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Chemical Compound Review

Selenazofurin     2-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: CI-935, RSC II, CID3973, NSC-340847, DCL000600, ...
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Disease relevance of Selenazofurin


High impact information on Selenazofurin


Biological context of Selenazofurin


Anatomical context of Selenazofurin


Associations of Selenazofurin with other chemical compounds


Gene context of Selenazofurin

  • The NAD analogs of tiazofurin and selenazofurin were inhibitors of L1210 IMP dehydrogenase (IMP:NAD oxidoreductase, EC, and both showed uncompetitive inhibition with respect to NAD having Kii values of 5.7 X 10(-8)M and 3.3 X 10(-8)M respectively [15].
  • The dose-dependency for this inhibition correlates with the relative cytotoxicities of both drugs, indicating that a more potent inhibition of IMP dehydrogenase by the selenazole analog is primarily responsible for its increased cytotoxicity [14].


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  2. Activity of selenazofurin against influenza A and B viruses in vitro. Sidwell, R.W., Huffman, J.H., Call, E.W., Alaghamandan, H., Cook, P.D., Robins, R.K. Antimicrob. Agents Chemother. (1985) [Pubmed]
  3. Effects of selenazofurin and ribavirin and their 5'-triphosphates on replicative functions of influenza A and B viruses. Wray, S.K., Smith, R.H., Gilbert, B.E., Knight, V. Antimicrob. Agents Chemother. (1986) [Pubmed]
  4. Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent. Kirsi, J.J., North, J.A., McKernan, P.A., Murray, B.K., Canonico, P.G., Huggins, J.W., Srivastava, P.C., Robins, R.K. Antimicrob. Agents Chemother. (1983) [Pubmed]
  5. Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses. Huggins, J.W., Robins, R.K., Canonico, P.G. Antimicrob. Agents Chemother. (1984) [Pubmed]
  6. Modulation of cytotoxicity of benzamide riboside by expression of NMN adenylyltransferase. Yalowitz, J.A., Jayaram, H.N. Current medicinal chemistry. (2002) [Pubmed]
  7. Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis. Jayaram, H.N., Cooney, D.A., Grusch, M., Krupitza, G. Current medicinal chemistry. (1999) [Pubmed]
  8. Broad-spectrum synergistic antiviral activity of selenazofurin and ribavirin. Kirsi, J.J., McKernan, P.A., Burns, N.J., North, J.A., Murray, B.K., Robins, R.K. Antimicrob. Agents Chemother. (1984) [Pubmed]
  9. Tiazofurin and selenazofurin induce depression of cGMP and phosphatidylinositol pathway in L1210 leukemia cells. Parandoosh, Z., Robins, R.K., Belei, M., Rubalcava, B. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  10. Pyrazole-related nucleosides. 4. Synthesis and antitumor activity of some 1-tetrahydropyranyl-4-substituted pyrazoles. Manfredini, S., Bazzanini, R., Baraldi, P.G., Bonora, M., Marangoni, M., Simoni, D., Pani, A., Scintu, F., Pinna, E., Pisano, L., La Colla, P. Anticancer Drug Des. (1996) [Pubmed]
  11. Effect of selenazofurin on influenza A and B virus infections of mice. Sidwell, R.W., Huffman, J.H., Call, E.W., Alaghamandan, H., Cook, P.D., Robins, R.K. Antiviral Res. (1986) [Pubmed]
  12. Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin. Gharehbaghi, K., Sreenath, A., Hao, Z., Paull, K.D., Szekeres, T., Cooney, D.A., Krohn, K., Jayaram, H.N. Biochem. Pharmacol. (1994) [Pubmed]
  13. Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin. Franchetti, P., Cappellacci, L., Sheikha, G.A., Jayaram, H.N., Gurudutt, V.V., Sint, T., Schneider, B.P., Jones, W.D., Goldstein, B.M., Perra, G., De Montis, A., Loi, A.G., La Colla, P., Grifantini, M. J. Med. Chem. (1997) [Pubmed]
  14. Comparative in vitro studies of Tiazofurin and a selenazole analog. Streeter, D.G., Robins, R.K. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  15. Biochemical and antitumor activity of tiazofurin and its selenium analog (2-beta-D-ribofuranosyl-4-selenazolecarboxamide). Boritzki, T.J., Berry, D.A., Besserer, J.A., Cook, P.D., Fry, D.W., Leopold, W.R., Jackson, R.C. Biochem. Pharmacol. (1985) [Pubmed]
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