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Gene Review

CNOT8  -  CCR4-NOT transcription complex, subunit 8

Homo sapiens

Synonyms: CAF1, CAF1-like protein, CAF2, CALIF, CALIFp, ...
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Disease relevance of CNOT8

  • BACKGROUND AND PURPOSE: The Caf1 secretion pathway of Yersinia pestis is one of the most well-characterized export machineries [1].
  • CONCLUSION: These results suggested that the recombinant hEGF was successfully secreted through the inner membrane of cells into the periplasm and then through the outer membrane into the medium via the action of the signal peptide of Y. pestis Caf1 in E. coli [1].
  • Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells [2].
  • CONCLUSIONS--There is a substantial prevalence of HIV infection among heterosexual clients in San Francisco (Calif) alcohol treatment programs, much of which is not associated with injection drug use [3].
  • DESIGN, SETTING, AND PATIENTS: Consecutive case series of 225 patients referred to a San Francisco, Calif, hospital with recent HIV-1 infection from June 1996 through June 2001 [4].

Psychiatry related information on CNOT8

  • To examine the extent and correlates of infection with herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in an inner-city community, we studied the prevalence of antibodies to these viruses and their association with risk behaviors in a representative sample of unmarried white, black, and Hispanic adults living in San Francisco, Calif. DESIGN [5].
  • METHODS: A total of 96 male combat veterans with PTSD diagnosed by DSM-III-R (72 from the West Haven, Conn, Veterans Affairs Medical Center and 24 from the Menlo Park, Calif, Veterans Affairs Medical Center) were compared with 24 male control subjects [6].
  • METHODS: A total of 244 current smokers were enrolled in an outpatient randomized blinded smoking cessation trial conducted at the San Francisco Veterans Affairs Medical Center, San Francisco, Calif. Of the 244 participants, 121 received a 7-week course of bupropion and 123 received placebo [7].
  • SETTING: The Aging Clinical Research Center of the Stanford (Calif) University Department of Psychiatry and Behavioral Science and the Geriatric Psychiatry Rehabilitation Unit of the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. PATIENTS AND OTHER PARTICIPANTS: Fifty patients with possible or probable AD [8].
  • Current drug disorders were higher among respondents who were younger, homeless longer, or sampled from the city of Oakland, Calif. Alcohol use disorders were higher among men than among women; surprisingly, drug use disorders were not [9].

High impact information on CNOT8

  • DESIGN, SETTING, AND SUBJECTS: Active surveillance for varicella conducted among the populations of Antelope Valley, Calif; Travis County, Tex; and West Philadelphia, Pa; from January 1, 1995, to December 31, 2000 [10].
  • OBJECTIVES: To determine the prevalence of KSHV infection in homosexual men in San Francisco, Calif, at the beginning of the HIV epidemic in 1978 and 1979 and to examine changes in prevalence of KSHV at time points from 1978 through 1996 in light of changes in sexual behavior [11].
  • SETTING AND PARTICIPANTS: Volunteer subsample from Chicago, Ill, and Oakland, Calif, consisting of 374 white and black men and women, aged 18 to 30 years at baseline, who participated in the Coronary Artery Risk Development in Young Adults (CARDIA) study [12].
  • SETTING: Veterans Affairs Medical Center in West Los Angeles, Calif. PATIENTS: Twenty patients (age range, 27-78 years; n=11 men) with hypothyroidism who were taking a stable long-term regimen of levothyroxine were included in the study [13].
  • SETTING: Referral center in San Francisco, Calif. PATIENTS: Volunteer sample of 24 eugonadal men with HIV-associated weight loss (mean, 9% body weight loss), recruited from an AIDS clinic and by referral and by advertisement [14].

Chemical compound and disease context of CNOT8

  • Postmenopausal estrogen use and heart disease risk factors in the 1980s. Rancho Bernardo, Calif, revisited [15].
  • METHOD: The authors studied six thinking patterns known to characterize childhood posttraumatic stress disorder and four additional hypothesized patterns in 153 randomly selected children of Concord, N.H. (who watched the explosion on television) and Porterville, Calif. (who heard about it later) [16].
  • This study was conducted to determine, on a prospective basis, the incidence of acute exertional rhabdomyolysis (AER) among recruits at the Marine Corps Recruit Depot, San Diego, Calif. Blood samples were taken from each of 337 volunteer recruits on each of their first six days of regularly scheduled training [17].
  • Pentosan polysulfate sodium (Elmiron; Alza Pharmaceuticals, Mountain View, Calif) is an oral preparation of pentosan polysulfate used in the symptomatic management of interstitial cystitis [18].
  • PURPOSE: To report the authors' initial experience in treating patients with wide-neck aneurysms with assistance from a recently developed neck-bridge device (TriSpan; Target Therapeutics/Boston Scientific, Fremont, Calif) [19].

Biological context of CNOT8


Anatomical context of CNOT8

  • SETTING--Three teaching nursing homes in Los Angeles, Calif. SUBJECTS--Eighty-four nursing home residents with trunk or trochanter pressure ulcers (Shea stage > or = 2) [25].
  • Characteristics of Los Angeles, Calif., residents in whom carcinomas of the cervix, vulva, vagina, anus, and penis were diagnosed during the period 1972-81 were compared with those of all residents and with those in whom any cancer was diagnosed during the same period [26].
  • SETTING: An academic referral setting, drawing from the Bay Area of San Francisco, Calif. RESULTS: Compared with controls, for the visuospatial working memory task, subjects with BD had greater activation in several areas including the bilateral ACC, left putamen, left thalamus, left DLPFC, and right inferior frontal gyrus [27].
  • RESULTS: Mean rectal temperatures exceeded concurrent oral readings by 0.4 degrees C +/- 0.4 degrees C (0.8 degrees F +/- 0.7 degrees F), which, in turn, exceeded concurrent tympanic membrane readings (obtained with a digital thermometer [IVAC Corp, San Diego, Calif]) by 0.4 degrees C +/- 1.1 degrees C (0.7 degrees F +/- 2.0 degrees F) [28].
  • Specific binding of Caf1 [K(d) = (5.4 +/- 0.1) x 10(-10) M] to interleukin-1 receptors (IL-1Rs) on the surface of finite mouse fibroblasts (line NIH 3T3) was observed [29].

Associations of CNOT8 with chemical compounds

  • After a test to determine maximal oxygen consumption (VO2max) each subject underwent three test sessions at 55% VO2max either in a control condition (CON) or with the CAF1 or CAF2 dose of caffeine [20].
  • Strains bearing deletions in either CCR4 or CAF1/POP2, which encode components of the cytoplasmic mRNA deadenylase complex, were particularly sensitive to HU [30].
  • DESIGN AND SETTING--In 1992, all of the active clinical and research faculty of Stanford University School of Medicine (n = 479), Palo Alto, Calif, were sent up to three mailings of a one-page questionnaire [31].
  • DESIGN: Prospective blinded study using the Tandem PSA and free PSA assays (Hybritech Inc, San Diego, Calif) [32].
  • Some cirrhotic patients were studied during nasogastric hyperalimentation with Vivonex (Norwich Eaton Pharmaceuticals, Norwich, N.Y.) as well as during total parenteral nutrition with FreAmine III (American McGaw, Irvine, Calif.); neither formula contains cyst(e)ine [33].

Other interactions of CNOT8


Analytical, diagnostic and therapeutic context of CNOT8

  • Conserved interactions of this factor with both NOT and CCR4 proteins and co-immunoprecipitation experiments suggest that CALIF is a bona fide component of the human CCR4-NOT complex [39].
  • SETTING: The Multicenter AIDS Cohort Study (MACS) in 4 urban areas (Baltimore, Md; Chicago, III; Los Angeles, Calif; and Pittsburgh, Pa) [40].
  • Ninety-six of 683 patients undergoing cholecystectomy at the Naval Regional Medical Center, Long Beach, Calif, from 1967 to 1974 were between 7 and 25 years old [41].
  • To evaluate the protective efficacy of polyribosylribitol phosphate (PRP) and polyribosylribitol phosphate-diphtheria toxoid (PRP-D) vaccines in children 18 to 59 months of age, we conducted a case-control study in Los Angeles (Calif) County between July 1, 1988, and July 31, 1989 [42].
  • SETTING: Ten day care centers for children of US Navy personnel in San Diego, Calif. PARTICIPANTS: A total of 149 day care attendees (aged 24-60 months) and their families were randomized; 127 children and their 328 household contacts received 2 vaccine doses and were included in the analysis [43].


  1. Secretion of biologically active human epidermal growth factor from Escherichia coli using Yersinia pestis Caf1 signal peptide. Liu, Y.L., Huang, L.M., Lin, W.P., Tsai, C.C., Lin, T.S., Hu, Y.H., Chen, H.S., Han, J.M., Wang, H.J., Liu, Y.T. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. (2006) [Pubmed]
  2. Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells. Vadgama, J.V., Scuric, Z., Chakrabarti, R., Marzo, E., Shen, D., Wu, Y. Int. J. Mol. Med. (2006) [Pubmed]
  3. HIV infection and risk behaviors among heterosexuals in alcohol treatment programs. Avins, A.L., Woods, W.J., Lindan, C.P., Hudes, E.S., Clark, W., Hulley, S.B. JAMA (1994) [Pubmed]
  4. Time trends in primary HIV-1 drug resistance among recently infected persons. Grant, R.M., Hecht, F.M., Warmerdam, M., Liu, L., Liegler, T., Petropoulos, C.J., Hellmann, N.S., Chesney, M., Busch, M.P., Kahn, J.O. JAMA (2002) [Pubmed]
  5. Prevalence and correlates of herpes simplex infections. The population-based AIDS in Multiethnic Neighborhoods Study. Siegel, D., Golden, E., Washington, A.E., Morse, S.A., Fullilove, M.T., Catania, J.A., Marin, B., Hulley, S.B. JAMA (1992) [Pubmed]
  6. Elevation of serum free triiodothyronine, total triiodothyronine, thyroxine-binding globulin, and total thyroxine levels in combat-related posttraumatic stress disorder. Mason, J., Southwick, S., Yehuda, R., Wang, S., Riney, S., Bremner, D., Johnson, D., Lubin, H., Blake, D., Zhou, G. Arch. Gen. Psychiatry (1994) [Pubmed]
  7. Bupropion for smoking cessation: a randomized trial. Simon, J.A., Duncan, C., Carmody, T.P., Hudes, E.S. Arch. Intern. Med. (2004) [Pubmed]
  8. Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease. Fama, R., Sullivan, E.V., Shear, P.K., Marsh, L., Yesavage, J.A., Tinklenberg, J.R., Lim, K.O., Pfefferbaum, A. Arch. Neurol. (1997) [Pubmed]
  9. Drug use disorders and treatment contact among homeless adults in Alameda County, California. Robertson, M.J., Zlotnick, C., Westerfelt, A. American journal of public health. (1997) [Pubmed]
  10. Varicella disease after introduction of varicella vaccine in the United States, 1995-2000. Seward, J.F., Watson, B.M., Peterson, C.L., Mascola, L., Pelosi, J.W., Zhang, J.X., Maupin, T.J., Goldman, G.S., Tabony, L.J., Brodovicz, K.G., Jumaan, A.O., Wharton, M. JAMA (2002) [Pubmed]
  11. Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. Osmond, D.H., Buchbinder, S., Cheng, A., Graves, A., Vittinghoff, E., Cossen, C.K., Forghani, B., Martin, J.N. JAMA (2002) [Pubmed]
  12. Association of hostility with coronary artery calcification in young adults: the CARDIA study. Coronary Artery Risk Development in Young Adults. Iribarren, C., Sidney, S., Bild, D.E., Liu, K., Markovitz, J.H., Roseman, J.M., Matthews, K. JAMA (2000) [Pubmed]
  13. Effect of calcium carbonate on the absorption of levothyroxine. Singh, N., Singh, P.N., Hershman, J.M. JAMA (2000) [Pubmed]
  14. Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: a randomized controlled trial. Strawford, A., Barbieri, T., Van Loan, M., Parks, E., Catlin, D., Barton, N., Neese, R., Christiansen, M., King, J., Hellerstein, M.K. JAMA (1999) [Pubmed]
  15. Postmenopausal estrogen use and heart disease risk factors in the 1980s. Rancho Bernardo, Calif, revisited. Barrett-Connor, E., Wingard, D.L., Criqui, M.H. JAMA (1989) [Pubmed]
  16. Children's thinking in the wake of Challenger. Terr, L.C., Bloch, D.A., Michel, B.A., Shi, H., Reinhardt, J.A., Metayer, S. The American journal of psychiatry. (1997) [Pubmed]
  17. Incidence of acute exertional rhabdomyolysis. Serum myoglobin and enzyme levels as indicators of muscle injury. Olerud, J.E., Homer, L.D., Carroll, H.W. Arch. Intern. Med. (1976) [Pubmed]
  18. Massive bleeding on a bladder protectant: a case report of pentosan polysulfate sodium-induced coagulopathy. Gill, S., Naiman, S.C., Jamal, A., Vickars, L.M. Arch. Intern. Med. (2002) [Pubmed]
  19. Neck-bridge device for endovascular treatment of wide-neck bifurcation aneurysms: initial experience. Raymond, J., Guilbert, F., Roy, D. Radiology. (2001) [Pubmed]
  20. The effects of two levels of caffeine ingestion on excess postexercise oxygen consumption in untrained women. Donelly, K., McNaughton, L. European journal of applied physiology and occupational physiology. (1992) [Pubmed]
  21. Methotrexate and misoprostol vs misoprostol alone for early abortion. A randomized controlled trial. Creinin, M.D., Vittinghoff, E. JAMA (1994) [Pubmed]
  22. Changes in AIDS survival time in two San Francisco cohorts of homosexual men, 1983 to 1993. Osmond, D., Charlebois, E., Lang, W., Shiboski, S., Moss, A. JAMA (1994) [Pubmed]
  23. Duplication and maintenance of heterochromatin domains. Taddei, A., Roche, D., Sibarita, J.B., Turner, B.M., Almouzni, G. J. Cell Biol. (1999) [Pubmed]
  24. The Chromatin Assembly Factor Subunit FASCIATA1 Is Involved in Homologous Recombination in Plants. Kirik, A., Pecinka, A., Wendeler, E., Reiss, B. Plant Cell (2006) [Pubmed]
  25. A randomized trial of low-air-loss beds for treatment of pressure ulcers. Ferrell, B.A., Osterweil, D., Christenson, P. JAMA (1993) [Pubmed]
  26. Parallels in the epidemiology of selected anogenital carcinomas. Peters, R.K., Mack, T.M., Bernstein, L. J. Natl. Cancer Inst. (1984) [Pubmed]
  27. Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Chang, K., Adleman, N.E., Dienes, K., Simeonova, D.I., Menon, V., Reiss, A. Arch. Gen. Psychiatry (2004) [Pubmed]
  28. Effects of anatomic site, oral stimulation, and body position on estimates of body temperature. Rabinowitz, R.P., Cookson, S.T., Wasserman, S.S., Mackowiak, P.A. Arch. Intern. Med. (1996) [Pubmed]
  29. Structural and functional similarity between Yersinia pestis capsular protein Caf1 and human interleukin-1 beta. Abramov, V.M., Vasiliev, A.M., Vasilenko, R.N., Kulikova, N.L., Kosarev, I.V., Khlebnikov, V.S., Ishchenko, A.T., MacIntyre, S., Gillespie, J.R., Khurana, R., Korpela, T., Fink, A.L., Uversky, V.N. Biochemistry (2001) [Pubmed]
  30. Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. Woolstencroft, R.N., Beilharz, T.H., Cook, M.A., Preiss, T., Durocher, D., Tyers, M. J. Cell. Sci. (2006) [Pubmed]
  31. Authors' criteria for selecting journals. Frank, E. JAMA (1994) [Pubmed]
  32. Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial. Catalona, W.J., Partin, A.W., Slawin, K.M., Brawer, M.K., Flanigan, R.C., Patel, A., Richie, J.P., deKernion, J.B., Walsh, P.C., Scardino, P.T., Lange, P.H., Subong, E.N., Parson, R.E., Gasior, G.H., Loveland, K.G., Southwick, P.C. JAMA (1998) [Pubmed]
  33. Plasma cysteine, cystine, and glutathione in cirrhosis. Chawla, R.K., Lewis, F.W., Kutner, M.H., Bate, D.M., Roy, R.G., Rudman, D. Gastroenterology (1984) [Pubmed]
  34. Glial fibrillary acidic protein expression in pleomorphic adenoma, chordoma, and astrocytoma. A comparison of three antibodies. Wittchow, R., Landas, S.K. Arch. Pathol. Lab. Med. (1991) [Pubmed]
  35. Extramammary Paget's disease: analysis of growth signal pathway from the human epidermal growth factor receptor 2 protein. Ogawa, T., Nagashima, Y., Wada, H., Akimoto, K., Chiba, Y., Nagatani, T., Inayama, Y., Yao, M., Aoki, I., Ikezawa, Z. Hum. Pathol. (2005) [Pubmed]
  36. Assessment of the trypsin-like human prostatic kallikrein, also known as hK2, in the seminal plasma of infertile men: respective contributions of an ELISA procedure and of Western blotting. Tremblay, R.R., Coulombe, E., Cloutier, S., Brunet, C., Deperthes, D., Frenette, G., Dubé, J.Y. J. Lab. Clin. Med. (1998) [Pubmed]
  37. Cyclo-oxygenase 2 expression in laryngeal squamous cell carcinoma and its clinical correlates. Bayazit, Y.A., Buyukberber, S., Sari, I., Camci, C., Ozer, E., Sevinc, A., Karakok, M., Kanlikama, M., Mumbuc, S. ORL J. Otorhinolaryngol. Relat. Spec. (2004) [Pubmed]
  38. Use of beta 2-microglobulin level and CD4 lymphocyte count to predict development of acquired immunodeficiency syndrome in persons with human immunodeficiency virus infection. Anderson, R.E., Lang, W., Shiboski, S., Royce, R., Jewell, N., Winkelstein, W. Arch. Intern. Med. (1990) [Pubmed]
  39. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits. Albert, T.K., Lemaire, M., van Berkum, N.L., Gentz, R., Collart, M.A., Timmers, H.T. Nucleic Acids Res. (2000) [Pubmed]
  40. Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators. Detels, R., Muñoz, A., McFarlane, G., Kingsley, L.A., Margolick, J.B., Giorgi, J., Schrager, L.K., Phair, J.P. JAMA (1998) [Pubmed]
  41. Cholelithiasis in persons under 25 years old. Clinicopathologic review of 96 cases. Goodman, D.B. JAMA (1976) [Pubmed]
  42. Protective efficacy of Haemophilus influenzae type b polysaccharide and conjugate vaccines in children 18 months of age and older. Greenberg, D.P., Vadheim, C.M., Bordenave, N., Ziontz, L., Christenson, P., Waterman, S.H., Ward, J.I. JAMA (1991) [Pubmed]
  43. Effectiveness of influenza vaccination of day care children in reducing influenza-related morbidity among household contacts. Hurwitz, E.S., Haber, M., Chang, A., Shope, T., Teo, S., Ginsberg, M., Waecker, N., Cox, N.J. JAMA (2000) [Pubmed]
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