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Chemical Compound Review

SureCN3935     4-chloronaphthalen-1-ol

Synonyms: AG-G-16925, ACMC-20amm7, C6788_SIGMA, C8302_SIGMA, C8890_SIGMA, ...
 
 
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Disease relevance of NSC 44345

  • When the nitrocellulose sheet was probed first with monoclonal antibody against EBV early antigen diffuse component (EA-D) and then stained with 4-chloro-1-naphthol, four polypeptides specific for EA-D were identified by purple bands [1].
  • Reaction with anti-rat immunoglobulin G conjugated to horseradish peroxidase and development in 4-chloro-1-naphthol resulted in colonies of naturally occurring smooth Brucella species staining purple [2].
  • After incubation of the papers in tissue culture supernatant monoclonal antibody against the peste-des-petits-ruminants virus, the antigen-antibody reaction was detected with peroxidase-conjugated anti-mouse immunoglobulin G and the enzyme substrate 4-chloro-1-naphthol [3].
  • The assay utilizes peroxidase conjugated anti-mouse immunoglobulin and 4-chloro-1-naphthol to detect the positive colonies and can detect on the order of 200 pg antigen per E. coli colony [4].
  • Analysis using anti-rabbit peroxidase conjugate and 4-chloro-1-naphthol and H2O2 solutions allowed direct detection of Listeria colonies which remained readily available for subsequent isolation [5].
 

High impact information on NSC 44345

 

Anatomical context of NSC 44345

  • The antigen-antibody complexes on the membranes were visualized with the oxidative coupling solution containing N,N'-dimethyl-p-phenylendiamine and 4-chloro-1-naphthol [10].
  • When ATS 3 (substrate diaminobencidinetetra-hydrochloride = DAB) and a 1.1 mixture of an anti-bursa serum and anti-thymus serum (ABS/ATS; substrate 4-chloro-1-naphthol = 4-Cl-1-N) were used simultaneously, thrombocytes revealed the brown color typical for DAB, whereas lymphocytes showed the blue stain of 4-Cl-1-N [11].
  • After bleaching the chromogen 4-chloro-1-naphthol and staining for lipofuscin pigment granules and basophilic material, 254 unequivocally relocated GAD-immunoreactive nerve cells could be classified as belonging to the lipofuscin pigment granules-containing class of interneurons [12].
  • A simple peroxidase staining method specific for eosinophils using 4-chloro-1-naphthol as substrate and 1,2,4-benzene triol as selective inhibitor is applied to the analysis of eosinophil colonies grown in soft-agar cultures form human blood or bone marrow [13].
 

Associations of NSC 44345 with other chemical compounds

 

Gene context of NSC 44345

  • Subsequently, the membrane was probed with goat anti-rabbit antibody conjugated to horseradish peroxidase and IL-1 proteins were detected by incubation with 4-chloro-1-naphthol and hydrogen peroxide [15].
  • The typing of haptoglobin samples, was facilitated by devising a method which utilizes the peroxidase activity of the haptoglobin-hemoglobin complex with 90-tolidine and hydrogen peroxide as substrates and 4-chloro-1-naphthol as coupler [16].
  • The antigen-antibody reaction was detected by PAP complexes (revealed by 4-chloro-1-naphthol) or with protein A-colloidal gold or IgG-colloidal gold [17].
  • With peroxidase conjugated anti-human IgG and 4-chloro-1-naphthol as a substrate, antibodies in trematodiasis patient sera were clearly detected on the strip as bluish purple spots [18].
 

Analytical, diagnostic and therapeutic context of NSC 44345

  • Immunohistochemistry was accomplished by staining for WGA and SP on adjacent sections by using the chromogen diaminobenzidine, or by staining on a single section with sequential application of WGA and SP antisera using the chromogens diaminobenzidine and 4-chloro-1-naphthol, respectively [19].
  • The use of the detection device in combination with luminol-based immunoassays resulted in greater signal intensities and increased sensitivity over that attainable with the commonly used chromogenic substrate, 4-chloro-1-naphthol [20].
  • Proteins are separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electrophoretically transferred to the membrane before specific immunostaining with either peroxidase/4-chloro-1-naphthol or immunogold/silver staining [21].
  • Procedures were carried out with different immunocytochemical methods, such as peroxidase-antiperoxidase and indirect immunofluorescence methods, visualized with diamino-benzidine, 4-chloro-1-naphthol and FITC stainings [22].

References

  1. Sequential detection of different antigens induced by Epstein-Barr virus and herpes simplex virus in the same Western blot by using dual antibody probes. Lin, J.C., Pagano, J.S. J. Virol. (1986) [Pubmed]
  2. Rapid identification of smooth Brucella species with a monoclonal antibody. Roop, R.M., Preston-Moore, D., Bagchi, T., Schurig, G.G. J. Clin. Microbiol. (1987) [Pubmed]
  3. Dot enzyme immunoassay for visual detection of peste-des-petits-ruminants virus antigen from infected caprine tissues. Obi, T.U., Ojeh, C.K. J. Clin. Microbiol. (1989) [Pubmed]
  4. Detection of E. coli colonies expressing the v-sis oncogene product with monoclonal antibodies made against synthetic peptides. Kennett, R.H., Leunk, R., Meyer, B., Silenzio, V. J. Immunol. Methods (1985) [Pubmed]
  5. A simple colony-blot method for identification of Listeria in food samples. Belyi, Y.F., Varfolomeeva, N.A., Tartakovskii, I.S. Med. Microbiol. Immunol. (Berl.) (1995) [Pubmed]
  6. Subtyping lymphocytes in peripheral blood by immunoperoxidase labeling and light scatter/absorption flow cytometry. Kim, Y.R., Martin, G., Paseltiner, L., Ansley, H., Ornstein, L., Kanter, R.J. Clin. Chem. (1985) [Pubmed]
  7. A rapid, sensitive myeloperoxidase stain using 4-chloro-1-naphthol. Elias, J.M. Am. J. Clin. Pathol. (1980) [Pubmed]
  8. Partial peroxidase deficiency in neutrophils and eosinophils associated with neurologic disease. Histochemical, cytochemical and biochemical studies. Bozdech, M.J., Bainton, D.F., Mustacchi, P. Am. J. Clin. Pathol. (1980) [Pubmed]
  9. An amplified mass piezoelectric immunosensor for Schistosoma japonicum. Wu, Z., Wu, J., Wang, S., Shen, G., Yu, R. Biosensors & bioelectronics. (2006) [Pubmed]
  10. Visualization of antigen on nitrocellulose membrane by the oxidative coupling reaction of N,N'-dimethyl-p-phenylenediamine and 4-chloro-1-naphthol. Kobayashi, R., Tashima, Y. Anal. Biochem. (1989) [Pubmed]
  11. Immunomorphologic characterization of chicken thrombocytes. Ries, S., Käufer, I., Reinacher, M., Weiss, E. Cell Tissue Res. (1984) [Pubmed]
  12. Glutamic acid decarboxylase (GAD)-immunoreactive structures in the adult human lateral geniculate nucleus. Zinner-Feyerabend, M., Braak, E. Anat. Embryol. (1991) [Pubmed]
  13. An improved cytochemical method for the evaluation of eosinophil colonies in soft-agar cultures from human blood or bone marrow. Dufer, J. Acta Histochem. (1985) [Pubmed]
  14. The use of tetramethylbenzidine for solid phase immunoassays. McKimm-Breschkin, J.L. J. Immunol. Methods (1990) [Pubmed]
  15. Quantitation of related proteins by Western blot analysis. Uhl, J., Newton, R.C. J. Immunol. Methods (1988) [Pubmed]
  16. C3, GBG, orosomucoid and haptoglobin polymorphisms. Improved staining methods. Tulchin, N., Ornstein, L., Weiner, P. Vox Sang. (1975) [Pubmed]
  17. Immunocytochemical localization of ACTH-like immunoreactivity in rat adrenal glomerulosa and fasciculata cells. Garcia-Caballero, T., Morel, G. Histochemistry (1989) [Pubmed]
  18. Multi-dot enzyme-linked immunosorbent assay for serodiagnosis of trematodiasis. Itoh, M., Sato, S. Southeast Asian J. Trop. Med. Public Health (1990) [Pubmed]
  19. Co-localization of retrogradely transported wheat germ agglutinin and the putative neurotransmitter substance P within trigeminal ganglion cells projecting to cat middle cerebral artery. Liu-Chen, L.Y., Gillespie, S.A., Norregaard, T.V., Moskowitz, M.A. J. Comp. Neurol. (1984) [Pubmed]
  20. A photodetection device for luminol-based immunodot and Western blotting assays. Leong, M.M., Fox, G.R., Hayward, J.S. Anal. Biochem. (1988) [Pubmed]
  21. Visualization of multiple protein bands on the same nitrocellulose membrane by double immunoblotting. Poor, M.L., Santa, P.F., Sittampalam, G.S. Anal. Biochem. (1988) [Pubmed]
  22. Localization of chromogranin A and B, beta-endorphin and enkephalins in the submandibular glands of mice. Letić-Gavrilović, A., Shibaike, S., Niina, M., Naruse, S., Abe, K. Shika Kiso Igakkai zasshi = Japanese journal of oral biology. (1989) [Pubmed]
 
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