High impact information on Tissue Transplantation

• Understanding why the H60 peptide is so immunogenic has important implications in tissue transplantation and vaccine design [1].
• Thus, PIR-A and PIR-B are counteracting receptors that are essential for successful tissue transplantation and may regulate irrelevant reaction to autologous tissues in a constitutive way in physiological conditions [2].
• The activity of IL-10 can be suppressed during inflammation, infection, or after allogeneic tissue transplantation [3].
• Cyclosporin A and FK-506 are important therapeutic agents that have found widespread use in preventing graft rejection during tissue transplantation [4].
• Microsurgical, tissue grafting and in situ hybridization techniques have been used to investigate the role of the neural tube and notochord in the control of the myogenic bHLH genes, QmyoD, Qmyf5, Qmyogenin and the cardiac alpha-actin gene, during somite formation in stage 12 quail embryos [5].

Biological context of Tissue Transplantation

• A combination of a knockout mouse model, tissue transplantation, and gene expression analysis has been used to investigate the role of steroid hormones in mammary gland development [6].
• The HLA-B alleles showed distinct electrophoretic patterns in nondenaturing polyacrylamide gels, depending on the nucleotide sequences of the exon 2, indicating that the SSCP analysis may be an alternative, useful and practical HLA-matching system of HLA-B specificity in tissue transplantation [7].

Anatomical context of Tissue Transplantation

• This preliminary trial demonstrates that the tissue transplantation of the parathyroid gland is effective to lessen the symptoms and medication of postoperative hypoparathyroidism [8].

Associations of Tissue Transplantation with chemical compounds

• A lateral tissue grafting procedure (G. Webster and L. Wolpert, 1966, J. Embryol. Exp. Morphol. 16, 91-104), was used to examine and compare the relative levels of these potentials in the normal and the mutant strains [9].
• CONCLUSION: Improvement was not sufficient to justify adrenal transplants as routine therapy but does point the way to the use of other dopamine tissue transplantation [10].
• When dihydrotestosterone (DHT) was administered at tissue grafting, both the incidence and size of the tissue grafts increased [11].
• In the second group (n=48), dexamethasone was administered in addition to fetal cortical tissue transplantation [12].
• Combination immunosuppression with FK-506 and RS-61443, therefore, may be required to allow composite tissue transplantation to become a predictable clinical reality in the future [13].

Gene context of Tissue Transplantation

• Minor histocompatibility (H) Ag are recognized in the context of MHC class I (K/D) molecules and can constitute a strong barrier to tissue transplantation [14].
• RESULTS: Using a tissue transplantation technique, we show that Xenopus CNC cells overexpressing wild-type ADAM 13 migrate along the same hyoid, branchial, and mandibular pathways used by normal CNC cells [15].
• The discovery of the human MHC in 1967 launched the field of organ and tissue transplantation [16].
• To study the role of Slug in Xenopus laevis, we used the injection of XSlug antisense RNA and tissue transplantation [17].
• We used IGF-I knockout (KO) mice and tissue grafting to determine the roles of local and systemic IGF-I in uterine growth and E2 responsiveness [18].

Analytical, diagnostic and therapeutic context of Tissue Transplantation

• Animals receiving fetal kidney tissue transplantation developed significantly less body asymmetry, as compared to stroke animals that either did not receive transplantation or received fetal kidney grafts and noggin pretreatment [19].

References