Disease relevance of Bufadienolide

• The plasma concentration of the bufadienolide marinobufagenin is increased after cardiac infarction [1].
• The bufadienolide, marinobufagenin (MBG), an inhibitor of Na(+)/K(+) ATPase, has been found to be elevated in extracellular fluid volume-expanded hypertensive patients, a condition similar to preeclampsia [2].
• The toxicity for cattle of bufadienolide cardiac glycosides from Bryophyllum tubiflorum flowers [3].
• Cardenolide and bufadienolide ligands of the sodium pump. How they work together in NaCl sensitive hypertension [4].

High impact information on Bufadienolide

• In addition, the CoMFA results agreed well with the pharmacophore bufadienolide model for the parent PLC line proposed earlier [5].
• Bufalin, a bufadienolide type cardiotonic steroid that is one of the major components of the toad venom-prepared traditional Chinese medicine called Ch'an Su or Senso, exhibits a cardiotonic action by inhibiting the membranous Na(+),K(+)-ATPase [6].
• In the course of a screening program aimed at IL-6 inhibitor from natural products, we isolated 20S,21-epoxy-resibufogenin-3-formate (ERBF) from bufadienolide and examined the effect of ERBF on activities of various cytokines [7].
• The effects of a bufadienolide isolated from toad venom, arenobufagin, a potent Na+/K+ pump inhibitor, were studied in single guinea-pig ventricular cells in the whole-cell patch-clamp configuration [8].
• Now it appears that the inhibitors are steroids released from the adrenal gland and are members of the cardenolide family, e.g., ouabain, and the bufadienolide family, e.g., marinobufagenin [9].

Chemical compound and disease context of Bufadienolide

• Typical signs of acute bufadienolide cardiac glycoside toxicity were manifested and 6 animals died [10].

Biological context of Bufadienolide

• A valuable model which enables prediction of their activities was obtained from the CoMFA analysis, which may be employed for the drug designs of new bufadienolide analogues [11].
• For the biotransformation of bufalin, a 14beta-OH bufadienolide, this reaction was not specific, and accompanied by 7beta-hydroxylation as a parallel and competing metabolic route [12].
• The cytoplasmic and nuclear events of bufadienolide-induced apoptosis were strongly inhibited in the presence of caspase 8, caspase 9, or caspase 3 inhibitors, as well as in the presence of the broad-spectrum caspase inhibitor Z-VAD-FMK [13].
• Overexpression of Bcl-2 significantly protected bufadienolide-treated cells from phosphatidylserine translocation, transmembrane potential disruption, and internucleosomal DNA fragmentation [13].

Anatomical context of Bufadienolide

• In addition, bufadienolide 1 was found active against the MH-60 cancer cell line [14].
• A material crossreacting with antibodies against the bufadienolide proscillaridin A and inhibiting the sodium pump was found in human blood plasma [15].
• The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum [16].
• Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that Is independent of cholesterol side-chain cleavage [17].

Associations of Bufadienolide with other chemical compounds

• The bufadienolide compounds (bufalin, cinobufagin and resibufogenin), major constituents of Chansu in Liu-Shen-Wan (LSW), were determined by reverse phase high performance liquid chromatography [18].
• Methyl daigremonate, an insecticidal bufadienolide, was isolated from the leaves of Kalanchoe daigremontianaxtubiflora (Crassulaceae) along with four known bufadienolides [19].
• Biosynthesis of the bufadienolide ring of scillirosid in Scilla maritima [20].
• The contraction of rat jejunum with epoxyscillirosidin, a non-cumulative bufadienolide, and cotyledoside and tyledoside D, both cumulative neurotoxic bufadienolides were compared with methacholine [16].

Gene context of Bufadienolide

• Recently we demonstrated that, in addition to endogenous ouabain (EO), mammalian tissues contain another NKA inhibitor, a bufadienolide marinobufagenin (MBG) [21].
• An increasing body of evidence suggests that an endogenous mammalian bufadienolide (BD) may be involved in the regulation of Na(+),K(+)-ATPase activity and the pathogenesis of arterial hypertension [17].

References