Disease relevance of Pseudarthrosis

• Fifty-two patients with severe fractures, spondylolisthesis, or pseudoarthrosis of T10 to L5 were treated using a computer assisted technique on 1/2 the patients and performing the screw insertion manually for the other 1/2 [1].
• At the time of the follow-up assessment, the PAS group showed a reduced rate of pseudarthrosis (7% versus 24%), a reduced degree of slip (36% versus 59%), and a reduced lumbosacral kyphosis (14 degrees versus 26 degrees) in comparison with the AS group [2].
• Spinal fractures and pseudoarthrosis complicating ankylosing spondylitis: MRI manifestation and clinical significance [3].
• Complications included pseudarthrosis (3%), wound infection (9%), and transient C5 palsy (6%) [4].
• Spinal pseudarthrosis with paraplegia in ankylosing spondylitis. A case report [5].

High impact information on Pseudarthrosis

• Spinal pseudoarthrosis: a complication of ankylosing spondylitis [6].
• The higher-resolution direct coronal images facilitated the diagnosis of pseudarthrosis and increased confidence in interpretation of normal studies [7].
• Twenty-nine patients with navicular nonunion or pseudarthrosis, rheumatoid arthritis, recent fractures, soft-tissue alterations, and bone tumors were examined [8].
• Skeletal ailments such as short stature, kyphoscoliosis, tibial bowing and pseudarthrosis are common osseous manifestations of NF1 [9].
• Approximately 50% of neurofibromatosis type 1 (NF1) patients exhibit skeletal pathology, such as premature osteoporosis or pseudoarthroses [10].

Chemical compound and disease context of Pseudarthrosis

• Four patients had pseudarthroses, two underwent revised procedures with titanium implants without signs of infection at more than 2 years' follow-up [11].
• Fusion between the occipital and C2 segment was indicated in case of irreducible dens pseudoarthrosis [12].
• SUMMARY OF BACKGROUND DATA: The mechanism by which nicotine increases the pseudarthrosis rate of spine fusion is unknown [13].
• If nonunion occurs, the pseudarthrosis is generally between the posterior bone graft and the ring of C1 [14].
• The presence of a synovial pseudarthrosis as suggested by technetium scintigraphy mandates open excision of the lining membrane at the time of electrode insertion [15].

Biological context of Pseudarthrosis

• NF1 gene expression in mouse fracture healing and in experimental rat pseudarthrosis [16].

Anatomical context of Pseudarthrosis

• Furthermore, positive labeling for NF1 mRNA and protein was detected in endothelium in both the pseudarthrosis and in the fracture [16].
• The effect of alendronate on osteoclast and osteoblast function was studied in a novel spine pseudarthrosis model in rats [17].
• Complications included infections in ten patients (7%), pin loosening without infection in six (4%), loss of reduction in six (4%), symptomatic nonunion in six (4%), impaled flexor tendon in two (2%), asymptomatic pseudarthrosis in one (1%), pin migration in one (1%), median nerve injury in one (1%), and radial artery injury in one (1%) [18].
• CONCLUSION: MR patterns of ankylosing spondylitis are important in evaluating complications of fractures or pseudoarthrosis, as well as changes in dura, soft tissue, and ligaments [3].
• This paper reports our experience of using Vascularised Fibular Transfer in Treatment of Congenital Pseudoarthrosis of tibia in 12 cases [19].

Gene context of Pseudarthrosis

• Five months after radical resection of sclerotic tibial segments, Ilizarov fixation and administration of osteogenic protein-1 osteogenic device, the congenital pseudarthrosis of the tibia healed; at 45 months the tibia increased in size and the patient was fully weight bearing [20].
• A pseudoarthrosis was noted at the T11/12 level on plain radiographs and tomograms [21].
• CONCLUSION: Only 4% of patients undergoing average 2.75 level anterior OPLL surgery without anterior plate instrumentation required secondary posterior wiring and fusion for clinical instability associated with pseudarthrosis [22].
• Treatment of a congenital pseudarthrosis of the tibia by osteogenic protein-1 (bone morphogenetic protein-7): a case report [20].
• At an average follow-up of 6.3 years (range, 2.0 to 11.0 years), eighteen (95 per cent) of the nineteen pseudarthroses had healed [23].

Analytical, diagnostic and therapeutic context of Pseudarthrosis

• The causes of the instabilities were as follows: eight cases of nonunion of Type II odontoid fracture, four cases of rheumatoid arthritis, three cases of tumor, two cases of ligamentous instability, two cases of pseudoarthrosis after bone-wire fusion, two cases of halo noncompliance, and one case of Os odontoideum [24].
• At 5 weeks, the spines were explored, and all pseudarthroses were redecorticated and grafted with no graft, autograft, or OP-1 [25].
• Radiologic case. Clinics in diagnostic imaging (1). Ankylosing spondylitis with complication of pseudoarthrosis [26].
• A high rate of pseudarthrosis and a high overall rate of implant migration requiring surgical revision has been reported following posterior lumbar interbody fusion using BAK threaded cages [27].
• Congenital pseudarthrosis of the tibia: Part 1. European Pediatric Orthopaedic Society multicenter study of congenital pseudoarthrosis [28].

References