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Chemical Compound Review

Of-350     7-(chloromethyl)-1- azabicyclo[2.2.2]octane...

Synonyms: AC1L3DXY, AC1Q3BHN, AR-1C8795, LS-143102
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Disease relevance of 2-(chloromethyl)quinuclidine

  • METHODS: Of 350 cardiac transplant patients at our institution, 7 patients required mechanical ventricular assistance with the Abiomed BVS5000 assist device (Abiomed, Inc, Danvers, Mass) after transplant secondary to severe acute rejection with cardiogenic shock (n = 4) or primary graft failure (n = 3) [1].
  • STUDY DESIGN: Of 350 patients with incarcerated hernias who underwent operation between 1977 and 1994 at the Department of Surgery "A," Assaf Harofeh Medical Center, 14 had strangulated Richter's hernia [2].
  • Of 350 patients analyzed, 53 (15.1%) were not immune to rubella, and vaccination opportunities were missed [3].
  • Of 350 urine samples that grew E. coli, 77 (22%) were positive for ESBL; 34 of 84 (40.5%) samples that grew K. pneumoniae were ESBL-P [4].
  • Of 350 patients seen in a back pain clinic, 40% were found to have pain of thoracolumbar origin [5].

Psychiatry related information on 2-(chloromethyl)quinuclidine

  • RESULTS: Of 350 rats enrolled, 15 (4.2%) died due to anesthetic complications and 16 (4.5%) due to cannibalism and stress during transport [6].

High impact information on 2-(chloromethyl)quinuclidine

  • Of 350 mutagenized gametes examined, at least 10 independent recessive embryonic lethal mutations have been identified; an additional two are perinatal lethals [7].
  • Of 350 mutants tested, seven were identified with attenuated virulence that persisted after crossing the mutation back into a wild-type strain [8].
  • Of 350 subjects, 70 met the study criteria, which included established NIDDM (greater than or equal to 3 mo), suboptimal recent glycemic control, dietary fat intake greater than or equal to 35% of total energy intake, and body mass index greater than or equal to 25 kg/m2 [9].
  • For this study, smears were made by centrifugation in a Beckman Microfuge 11 (Beckman Instruments, Palo Alto, Calif.) and in parallel by using a Cytospin 2 apparatus (Shandon Inc., Pittsburgh, Pa.). Of 350 consecutive body fluid specimens examined, 50 (14.0%) grew bacteria [10].
  • SETTING: Department of Ophthalmology, Helsinki University Central Hospital, Helsinki, Finland. METHODS: Of 350 consecutive patients referred for their first laser Nd:YAG posterior capsulotomy, 235 eligible eyes were enrolled and 220 eyes completed the study [11].

Anatomical context of 2-(chloromethyl)quinuclidine


Gene context of 2-(chloromethyl)quinuclidine

  • RESULTS: Of 350 charts reviewed, 102 patients were admitted to the hospital for unstable COPD, 133 patients had stable COPD, 36 patients were admitted with unstable asthma, and 79 patients had stable asthma [13].
  • Of 350 patients identified worldwide, to date only six adults with SSADH deficiency have been reported in the literature [14].
  • Of 350 patients, 157 (45%) were at TNM Stage I, 47 (13%) at Stage II, 65 (19%) at Stage III, and 81 (23%) at Stage IV, according to the TNM stages defined in 1997 [15].
  • PATIENTS: Of 350 patients with cleft plate, 18 children were diagnosed with VCFS [16].

Analytical, diagnostic and therapeutic context of 2-(chloromethyl)quinuclidine


  1. BVS5000 support after cardiac transplantation. Petrofski, J.A., Patel, V.S., Russell, S.D., Milano, C.A. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  2. Richter's hernia--a surgical pitfall. Kadirov, S., Sayfan, J., Friedman, S., Orda, R. J. Am. Coll. Surg. (1996) [Pubmed]
  3. Rubella immunity in a cohort of pregnant women. McElhaney, R.D., Ringer, M., DeHart, D.J., Vasilenko, P. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (1999) [Pubmed]
  4. Prevalence and risk factors of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in an Israeli long-term care facility. Mendelson, G., Hait, V., Ben-Israel, J., Gronich, D., Granot, E., Raz, R. Eur. J. Clin. Microbiol. Infect. Dis. (2005) [Pubmed]
  5. Low back pain of thoracolumbar origin. Maigne, R. Archives of physical medicine and rehabilitation. (1980) [Pubmed]
  6. Videolaparoscopic orchiectomy and nephrectomy: training model in rats. Matheus, W.E., Leitão, V.A., Thiel, M., Palma, P.C., Fernandes, R.C., Netto, N.R. Urologia internationalis. (2006) [Pubmed]
  7. Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus. Shedlovsky, A., King, T.R., Dove, W.F. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Mylonakis, E., Idnurm, A., Moreno, R., El Khoury, J., Rottman, J.B., Ausubel, F.M., Heitman, J., Calderwood, S.B. Mol. Microbiol. (2004) [Pubmed]
  9. Impact of intensive educational approach to dietary change in NIDDM. Campbell, L.V., Barth, R., Gosper, J.K., Jupp, J.J., Simons, L.A., Chisholm, D.J. Diabetes Care (1990) [Pubmed]
  10. Clinical and laboratory analyses of cytospin-prepared Gram stains for recovery and diagnosis of bacteria from sterile body fluids. Chapin-Robertson, K., Dahlberg, S.E., Edberg, S.C. J. Clin. Microbiol. (1992) [Pubmed]
  11. Retinal breaks before and after neodymium:YAG posterior capsulotomy. Ranta, P., Tommila, P., Immonen, I., Summanen, P., Kivelä, T. Journal of cataract and refractive surgery. (2000) [Pubmed]
  12. More non-Q-wave myocardial infarctions but similar infarct sizes in patients with hypertension. Aursnes, I., Landmark, K. Blood Press. (2000) [Pubmed]
  13. Prehospitalization inhaled corticosteroid use in patients with COPD or asthma. Jackevicius, C., Joyce, D.P., Kesten, S., Chapman, K.R. Chest (1997) [Pubmed]
  14. Neurodevelopmental pattern of succinic semialdehyde dehydrogenase deficiency (gamma-hydroxybutyric aciduria). Philippe, A., Deron, J., Geneviève, D., de Lonlay, P., Gibson, K.M., Rabier, D., Munnich, A. Developmental medicine and child neurology. (2004) [Pubmed]
  15. Impact of tumor size on the clinical outcomes of patients with Robson State I renal cell carcinoma. Kinouchi, T., Saiki, S., Meguro, N., Maeda, O., Kuroda, M., Usami, M., Kotake, T. Cancer (1999) [Pubmed]
  16. Specific language impairment in children with velocardiofacial syndrome: four case studies. Goorhuis-Brouwer, S.M., Dikkers, F.G., Robinson, P.H., Kerstjens-Frederikse, W.S. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (2003) [Pubmed]
  17. Interventions for the treatment and management of chronic fatigue syndrome: a systematic review. Whiting, P., Bagnall, A.M., Sowden, A.J., Cornell, J.E., Mulrow, C.D., Ramírez, G. JAMA (2001) [Pubmed]
  18. Distinctive portal venographic pattern in patients with sclerotherapy resistant oesophageal varices. Toyonaga, A., Iwao, T., Sumino, M., Takagi, K., Oho, K., Shigemori, H., Tanikawa, K. J. Gastroenterol. Hepatol. (1996) [Pubmed]
  19. Cryotherapy versus podophyllin in the treatment of genital warts. Bashi, S.A. International journal of dermatology. (1985) [Pubmed]
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