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MeSH Review


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Disease relevance of Tetany


High impact information on Tetany


Chemical compound and disease context of Tetany

  • The tetany group had significantly lower serum 25OHD levels and higher 1,25(OH)2D levels, and had increased 1,25(OH)2D/25OHD as an index of the renal 25OHD-1-hydroxylase activity than those in the nontetany group [11].
  • Upon the institution of cortisol therapy, while still under the effects of a vitamin D analog dihydrotachysterol (DHT), the patient exhibited severe hypocalcemia and tetany [12].
  • Serum iPTHrP levels were not detectable (< 4 pmol/L) in 9 of 11 patients with postoperative hypocalcemia who presented with transient tetany, in 1 patient with hypocalcemia due to hypomagnesemia induced by cisplatin treatment, in normal subjects (n = 60), or in 1 normocalcemic patient with pseudopseudohypoparathyroidism [13].
  • Intravenously administered calcium gluconate has become increasingly popular in the treatment of neonatal tetany [14].
  • Fish fed unsupplemented diets (pyridoxine content of 1.2 mg/kg) were characterized by anoxeria, nervous disorders, tetany, greenish-blue body coloration, and eventual mortality [15].

Biological context of Tetany


Anatomical context of Tetany


Gene context of Tetany

  • If the diet contained phosphate, op/op mice died from hypocalcemic tetany when calcium was also removed from the diet [20].
  • In rabbits showing hypocalcemic tetany, calcitonin immunoreactivity was very intense and NSE immunoreactivity was faint to negative in the C cells [21].
  • Biochemical evidence for hypoparathyroidism and roentgenographic evidence for hyperparathyroidism were present in a 7-year-old girl with seizures and tetany [22].
  • Hypocalcemic tetany caused by PTH deficiency started between age of 6-13 y and was well controlled by small amounts of 1.25-(OH)2-cholecalciferol [23].
  • These results suggest that patients with a high serum level of iPTH as a result of low serum calcium levels (secondary hyperparathyroidism) are susceptible to tetany under conditions of hypoparathyroid function after surgery [11].

Analytical, diagnostic and therapeutic context of Tetany


  1. Parathyroidectomy reduces 25-hydroxyvitamin D3-1 alpha-hydroxylase activity in the hypocalcemic vitamin D-deficient chick. Booth, B.E., Tsai, H.C., Morris, R.C. J. Clin. Invest. (1977) [Pubmed]
  2. A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels. Grolleau, F., Gamelin, L., Boisdron-Celle, M., Lapied, B., Pelhate, M., Gamelin, E. J. Neurophysiol. (2001) [Pubmed]
  3. Parathyroid function tests with EDTA infusions in infancy and childhood. Tsang, R.C., Chen, I.W., McEnery, P., Brown, D.R., Johnson, J.R., Lesniewicz, J. J. Pediatr. (1976) [Pubmed]
  4. Primary hyperparathyroidism, pregnancy, and neonatal hypocalcemia. Kaplan, E.L., Burrington, J.D., Klementschitsch, P., Taylor, J., Deftos, L. Surgery (1984) [Pubmed]
  5. Tocainide therapy in muscle cramps and spasms due to neuromuscular disease. Puniani, T.S., Bertorini, T.E. Muscle Nerve (1991) [Pubmed]
  6. Tetany associated with nifedipine. Bosso, J.V., Gazzara, P.C., Rosati, M. N. Engl. J. Med. (1986) [Pubmed]
  7. Tetany associated with cis-platin. Stuart-Harris, R., Ponder, B.A., Wrigley, P.F. Lancet (1980) [Pubmed]
  8. Magnesium therapy in neonatal tetany. Turner, T.L., Cockburn, F., Forfar, J.O. Lancet (1977) [Pubmed]
  9. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Xue, Y., Karaplis, A.C., Hendy, G.N., Goltzman, D., Miao, D. Hum. Mol. Genet. (2005) [Pubmed]
  10. Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice. Xue, Y., Zhang, Z., Karaplis, A.C., Hendy, G.N., Goltzman, D., Miao, D. J. Bone Miner. Res. (2005) [Pubmed]
  11. Postoperative tetany in Graves disease: important role of vitamin D metabolites. Yamashita, H., Murakami, T., Noguchi, S., Shiiba, M., Watanabe, S., Uchino, S., Kawamoto, H., Toda, M., Murakami, N. Ann. Surg. (1999) [Pubmed]
  12. Cortisol-dihydrotachysterol antagonism in a patient with hypoparathyroidism and adrenal insufficiency: apparent inhibition of bone resorption. Farrell, P.M., Rikkers, H., Moel, D. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  13. Increased serum immunoreactive parathyroid hormone-related protein levels in chronic hypocalcemia. Mune, T., Katakami, H., Morita, M., Noguchi, S., Ushiroda, Y., Matsukura, S., Yasuda, K., Miura, K. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  14. Bone scintigraphy for neonatal osteomyelitis: simulation by extravasation of intravenous calcium. Balsam, D., Goldfarb, C.R., Stringer, B., Farruggia, S. Radiology. (1980) [Pubmed]
  15. Pyridoxine requirements of channel catfish. Andrews, J.W., Murai, T. J. Nutr. (1979) [Pubmed]
  16. Intrauterine growth retardation in a woman with primary hyperparathyroidism. A case report. Graham, E.M., Freedman, L.J., Forouzan, I. The Journal of reproductive medicine. (1998) [Pubmed]
  17. Alterations in sympathetic ganglionic transmission in response to angiotensin II in (mRen2)27 transgenic rats. Aileru, A.A., Logan, E., Callahan, M., Ferrario, C.M., Ganten, D., Diz, D.I. Hypertension (2004) [Pubmed]
  18. Partial DiGeorge syndrome with substantial cell-mediated immunity. Pabst, H.F., Wright, W.C., LeRiche, J., Stiehm, E.R. Am. J. Dis. Child. (1976) [Pubmed]
  19. Long-term follow-up of mitral valve prolapse and latent tetany. Preliminary data. Frances, Y., Collet, F., Luccioni, R. Magnesium. (1986) [Pubmed]
  20. Hypophosphatemia and the development of rickets in osteopetrotic (op/op) mice. McCary, L.C., Smith, C.M., DeLuca, H.F. J. Bone Miner. Res. (1997) [Pubmed]
  21. Increased level of immunoreactive neuron-specific enolase in thyroid C cells from dogs and guinea pigs after chronic hypercalcemia. Kameda, Y. Endocrinology (1985) [Pubmed]
  22. Hypo-hyperparathyroidism: evidence for a defective parathyroid hormone. Connors, M.H., Irias, J.J., Golabi, M. Pediatrics (1977) [Pubmed]
  23. Hypoparathyroidism and deafness associated with pleioplasmic large scale rearrangements of the mitochondrial DNA: a clinical and molecular genetic study of four children with Kearns-Sayre syndrome. Wilichowski, E., Grüters, A., Kruse, K., Rating, D., Beetz, R., Korenke, G.C., Ernst, B.P., Christen, H.J., Hanefeld, F. Pediatr. Res. (1997) [Pubmed]
  24. Primary hyperparathyroidism in cats: seven cases (1984-1989). Kallet, A.J., Richter, K.P., Feldman, E.C., Brum, D.E. J. Am. Vet. Med. Assoc. (1991) [Pubmed]
  25. Fatal privet (Ligustrum amurease) toxicosis in Tennessee cows. Kerr, L.A., Kelch, W.J. Veterinary and human toxicology. (1999) [Pubmed]
  26. A novel mutation in the GATA3 gene in a family with HDR syndrome (Hypoparathyroidism, sensorineural Deafness and Renal anomaly syndrome). Adachi, M., Tachibana, K., Asakura, Y., Tsuchiya, T. J. Pediatr. Endocrinol. Metab. (2006) [Pubmed]
  27. Adverse reactions to intravenous agents in anaesthesia in France. Laxenaire, M.C., Moneret-Vautrin, D.A., Boileau, S., Moeller, R. Klin. Wochenschr. (1982) [Pubmed]
  28. The functional status of the parathyroid in adult spasmophilia patients estimated by plasma parathormone assay. Lungu, G., Zosin, I., Deutsch, G., Berger, E., Miloş, A. Endocrinologie. (1981) [Pubmed]
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