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MeSH Review

Thoracic Duct

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Disease relevance of Thoracic Duct


High impact information on Thoracic Duct

  • To seek direct information on this question, we transferred unprimed LN or thoracic duct B cells from normal mice to xid mice, i.e., mice unresponsive to the T-independent antigen, trinitrophenyl (TNP)-Ficoll [6].
  • The requirement for C3 receptors on the precursors of antibody-forming cells was studied in an adoptive transfer system using thoracic duct lymphocytes (TDL) from primed rats as a source of precursors and irradiated recipients as hosts [7].
  • During euglycemic clamps (n = 7) in normal conscious dogs we simultaneously measured plasma and thoracic duct lymph insulin and glucose utilization (Rd) [8].
  • Lack of effect of somatostatin and analogues in lymphorrhagia from ruptured thoracic duct [9].
  • Integrin beta 7 was highly expressed on CD4+CD45R- "memory/effector" T cells recirculating through the gut (mesenteric efferent and lower thoracic duct lymph) [10].

Chemical compound and disease context of Thoracic Duct

  • Although the etiologic mechanism has not been defined, it is suggested the relationship of increased intrahepatic sinusoidal pressure on the thoracic duct and subsequent decreased lymph flow are interrelated to increased levels of aldosterone and manifested by (chylous) ascites [11].
  • Each lamb underwent two studies, interrupted by a 3-day period in which we drained protein-rich systemic lymph through a thoracic duct fistula and replaced fluid losses with feedings of a protein-free solution of electrolytes and glucose [12].
  • Labelled thoracic-duct lymph was collected from nonfasting rats with a bile fistula after simultaneous intraduodenal infusions of bile labelled with [1-2 3H] cholesterol and a nutritive mixture containing [4-14C] cholesterol [13].
  • Lymph from a thoracic duct fistula, prepared in advance, and from the blood of a peripheral vein was collected simultaneously along a time course after administration to measure the concentrations of FT-207 and 5-fluorouracil (5-FU) [14].
  • Fluid and protein flux responses in the left thoracic duct and vasculature were measured in pentobarbital-anesthetized, nephrectomized, adult dogs before and after four successive intravascular saline infusions of 2% of body weight each [15].

Biological context of Thoracic Duct


Anatomical context of Thoracic Duct


Associations of Thoracic Duct with chemical compounds


Gene context of Thoracic Duct


Analytical, diagnostic and therapeutic context of Thoracic Duct


  1. Immunoreactivity for interleukin 3 and 5 and granulocyte/macrophage colony-stimulating factor of intestinal mucosa in bronchial asthma. Wallaert, B., Desreumaux, P., Copin, M.C., Tillie, I., Benard, A., Colombel, J.F., Gosselin, B., Tonnel, A.B., Janin, A. J. Exp. Med. (1995) [Pubmed]
  2. Role of biliary phosphatidylcholine in the absorption and transport of dietary triolein in the rat. Tso, P., Kendrick, H., Balint, J.A., Simmonds, W.J. Gastroenterology (1981) [Pubmed]
  3. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Huang, X.Z., Wu, J.F., Ferrando, R., Lee, J.H., Wang, Y.L., Farese, R.V., Sheppard, D. Mol. Cell. Biol. (2000) [Pubmed]
  4. Subsets of circulating T-lymphocytes mediating resistance to in vivo growth of a carcinogen-induced syngeneic rat tumor. Crum, E.D. Cancer Res. (1984) [Pubmed]
  5. A subpopulation of T cells bearing Fc receptors. Basten, A., Miller, J.F., Warner, N.L., Abraham, R., Chia, E., Gamble, J. J. Immunol. (1975) [Pubmed]
  6. Prolonged survival in vivo of unprimed B cells responsive to a T-independent antigen. Ron, Y., Sprent, J. J. Exp. Med. (1985) [Pubmed]
  7. The requirement for C3 receptors on the precursors of 19S and 7S antibody-forming cells. Mason, D.W. J. Exp. Med. (1976) [Pubmed]
  8. Insulin transport across capillaries is rate limiting for insulin action in dogs. Yang, Y.J., Hope, I.D., Ader, M., Bergman, R.N. J. Clin. Invest. (1989) [Pubmed]
  9. Lack of effect of somatostatin and analogues in lymphorrhagia from ruptured thoracic duct. Van Gossum, A., Stefanidis, C., De Franquen, P. Lancet (1992) [Pubmed]
  10. Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph. Abitorabi, M.A., Mackay, C.R., Jerome, E.H., Osorio, O., Butcher, E.C., Erle, D.J. J. Immunol. (1996) [Pubmed]
  11. The hepatorenal syndrome: recovery after portacaval shunt. Ariyan, S., Sweeney, T., Kerstein, M.D. Ann. Surg. (1975) [Pubmed]
  12. Effect of hypoproteinemia on lung fluid balance in awake newborn lambs. Hazinski, T.A., Bland, R.D., Hansen, T.N., Sedin, E.G., Goldberg, R.B. J. Appl. Physiol. (1986) [Pubmed]
  13. Lymphatic transport of cholesterol from exogenous and biliary origins in nonfasting rats after intraduodenal infusions of triolein. Reisser, D., Boutillon, M.M., Clément, J. Ann. Nutr. Metab. (1983) [Pubmed]
  14. N1-(2 tetrahydrofuryl)-5-fluorouracil (FT-207) in the postoperative adjuvant chemotherapy of gastric cancer. Delivery of a fat-emulsified agent to the lymph. Hanaue, H., Kurosawa, T., Kitano, Y., Miyakawa, S., Horie, F., Nemoto, A., Shikata, J. Cancer (1986) [Pubmed]
  15. Thoracic duct lymph flow and protein flux dynamics: responses to intravascular saline. Brace, R.A., Power, G.G. Am. J. Physiol. (1981) [Pubmed]
  16. Characterization of recirculating lymphocytes in rheumatoid arthritis patients: selective deficiency of natural killer cells in thoracic duct lymph. Fox, R.I., Fong, S., Tsoukas, C., Vaughan, J.H. J. Immunol. (1984) [Pubmed]
  17. A comparison of the digestion and absorption of cocoa butter and palm kernel oil and their effects on cholesterol absorption in rats. Chen, I.S., Subramaniam, S., Vahouny, G.V., Cassidy, M.M., Ikeda, I., Kritchevsky, D. J. Nutr. (1989) [Pubmed]
  18. Basic fibroblast growth factor-mediated lymphangiogenesis of lymphatic endothelial cells isolated from dog thoracic ducts: effects of heparin. Tan, Y. Jpn. J. Physiol. (1998) [Pubmed]
  19. Does the autonomic nervous system regulate whole-body lymph flow? Power, G.G., Brace, R.A. Am. J. Physiol. (1983) [Pubmed]
  20. Physiology of B cells in mice with X-linked immunodeficiency. II. Influence of the thymus and mature T cells on B cell differentiation. Sprent, J., Bruce, J. J. Exp. Med. (1984) [Pubmed]
  21. Thoracic duct lymph. Relative contribution from splanchnic and muscle tissue. Steil, G.M., Meador, M.A., Bergman, R.N. Diabetes (1993) [Pubmed]
  22. An in vitro model of lymphocyte homing. II. Membrane and cytoplasmic events involved in lymphocyte adherence to specialized high-endothelial venules of lymph nodes. Woodruff, J.J., Katz, M., Lucas, L.E., Stamper, H.B. J. Immunol. (1977) [Pubmed]
  23. Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Poulin, R.A., Steil, G.M., Moore, D.M., Ader, M., Bergman, R.N. Diabetes (1994) [Pubmed]
  24. Unique cathepsin D-type proteases in rat thoracic duct lymphocytes and in rat lymphoid tissues. Yago, N., Bowers, W.E. J. Biol. Chem. (1975) [Pubmed]
  25. Effect of somatostatin on the flow rate and triglyceride levels of thoracic duct lymph in normal and vagotomized dogs. Nakabayashi, H., Sagara, H., Usukura, N., Yoshimitsu, K., Imamura, T., Seta, T., Yanase, E., Kawato, M., Hiraiwa, Y., Sakato, S., Takeda, R. Diabetes (1981) [Pubmed]
  26. Urinary metabolites of cis-9,10-methylene octadecanoic acid. cis-3,4-Methylene hexanedioic acid and related compounds. Greter, J., Lindstedt, S., Steen, G. J. Biol. Chem. (1979) [Pubmed]
  27. Lymphocyte recognition of lymph node high endothelium. I. Inhibition of in vitro binding by a component of thoracic duct lymph. Chin, Y.H., Carey, G.D., Woodruff, J.J. J. Immunol. (1980) [Pubmed]
  28. Segmental pancreatic transplantation with duct ligation or drainage to a jejunal Roux-en-Y loop in nonuremic diabetic patients. Groth, C.G., Lundgren, G., Gunnarsson, R., Arner, P., Berg, B., Ostman, J. Diabetes (1980) [Pubmed]
  29. Isoforms of apolipoprotein A-II in human plasma and thoracic duct lymph. Identification of proapolipoprotein A-II and sialic acid-containing isoforms. Lackner, K.J., Edge, S.B., Gregg, R.E., Hoeg, J.M., Brewer, H.B. J. Biol. Chem. (1985) [Pubmed]
  30. Cytokine profile of protective anti-Trichinella spiralis CD4+ OX22- and non-protective CD4+ OX22+ thoracic duct cells in rats: secretion of IL-4 alone does not determine protective capacity. Ramaswamy, K., Goodman, R.E., Bell, R.G. Parasite Immunol. (1994) [Pubmed]
  31. Synthesis and characterization of rat interleukin-10 (IL-10) cDNA clones from the RNA of cultured OX8- OX22- thoracic duct T cells. Goodman, R.E., Oblak, J., Bell, R.G. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  32. Comparison of carcinoembryonic antigen levels between portal and peripheral blood in patients with colorectal cancer. Correlation with histopathologic variables. Tabuchi, Y., Deguchi, H., Imanishi, K., Saitoh, Y. Cancer (1987) [Pubmed]
  33. The pattern of fibrillin deposition correlates with microfibril-associated glycoprotein 1 (MAGP-1) expression in cultured blood and lymphatic endothelial cells. Weber, E., Rossi, A., Solito, R., Aglianò, M., Sacchi, G., Gerli, R. Lymphology. (2004) [Pubmed]
  34. Reduction of lymphorrhagia from ruptured thoracic duct by somatostatin. Ulíbarri, J.I., Sanz, Y., Fuentes, C., Mancha, A., Aramendia, M., Sánchez, S. Lancet (1990) [Pubmed]
  35. In vitro response of bovine thoracic duct lymphocyte to phytohaemagglutinin following adult thymectomy. Sharbaugh, R.J., Ainsworth, S.K., Fitts, C.T. Clin. Exp. Immunol. (1976) [Pubmed]
  36. Octreotide in the treatment of lymphorrhea after axillary node dissection: a prospective randomized controlled trial. Carcoforo, P., Soliani, G., Maestroni, U., Donini, A., Inderbitzin, D., Hui, T.T., Lefor, A., Avital, I., Navarra, G. J. Am. Coll. Surg. (2003) [Pubmed]
  37. Relationships between the concentrations of doxycycline in serum and in thoracic duct lymph after oral and intravenous administration in man. Anderson, K.E., Dencker, H., Mårdh, P.A., Akerlund, M. Chemotherapy. (1976) [Pubmed]
  38. Somatostatin analog treatment of a cervical thoracic duct fistula. Valentine, C.N., Barresi, R., Prinz, R.A. Head & neck. (2002) [Pubmed]
  39. Isosulfan blue causes factitious methemoglobinemia in an infant. Burgoyne, L.L., Jay, D.W., Bikhazi, G.B., De Armendi, A.J. Paediatric anaesthesia. (2005) [Pubmed]
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