pubmed]
  17. Chronopharmacodynamics and kinetics after symmetric and asymmetric multiple theophylline doses in patients with chronic obstructive pulmonary disease. Gimeno, F., van Veenen, R., Berg, W.C., Steenhuis, E.J., Jonkman, J.H., Weibel, M.A. International journal of clinical pharmacology, therapy, and toxicology. (1989) [Pubmed]
  18. Reduction in resting energy expenditure following lung volume reduction surgery in subjects with chronic obstructive pulmonary disease. McKeough, Z.J., Alison, J.A., Bayfield, n.u.l.l., Bye, P.T. Chronic respiratory disease. (2004) [Pubmed]
  19. The ventilatory stress of exercise in obesity. Whipp, B.J., Davis, J.A. Am. Rev. Respir. Dis. (1984) [Pubmed]
  20. Mechanics and energetics of breathing helium in infants with bronchopulmonary dysplasia. Wolfson, M.R., Bhutani, V.K., Shaffer, T.H., Bowen, F.W. J. Pediatr. (1984) [Pubmed]
  21. Continuous skeletal muscle paralysis: effect on neonatal pulmonary mechanics. Bhutani, V.K., Abbasi, S., Sivieri, E.M. Pediatrics (1988) [Pubmed]
  22. Systemic and diaphragmatic oxygen delivery-consumption relationships during hemorrhage. Ward, M.E., Chang, H., Erice, F., Hussain, S.N. J. Appl. Physiol. (1994) [Pubmed]
  23. The effects of airway impedance on work of breathing during halothane anesthesia. Slee, T.A., Sharar, S.R., Pavlin, E.G., MacIntyre, P.E. Anesth. Analg. (1989) [Pubmed]
  24. The interaction of chemo- and mechanoreceptor signals in the control of airway calibre. Stein, J.F., Widdicombe, J.G. Respiration physiology. (1975) [Pubmed]
  25. Helium-oxygen breathing in severe chronic obstructive pulmonary disease. Swidwa, D.M., Montenegro, H.D., Goldman, M.D., Lutchen, K.R., Saidel, G.M. Chest (1985) [Pubmed]
  26. Increased work of breathing associated with nasal prongs. Goldman, S.L., Brady, J.P., Dumpit, F.M. Pediatrics (1979) [Pubmed]
  27. Mechanical ventilators optimized for pediatric use decrease work of breathing and oxygen consumption during pressure-support ventilation. el-Khatib, M.F., Chatburn, R.L., Potts, D.L., Blumer, J.L., Smith, P.G. Crit. Care Med. (1994) [Pubmed]
  28. Helium-oxygen decreases inspiratory effort and work of breathing during pressure support in intubated patients with chronic obstructive pulmonary disease. Tassaux, D., Gainnier, M., Battisti, A., Jolliet, P. Intensive care medicine. (2005) [Pubmed]
 
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