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Chemical Compound Review

AC1MHYMV     5-[(8S,9S,10S,13S,14S,17S)- 10,13-dimethyl...

Synonyms: SureCN377704
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Disease relevance of Bufadienolide


High impact information on Bufadienolide

  • In addition, the CoMFA results agreed well with the pharmacophore bufadienolide model for the parent PLC line proposed earlier [5].
  • Bufalin, a bufadienolide type cardiotonic steroid that is one of the major components of the toad venom-prepared traditional Chinese medicine called Ch'an Su or Senso, exhibits a cardiotonic action by inhibiting the membranous Na(+),K(+)-ATPase [6].
  • In the course of a screening program aimed at IL-6 inhibitor from natural products, we isolated 20S,21-epoxy-resibufogenin-3-formate (ERBF) from bufadienolide and examined the effect of ERBF on activities of various cytokines [7].
  • The effects of a bufadienolide isolated from toad venom, arenobufagin, a potent Na+/K+ pump inhibitor, were studied in single guinea-pig ventricular cells in the whole-cell patch-clamp configuration [8].
  • Now it appears that the inhibitors are steroids released from the adrenal gland and are members of the cardenolide family, e.g., ouabain, and the bufadienolide family, e.g., marinobufagenin [9].

Chemical compound and disease context of Bufadienolide


Biological context of Bufadienolide


Anatomical context of Bufadienolide


Associations of Bufadienolide with other chemical compounds


Gene context of Bufadienolide

  • Recently we demonstrated that, in addition to endogenous ouabain (EO), mammalian tissues contain another NKA inhibitor, a bufadienolide marinobufagenin (MBG) [21].
  • An increasing body of evidence suggests that an endogenous mammalian bufadienolide (BD) may be involved in the regulation of Na(+),K(+)-ATPase activity and the pathogenesis of arterial hypertension [17].


  1. Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer. Schoner, W., Scheiner-Bobis, G. Semin. Nephrol. (2005) [Pubmed]
  2. Involvement of marinobufagenin in a rat model of human preeclampsia. Vu, H.V., Ianosi-Irimie, M.R., Pridjian, C.A., Whitbred, J.M., Durst, J.M., Bagrov, A.Y., Fedorova, O.V., Pridjian, G., Puschett, J.B. American journal of nephrology. (2005) [Pubmed]
  3. The toxicity for cattle of bufadienolide cardiac glycosides from Bryophyllum tubiflorum flowers. McKenzie, R.A., Franke, F.P., Dunster, P.J. Aust. Vet. J. (1989) [Pubmed]
  4. Cardenolide and bufadienolide ligands of the sodium pump. How they work together in NaCl sensitive hypertension. Bagrov, A.Y., Fedorova, O.V. Front. Biosci. (2005) [Pubmed]
  5. QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1). Kamano, Y., Yamashita, A., Nogawa, T., Morita, H., Takeya, K., Itokawa, H., Segawa, T., Yukita, A., Saito, K., Katsuyama, M., Pettit, G.R. J. Med. Chem. (2002) [Pubmed]
  6. Enhancement of ligand-dependent vitamin D receptor transactivation by the cardiotonic steroid bufalin. Nakano, H., Matsunawa, M., Yasui, A., Adachi, R., Kawana, K., Shimomura, I., Makishima, M. Biochem. Pharmacol. (2005) [Pubmed]
  7. Biological activity of a novel nonpeptide antagonist to the interleukin-6 receptor 20S,21-epoxy-resibufogenin-3-formate. Hayashi, M., Rho, M.C., Fukami, A., Enomoto, A., Nonaka, S., Sekiguchi, Y., Yanagisawa, T., Yamashita, A., Nogawa, T., Kamano, Y., Komiyama, K. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  8. Depressive effects of arenobufagin on the delayed rectifier K+ current of guinea-pig cardiac myocytes. Cruz, J.d.o.s. .S., Matsuda, H. Eur. J. Pharmacol. (1994) [Pubmed]
  9. Role of dietary salt in hypertension. Haddy, F.J. Life Sci. (2006) [Pubmed]
  10. An outbreak of Cotyledon orbiculata L. poisoning in a flock of Angora goat rams. Tustin, R.C., Thornton, D.J., Kleu, C.B. Journal of the South African Veterinary Association. (1984) [Pubmed]
  11. Structure-cytotoxic activity relationship for the toad poison bufadienolides. Kamano, Y., Kotake, A., Hashima, H., Inoue, M., Morita, H., Takeya, K., Itokawa, H., Nandachi, N., Segawa, T., Yukita, A., Saitou, K., Katsuyama, M., Pettit, G.R. Bioorg. Med. Chem. (1998) [Pubmed]
  12. Substrate specificity for the 12beta-hydroxylation of bufadienolides by Alternaria alternata. Ye, M., Guo, D. J. Biotechnol. (2005) [Pubmed]
  13. Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives. Daniel, D., Süsal, C., Kopp, B., Opelz, G., Terness, P. Int. Immunopharmacol. (2003) [Pubmed]
  14. Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su. Nogawa, T., Kamano, Y., Yamashita, A., Pettit, G.R. J. Nat. Prod. (2001) [Pubmed]
  15. Proscillaridin A immunoreactivity: its purification, transport in blood by a specific binding protein and its correlation with blood pressure. Schneider, R., Antolovic, R., Kost, H., Sich, B., Kirch, U., Tepel, M., Zidek, W., Schoner, W. Clin. Exp. Hypertens. (1998) [Pubmed]
  16. The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum. Botha, C.J., Gehring, R., Van Rooyen, J.M., Venter, D. Onderstepoort J. Vet. Res. (2002) [Pubmed]
  17. Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that Is independent of cholesterol side-chain cleavage. Dmitrieva, R.I., Bagrov, A.Y., Lalli, E., Sassone-Corsi, P., Stocco, D.M., Doris, P.A. Hypertension (2000) [Pubmed]
  18. Simultaneous determination of bufadienolides in the traditional Chinese medicine preparation, liu-shen-wan, by liquid chromatography. Hong, Z., Chan, K., Yeung, H.W. J. Pharm. Pharmacol. (1992) [Pubmed]
  19. Insecticidal compounds from Kalanchoe daigremontiana x tubiflora. Supratman, U., Fujita, T., Akiyama, K., Hayashi, H. Phytochemistry (2001) [Pubmed]
  20. Biosynthesis of the bufadienolide ring of scillirosid in Scilla maritima. Galagovsky, L.R., Porto, A.M., Burton, G., Gros, E.G. Z. Naturforsch., C, Biosci. (1984) [Pubmed]
  21. Endogenous digitalis-like ligands and Na/K-ATPase inhibition in experimental diabetes mellitus. Bagrov, Y.Y., Manusova, N.B., Egorova, I.A., Fedorova, O.V., Bagrov, A.Y. Front. Biosci. (2005) [Pubmed]
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