The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Hemorrhagic Fever with Renal Syndrome

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hemorrhagic Fever with Renal Syndrome


High impact information on Hemorrhagic Fever with Renal Syndrome


Chemical compound and disease context of Hemorrhagic Fever with Renal Syndrome


Biological context of Hemorrhagic Fever with Renal Syndrome


Anatomical context of Hemorrhagic Fever with Renal Syndrome


Gene context of Hemorrhagic Fever with Renal Syndrome


Analytical, diagnostic and therapeutic context of Hemorrhagic Fever with Renal Syndrome

  • A major obstacle in studying the medical aspects of HFRS and HPS has been the lack of an adequate animal model [24].
  • Equally high sensitivities and specificities for detection of PUU-specific IgM in acute-phase HFRS patient sera were obtained by the ELISA based on DES-PUU-N and the assay based on the native antigen [25].
  • SK/Aa, in comparison with a DOBV-Af isolate, was used for serotyping neutralizing antibodies of HFRS patients in Central Europe. Most patients' sera exhibited a higher endpoint titer when probed with our new isolate, suggesting that DOBV-Aa strains are responsible for most of the DOBV-caused HFRS cases in this region [26].
  • In search for the Norwegian nephropathia epidemica (NE) agent, lung sections from small rodents and sera from human patients have been tested by indirect fluorescent antibody technique (IFAT) [27].


  1. Pathogenic and nonpathogenic hantaviruses differentially regulate endothelial cell responses. Geimonen, E., Neff, S., Raymond, T., Kocer, S.S., Gavrilovskaya, I.N., Mackow, E.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Cross-neutralization of hantaviruses with immune sera from experimentally infected animals and from hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome patients. Chu, Y.K., Jennings, G., Schmaljohn, A., Elgh, F., Hjelle, B., Lee, H.W., Jenison, S., Ksiazek, T., Peters, C.J., Rollin, P. J. Infect. Dis. (1995) [Pubmed]
  3. Detection of nephropathia epidemica virus RNA in patient samples using a nested primer-based polymerase chain reaction. Grankvist, O., Juto, P., Settergren, B., Ahlm, C., Bjermer, L., Linderholm, M., Tärnvik, A., Wadell, G. J. Infect. Dis. (1992) [Pubmed]
  4. Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. Vapalahti, O., Kallio-Kokko, H., Salonen, E.M., Brummer-Korvenkontio, M., Vaheri, A. J. Gen. Virol. (1992) [Pubmed]
  5. Electrocardiographic changes in patients with haemorrhagic fever with renal syndrome. Puljiz, I., Kuzman, I., Markotić, A., Turcinov, D., Matić, M., Makek, N. Scand. J. Infect. Dis. (2005) [Pubmed]
  6. HFRS after a wild rodent bite in the Haute-Savoie--and risk of exposure to Hantaan-like virus in a Paris laboratory. Douron, E., Moriniere, B., Matheron, S., Girard, P.M., Gonzalez, J.P., Hirsch, F., McCormick, J.B. Lancet (1984) [Pubmed]
  7. Studies on immunopathogenesis in epidemic hemorrhagic fever: sequential observations on activation of the first complement component in sera from patients with epidemic hemorrhagic fever. Yan, D., Gu, X., Wang, D., Yang, S. J. Immunol. (1981) [Pubmed]
  8. Electron microscopy of nephropathia epidemica. Renal tubular basement membrane. Collan, Y., Lähdevirta, J., Jokinen, E.J. Am. J. Pathol. (1978) [Pubmed]
  9. Differential antiviral response of endothelial cells after infection with pathogenic and nonpathogenic hantaviruses. Kraus, A.A., Raftery, M.J., Giese, T., Ulrich, R., Zawatzky, R., Hippenstiel, S., Suttorp, N., Krüger, D.H., Schönrich, G. J. Virol. (2004) [Pubmed]
  10. Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome. Huggins, J.W., Hsiang, C.M., Cosgriff, T.M., Guang, M.Y., Smith, J.I., Wu, Z.O., LeDuc, J.W., Zheng, Z.M., Meegan, J.M., Wang, Q.N. J. Infect. Dis. (1991) [Pubmed]
  11. Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome. Linderholm, M., Ahlm, C., Settergren, B., Waage, A., Tärnvik, A. J. Infect. Dis. (1996) [Pubmed]
  12. Adjuvant activity of muramyl dipeptide derivatives to enhance immunogenicity of a hantavirus-inactivated vaccine. Yoo, Y.C., Yoshimatsu, K., Koike, Y., Hatsuse, R., Yamanishi, K., Tanishita, O., Arikawa, J., Azuma, I. Vaccine (1998) [Pubmed]
  13. Role of peripheral blood mononuclear cell (PBMC) phenotype changes in the pathogenesis of haemorrhagic fever with renal syndrome (HFRS). Markotić, A., Dasić, G., Gagro, A., Sabioncello, A., Rabatić, S., Kuzman, I., Zgorelec, R., Smoljan, I., Beus, I., Zupanc, T.A., Dekaris, D. Clin. Exp. Immunol. (1999) [Pubmed]
  14. Evaluation of renal tubular functions in convalescent phase of hemorrhagic fever with renal syndrome. Kim, G.H., Han, J.S., Earm, J., Jeon, U.S., Kim, Y.S., Ahn, C., Kim, S., Lee, J.S. American journal of nephrology. (1998) [Pubmed]
  15. Isolation of a Puumala-like virus from Mus musculus captured in Yugoslavia and its association with severe hemorrhagic fever with renal syndrome. Diglisic, G., Xiao, S.Y., Gligic, A., Obradovic, M., Stojanovic, R., Velimirovic, D., Lukac, V., Rossi, C.A., LeDuc, J.W. J. Infect. Dis. (1994) [Pubmed]
  16. Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. Lundkvist, A., Hukic, M., Hörling, J., Gilljam, M., Nichol, S., Niklasson, B. J. Med. Virol. (1997) [Pubmed]
  17. High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica. Kanerva, M., Vaheri, A., Mustonen, J., Partanen, J. Scand. J. Infect. Dis. (1998) [Pubmed]
  18. Bank vole monoclonal antibodies against Puumala virus envelope glycoproteins: identification of epitopes involved in neutralization. Lundkvist, A., Niklasson, B. Arch. Virol. (1992) [Pubmed]
  19. Hemorrhagic fever with renal syndrome: relationship between pathogenesis and cellular immunity. Huang, C., Jin, B., Wang, M., Li, E., Sun, C. J. Infect. Dis. (1994) [Pubmed]
  20. Peritubular capillary changes in alport syndrome, diabetic glomerulopathy, Balkan endemic nephropathy and hemorrhagic fever with renal syndrome. Hvala, A., Ferluga, D., Rott, T., Kobenter, T., Koselj-Kajtna, M., Trnacević, S. Ultrastructural pathology. (2005) [Pubmed]
  21. Characterization of glycoproteins of viruses causing hemorrhagic fever with renal syndrome (HFRS) using monoclonal antibodies. Dantas, J.R., Okuno, Y., Asada, H., Tamura, M., Takahashi, M., Tanishita, O., Takahashi, Y., Kurata, T., Yamanishi, K. Virology (1986) [Pubmed]
  22. Changes of lactate dehydrogenase and its isoenzyme activity in renal diseases. Kang, S.K., Ha, C.Y., Cho, K.H., Park, S.K., Kim, U.H. Nephron (1991) [Pubmed]
  23. Hemorrhagic fever with renal syndrome presenting with hemophagocytic lymphohistiocytosis. Lee, J.J., Chung, I.J., Shin, D.H., Cho, S.H., Cho, D., Ryang, D.W., Khan, A.S., Kim, H.J. Emerging Infect. Dis. (2002) [Pubmed]
  24. Wild-type Puumala hantavirus infection induces cytokines, C-reactive protein, creatinine, and nitric oxide in cynomolgus macaques. Klingström, J., Plyusnin, A., Vaheri, A., Lundkvist, A. J. Virol. (2002) [Pubmed]
  25. Diagnostic potential of puumala virus nucleocapsid protein expressed in Drosophila melanogaster cells. Brus Sjölander, K., Golovljova, I., Plyusnin, A., Lundkvist, A. J. Clin. Microbiol. (2000) [Pubmed]
  26. Central European Dobrava Hantavirus isolate from a striped field mouse (Apodemus agrarius). Klempa, B., Stanko, M., Labuda, M., Ulrich, R., Meisel, H., Krüger, D.H. J. Clin. Microbiol. (2005) [Pubmed]
  27. Nephropathia epidemica in Norway: description of serological response in human disease and implication of rodent reservoirs. Traavik, T., Mehl, R., Berdal, B.P., Lund, S., Dalrymple, J.M. Scand. J. Infect. Dis. (1983) [Pubmed]
WikiGenes - Universities