Chemical Compound Review:
FAROPAFANT N',N'-dimethyl-N-(pyridin-3- ylmethyl)-N-[4...
Synonyms:
Foropafant, CHEMBL1628662, SureCN7156608, ANW-71420, AC1L3OON, ...
- Hypoxia primes endotoxin-induced tissue factor expression in human monocytes and endothelial cells by a PAF-dependent mechanism. Herbert, J.M., Corseaux, D., Lale, A., Bernat, A. J. Cell. Physiol. (1996)
- Effect of SR 27417 on oedema formation induced in rabbit skin by platelet-activating factor or antigen. Herbert, J.M., Laplace, M.C., Bernat, A., Salel, V., Maffrand, J.P. Eur. J. Pharmacol. (1992)
- Effect of various drugs on adriamycin-enhanced venous thrombosis in the rat: importance of PAF. Bernat, A., Herbert, J.M. Thromb. Res. (1994)
- Effect of SR 27417, a novel PAF antagonist on antigen-induced hypotension in the rat. Herbert, J.M., Bernat, A., Tibiriça, E. Journal of lipid mediators and cell signalling. (1997)
- Protective effect of SR 27417, a novel PAF antagonist, on PAF- or endotoxin-induced hypotension in the rat and the guinea-pig. Bernat, A., Herbert, J.M., Salel, V., Lespy, L., Maffrand, J.P. Journal of lipid mediators. (1992)
- Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. Thielman, N.M., Marcinkiewicz, M., Sarosiek, J., Fang, G.D., Guerrant, R.L. J. Clin. Invest. (1997)
- Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin. Guerrant, R.L., Fang, G.D., Thielman, N.M., Fonteles, M.C. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion. Kotelevets, L., Noë, V., Bruyneel, E., Myssiakine, E., Chastre, E., Mareel, M., Gespach, C. J. Biol. Chem. (1998)
- Platelet-activating factor induces NF-kappa B activation through a G protein-coupled pathway. Kravchenko, V.V., Pan, Z., Han, J., Herbert, J.M., Ulevitch, R.J., Ye, R.D. J. Biol. Chem. (1995)
- Characterization of specific binding sites of 3H-labelled platelet-activating factor ([3H]PAF) and a new antagonist, [3H]SR 27417, on guinea-pig tracheal epithelial cells. Herbert, J.M. Biochem. J. (1992)
- Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. Herbert, J.M., Castro-Faria-Neto, H.C., Barbosa-Filho, J.M., Cordeiro, R.S., Tibiriça, E. Journal of lipid mediators and cell signalling. (1997)
- Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. Herbert, J.M., Bernat, A., Valette, G., Gigo, V., Lale, A., LaPlace, M.C., Lespy, L., Savi, P., Maffrand, J.P., Le Fur, G. J. Pharmacol. Exp. Ther. (1991)
- In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. Bastos da Silva, M., Delaunois, A., Gustin, P., Godeau, J.M., Lekeux, P. Vet. Res. (2000)
- Binding of [3H]SR 27417, a novel platelet-activating factor (PAF) receptor antagonist, to rabbit and human platelets and polymorphonuclear leukocytes. Herbert, J.M., Laplace, M.C., Maffrand, J.P. Biochem. Pharmacol. (1993)
- Effect of SR 27417 on the binding of [3H]PAF to rabbit and human platelets and human polymorphonuclear leukocytes. Herbert, J.M., Laplace, M.C., Cailleau, C., Maffrand, J.P. Journal of lipid mediators. (1993)
- Prevention of platelet-activating factor-induced gastrointestinal lesions in rats by the new specific antagonist N-(2-dimethylaminoethyl)-N-(3-pyridinylmethyl)[4-(2,4,6-triisopropylphe nyl) thiazol-2yl]amine. Giudice, A., Herbert, J.M., Maffrand, J.P., Manara, L., Manzoni, L., Le Fur, G. Arzneimittel-Forschung. (1996)
- Platelet-leukocyte cross talk in whole blood. Li, N., Hu, H., Lindqvist, M., Wikström-Jonsson, E., Goodall, A.H., Hjemdahl, P. Arterioscler. Thromb. Vasc. Biol. (2000)
- Ex vivo effects of SR 27417, a novel PAF antagonist, on rabbit platelet aggregation and [3H]-PAF binding. Herbert, J.M., Laplace, M.C., Maffrand, J.P. Journal of lipid mediators. (1992)