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Chemical Compound Review

heliox     helium; molecular oxygen

Synonyms: AC1L3XCD, AR-1J1470, 70356-00-2, Heliox,hyperbaric, Heliox, hyperbaric, ...
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Disease relevance of heliox


Psychiatry related information on heliox


High impact information on heliox


Chemical compound and disease context of heliox

  • There was no systematic difference between the two methods with regard to lung volume measurements: mean (SD) FRC values, corrected for body weight, were 22.9 (7.1) mL/kg for O2 and 23.4 (7.0) mL/kg for heliox [10].
  • Neuronal sensitivity to pressure, barosensitivity, is illustrated by high-pressure nervous syndrome, which manifests as increased central nervous system excitability when heliox or trimix is breathed at >15 atmospheres absolute (ATA) [11].
  • Compared to breathing nitrox, these data indicate that heliox improved the distribution of inspired gas, thereby recruiting more gas exchange units, improving gas exchange efficiency, reducing ventilatory and oxygen requirements, and attenuating lung inflammation [12].
  • Fifteen out of 78 infants with acute bronchiolitis consecutively admitted to PICU fulfilled the inclusion criteria: clinical score>or=5 or arterial oxygen saturation (SatO2)<or=92% or PCO2>50 mmHg, despite supportive therapy, nebulized L-epinephrine, and heliox therapy through non-rebreathing reservoir facemask [13].
  • The second trial, which recruited older patients (older than 40 years), showed greater improvement in PEF and dyspnea score with heliox-driven albuterol therapy in patients with lower pretreatment PEF [14].

Biological context of heliox

  • Although heliox improved gas exchange during HFOV in our model, increased tidal volume delivery may limit clinical applicability [4].
  • To study the effects of apneic pauses, sighs, and breathing patterns on functional residual capacity (FRC), we measured FRC repeatedly in 48 healthy preterm infants (weight at study 2,042 +/- 316 g [mean +/- SD], postconceptional age 36.6 +/- 2.0 wk), during unsedated sleep using a modified heliox/nitrogen washout technique [15].
  • During Heliox breathing, there was a significant decrease in pulmonary resistance, resistive work of breathing, and mechanical power of breathing, whereas ventilation remained unchanged [16].
  • Heliox improves hemodynamics in mechanically ventilated patients with chronic obstructive pulmonary disease with systolic pressure variations [17].
  • OBJECTIVES: To determine the effect of breathing helium-oxygen (HELIOX) mixtures on pulmonary gas exchange during severe asthma [18].

Anatomical context of heliox

  • Breathing a lower density gas mixture (Heliox) may have therapeutic value by decreasing the demands on the respiratory muscles and the caloric requirements for breathing [16].
  • Heliox therapy for acute vocal cord dysfunction [19].
  • In addition, the model suggests that switching to heliox breathing may prolong the existence of the bubble relative to breathing air for bubbles in spinal and adipose tissues [20].
  • We visually followed the resolution of micro air bubbles injected into adipose tissue, spinal white matter, muscle, and tendon of anesthetized rats recompressed to and held at 284 kPa while rats breathed air, oxygen, heliox 80:20, or heliox 50:50 [21].
  • Only the four bees in our sample with the highest body mass-specific thorax masses were able to hover in pure heliox [22].

Associations of heliox with other chemical compounds


Gene context of heliox


Analytical, diagnostic and therapeutic context of heliox


  1. Heliox in respiratory failure from obstructive lung disease. Polito, A., Fessler, H. N. Engl. J. Med. (1995) [Pubmed]
  2. Heliox in chronic obstructive pulmonary disease: lightening the airflow. Wedzicha, J.A. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  3. Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma. Manthous, C.A., Hall, J.B., Caputo, M.A., Walter, J., Klocksieben, J.M., Schmidt, G.A., Wood, L.D. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  4. Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury. Katz, A., Gentile, M.A., Craig, D.M., Quick, G., Meliones, J.N., Cheifetz, I.M. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  5. Does heliox decrease the need for intubation in acute bronchiolitis? Barnes, S.D. Crit. Care Med. (1998) [Pubmed]
  6. Changes in respiration in NREM sleep in hypercapnic chronic obstructive pulmonary disease. O'Donoghue, F.J., Catcheside, P.G., Eckert, D.J., McEvoy, R.D. J. Physiol. (Lond.) (2004) [Pubmed]
  7. Psychometric evaluation of divers performing a series of heliox non-saturation dives. Hodgson, M., Golding, J.F. Aviation, space, and environmental medicine. (1991) [Pubmed]
  8. Continuous changes in electroencephalographic topograms and auditory reaction time during simulated 21 ATA (atmospheres absolute) heliox saturation dives. Ozawa, K., Tatsuno, J. The Annals of physiological anthropology = Seiri Jinruigaku Kenkyūkai kaishi. (1989) [Pubmed]
  9. The utility of albuterol nebulized with heliox during acute asthma exacerbations. Kress, J.P., Noth, I., Gehlbach, B.K., Barman, N., Pohlman, A.S., Miller, A., Morgan, S., Hall, J.B. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  10. Comparison of heliox and oxygen as washing gases for the nitrogen washout technique in preterm infants. Poets, C.F., Rau, G.A., Gappa, M., Seidenberg, J. Pediatr. Res. (1996) [Pubmed]
  11. Pressure (< or=4 ATA) increases membrane conductance and firing rate in the rat solitary complex. Mulkey, D.K., Henderson, R.A., Putnam, R.W., Dean, J.B. J. Appl. Physiol. (2003) [Pubmed]
  12. Heliox attenuates lung inflammation and structural alterations in acute lung injury. Nawab, U.S., Touch, S.M., Irwin-Sherman, T., Blackson, T.J., Greenspan, J.S., Zhu, G., Shaffer, T.H., Wolfson, M.R. Pediatr. Pulmonol. (2005) [Pubmed]
  13. Nasal continuous positive airway pressure with heliox in infants with acute bronchiolitis. Martinón-Torres, F., Rodríguez-Núñez, A., Martinón-Sánchez, J.M. Respiratory medicine. (2006) [Pubmed]
  14. Beneficial effects of albuterol therapy driven by heliox versus by oxygen in severe asthma exacerbation. Lee, D.L., Hsu, C.W., Lee, H., Chang, H.W., Huang, Y.C. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. (2005) [Pubmed]
  15. Determinants of lung volume in spontaneously breathing preterm infants. Poets, C.F., Rau, G.A., Neuber, K., Gappa, M., Seidenberg, J. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  16. Mechanics and energetics of breathing helium in infants with bronchopulmonary dysplasia. Wolfson, M.R., Bhutani, V.K., Shaffer, T.H., Bowen, F.W. J. Pediatr. (1984) [Pubmed]
  17. Heliox improves hemodynamics in mechanically ventilated patients with chronic obstructive pulmonary disease with systolic pressure variations. Lee, D.L., Lee, H., Chang, H.W., Chang, A.Y., Lin, S.L., Huang, Y.C. Crit. Care Med. (2005) [Pubmed]
  18. Oxygenation in status asthmaticus improves during ventilation with helium-oxygen. Schaeffer, E.M., Pohlman, A., Morgan, S., Hall, J.B. Crit. Care Med. (1999) [Pubmed]
  19. Heliox therapy for acute vocal cord dysfunction. Reisner, C., Borish, L. Chest (1995) [Pubmed]
  20. A model of extravascular bubble evolution: effect of changes in breathing gas composition. Himm, J.F., Homer, L.D. J. Appl. Physiol. (1999) [Pubmed]
  21. Effect of combined recompression and air, oxygen, or heliox breathing on air bubbles in rat tissues. Hyldegaard, O., Kerem, D., Melamed, Y. J. Appl. Physiol. (2001) [Pubmed]
  22. Allometry of kinematics and energetics in carpenter bees (Xylocopa varipuncta) hovering in variable-density gases. Roberts, S.P., Harrison, J.F., Dudley, R. J. Exp. Biol. (2004) [Pubmed]
  23. Pressure-sensitive and -insensitive coupling in gamma-aminobutyric acid(A) receptors. Davies, D.L., McCauley, L.D., Bolger, M.B., Alkana, R.L. Psychopharmacology (Berl.) (2001) [Pubmed]
  24. Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Davies, D.L., Trudell, J.R., Mihic, S.J., Crawford, D.K., Alkana, R.L. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  25. Direct evidence for a cause-effect link between ethanol potentiation of GABA(A) receptor function and intoxication from hyperbaric studies in C57, LS, and SS mice. Davies, D.L., Alkana, R.L. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  26. Variations in flows and pressures during jet ventilation in the infant: a model study. Belaguid, A., Guenard, H. Pediatr. Pulmonol. (1994) [Pubmed]
  27. Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. Palange, P., Valli, G., Onorati, P., Antonucci, R., Paoletti, P., Rosato, A., Manfredi, F., Serra, P. J. Appl. Physiol. (2004) [Pubmed]
  28. Bronchodilator response in adult patients with cystic fibrosis: effects on large and small airways. van Haren, E.H., Lammers, J.W., Festen, J., van Herwaarden, C.L. Eur. Respir. J. (1991) [Pubmed]
  29. Effect of heliox breathing on dynamic hyperinflation in COPD patients. Pecchiari, M., Pelucchi, A., D'Angelo, E., Foresi, A., Milic-Emili, J., D'Angelo, E. Chest (2004) [Pubmed]
  30. Genetically determined differences in the antagonistic effect of pressure on ethanol-induced loss of righting reflex in mice. Alkana, R.L., Finn, D.A., Jones, B.L., Kobayashi, L.S., Babbini, M., Bejanian, M., Syapin, P.J. Alcohol. Clin. Exp. Res. (1992) [Pubmed]
  31. Gas density does not affect pulmonary acoustic transmission in normal men. Mahagnah, M., Gavriely, N. J. Appl. Physiol. (1995) [Pubmed]
  32. Effect of nitric oxide, perfluorocarbon, and heliox on minute volume measurement and ventilator volumes delivered. Devabhaktuni, V.G., Torres, A., Wilson, S., Yeh, M.P. Crit. Care Med. (1999) [Pubmed]
  33. Use of heliox in patients with severe exacerbation of chronic obstructive pulmonary disease. Gerbeaux, P., Gainnier, M., Boussuges, A., Rakotonirina, J., Nelh, P., Torro, D., Arnal, J.M., Jean, P. Crit. Care Med. (2001) [Pubmed]
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