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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Muscle Cramp

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Disease relevance of Muscle Cramp


High impact information on Muscle Cramp


Chemical compound and disease context of Muscle Cramp


Biological context of Muscle Cramp

  • Therapeutic administration of carnitine shows promise in treating selected groups of patients who have altered carnitine homeostasis, resulting in improved cardiac function, increased exercise capacity, reduced muscle cramps, and reduced intradialytic complications [13].

Anatomical context of Muscle Cramp


Gene context of Muscle Cramp

  • In the present study we have identified and characterized the mutations underlying L-CPT I deficiency in six patients: five with classic symptoms of L-CPT I deficiency and one with symptoms that have not previously been associated with this disorder (muscle cramps and pain) [16].
  • We have examined two Caucasian brothers with myoadenylate deaminase (AMPD) deficiency who presented with exercise intolerance and muscle cramps [17].
  • Patients had fewer muscular cramps on HF than on HD (P<0.03) and required significantly less saline and plasma expander during HF than HD sessions [18].
  • Muscle cramps were seen in 24 patients, multiple fractures in one, symmetrical distal neuropathy in 18, and carpal tunnel syndrome in 9 [19].
  • Prevalence and characteristics of muscle cramps in patients with varicose veins [20].

Analytical, diagnostic and therapeutic context of Muscle Cramp


  1. Molecular genetic heterogeneity of myophosphorylase deficiency (McArdle's disease). Tsujino, S., Shanske, S., DiMauro, S. N. Engl. J. Med. (1993) [Pubmed]
  2. Phenotype modulators in myophosphorylase deficiency. Martinuzzi, A., Sartori, E., Fanin, M., Nascimbeni, A., Valente, L., Angelini, C., Siciliano, G., Mongini, T., Tonin, P., Tomelleri, G., Toscano, A., Merlini, L., Bindoff, L.A., Bertelli, S. Ann. Neurol. (2003) [Pubmed]
  3. Bezafibrate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hyperlipidaemia. Monk, J.P., Todd, P.A. Drugs (1987) [Pubmed]
  4. Oral taurine therapy for painful muscle cramp in liver cirrhosis. Yamamoto, S. Am. J. Gastroenterol. (1994) [Pubmed]
  5. Genotype-phenotype correlation in a family with late onset CMT and an MPZ lys236del mutation. Sowden, J.E., Logigian, E.L., Malik, K., Herrmann, D.N. J. Neurol. Neurosurg. Psychiatr. (2005) [Pubmed]
  6. Randomised controlled trial of hydroquinine in muscle cramps. Curtis, J.R. Lancet (1997) [Pubmed]
  7. Effect of hypertonic glucose on the muscular cramps of hemodialysis. Milutinovich, J., Graefe, U., Follette, W.C., Scribner, B.H. Ann. Intern. Med. (1979) [Pubmed]
  8. Dissociation of the dystroglycan complex in caveolin-3-deficient limb girdle muscular dystrophy. Herrmann, R., Straub, V., Blank, M., Kutzick, C., Franke, N., Jacob, E.N., Lenard, H.G., Kröger, S., Voit, T. Hum. Mol. Genet. (2000) [Pubmed]
  9. Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. Kanai, K., Kuwabara, S., Arai, K., Sung, J.Y., Ogawara, K., Hattori, T. Brain (2003) [Pubmed]
  10. Low-dose prazosin in patients with muscle cramps during hemodialysis. Sidhom, O.A., Odeh, Y.K., Krumlovsky, F.A., Budris, W.A., Wang, Z., Pospisil, P.A., Atkinson, A.J. Clin. Pharmacol. Ther. (1994) [Pubmed]
  11. Phenytoin-induced improvement in muscle cramping and insulin action in three patients with the syndrome of insulin resistance, acanthosis nigricans, and acral hypertrophy. Minaker, K.L., Flier, J.S., Landsberg, L., Young, J.B., Moxley, R.T., Kingston, W.J., Meneilly, G.S., Rowe, J.W. Arch. Neurol. (1989) [Pubmed]
  12. A randomized controlled trial of quinidine in the treatment of cirrhotic patients with muscle cramps. Lee, F.Y., Lee, S.D., Tsai, Y.T., Lai, K.H., Chao, Y., Lin, H.C., Wang, S.S., Lo, K.J. J. Hepatol. (1991) [Pubmed]
  13. The role of carnitine in normal and altered fatty acid metabolism. Hoppel, C. Am. J. Kidney Dis. (2003) [Pubmed]
  14. Patients with n-hexane induced polyneuropathy: a clinical follow up. Chang, Y.C. British journal of industrial medicine. (1990) [Pubmed]
  15. Transverse leukonychia in severe hypocalcemia. Foti, C., Cassano, N., Palmieri, V.O., Portincasa, P., Conserva, A., Lamuraglia, M., Palasciano, G., Vena, G.A. European journal of dermatology : EJD. (2004) [Pubmed]
  16. Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme. Brown, N.F., Mullur, R.S., Subramanian, I., Esser, V., Bennett, M.J., Saudubray, J.M., Feigenbaum, A.S., Kobari, J.A., Macleod, P.M., McGarry, J.D., Cohen, J.C. J. Lipid Res. (2001) [Pubmed]
  17. Myoadenylate deaminase deficiency caused by alternative splicing due to a novel intronic mutation in the AMPD1 gene. Isackson, P.J., Bujnicki, H., Harding, C.O., Vladutiu, G.D. Mol. Genet. Metab. (2005) [Pubmed]
  18. Predilution haemofiltration--the Second Sardinian Multicentre Study: comparisons between haemofiltration and haemodialysis during identical Kt/V and session times in a long-term cross-over study. Altieri, P., Sorba, G., Bolasco, P., Asproni, E., Ledebo, I., Cossu, M., Ferrara, R., Ganadu, M., Cadinu, F., Serra, G., Cabiddu, G., Sau, G., Casu, D., Passaghe, M., Bolasco, F., Pistis, R., Ghisu, T. Nephrol. Dial. Transplant. (2001) [Pubmed]
  19. Musculoskeletal manifestations in hemodialysis patients. Chou, C.T., Wasserstein, A., Schumacher, H.R., Fernandez, P. J. Rheumatol. (1985) [Pubmed]
  20. Prevalence and characteristics of muscle cramps in patients with varicose veins. Hirai, M. VASA (2000) [Pubmed]
  21. Randomised controlled trial of hydroquinine in muscle cramps. Jansen, P.H., Veenhuizen, K.C., Wesseling, A.I., de Boo, T., Verbeek, A.L. Lancet (1997) [Pubmed]
  22. Amyotrophic lateral sclerosis: comprehensive management. DeLisa, J.A., Mikulic, M.A., Miller, R.M., Melnick, R.R. American family physician. (1979) [Pubmed]
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