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Gene Review

Ptafr  -  platelet-activating factor receptor

Rattus norvegicus

Synonyms: PAF-R, PAFr, Platelet-activating factor receptor
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Disease relevance of Ptafr

  • Furthermore, the hypotension and intestinal injury was prevented by PAF receptor blockade [1].
  • To determine whether PAF receptor (PAFR) expression is altered during excitotoxicity, changes in PAFR mRNA localization were compared with markers of neuronal apoptosis and reactive gliosis following systemic injection of kainic acid [2].
  • The production of platelet-activating factor (PAF) and PAF-like phospholipids that also bind the PAF receptor are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage [3].
  • Pulmonary responses detected (i.e., eicosanoid production, leukocytic infiltration, Evan's blue extravasation, beta-glucuronidase release) were attenuated to varying degrees by treatment of rats in which pancreatitis was initiated with the PAF receptor antagonists (WEB2170 and BN52021) [4].
  • With the use of this novel PAF receptor antagonist, the in vivo mediator role of PAF in the soluble immune complex-induced hypotension, extravasation, vascular lysosomal hydrolase secretion, and neutropenia in rats was determined [5].

Psychiatry related information on Ptafr


High impact information on Ptafr


Chemical compound and disease context of Ptafr


Biological context of Ptafr


Anatomical context of Ptafr


Associations of Ptafr with chemical compounds

  • Previous injection of the specific platelet-activating factor receptor antagonists, BN 52021 or BN 50730, was also unable to restore a normal marker excretion profile after administration of trinitrobenzene sulfonic acid [25].
  • Platelet activating factor (PAF) is a potent phospholipid mediator which elicits a diverse array of biological actions by interacting with G protein-coupled PAF receptors (PAFR) [26].
  • Therefore, using 16 rats, we studied the effects of the platelet activating factor receptor blockers BN 52021 (10 mg/kg, n = 4 or 30 mg/kg, n = 2) and WEB 2086 (5 mg/kg, n = 6) on global cerebral blood flow and the cerebral metabolic rate for oxygen and compared them with the effect of indomethacin (10 mg/kg, n = 4) [27].
  • This enhancement was blocked by three structurally unrelated specific PAF receptor antagonists BN 52021, WEB 2170, and CV 3988 [28].
  • Although PAF stimulated 10-fold increases in inositol phosphate accumulation in rPAFR transfectants, it had no effects on inositol phosphate accumulation in amphipathic helix mutant PAFR transfectants [29].

Regulatory relationships of Ptafr

  • 2. Pre-treatment with the PAF receptor antagonist WEB 2086 inhibited des-Arg(9)-BK-induced oedema in IL-1 beta-treated paws, while the LTB(4) receptor antagonist CP105696 had no effect [30].
  • The PAF receptor antagonist WEB 2170 almost completely blocked the ATS and RS induced MCP-1 mRNA levels [31].

Other interactions of Ptafr


Analytical, diagnostic and therapeutic context of Ptafr


  1. The role of endogenous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats. Caplan, M.S., Hedlund, E., Hill, N., MacKendrick, W. Gastroenterology (1994) [Pubmed]
  2. Platelet activating factor receptor expression is associated with neuronal apoptosis in an in vivo model of excitotoxicity. Bennett, S.A., Chen, J., Pappas, B.A., Roberts, D.C., Tenniswood, M. Cell Death Differ. (1998) [Pubmed]
  3. The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. Howard, K.M., Olson, M.S. J. Biol. Chem. (2000) [Pubmed]
  4. Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat. Zhou, W., McCollum, M.O., Levine, B.A., Olson, M.S. Am. J. Pathol. (1992) [Pubmed]
  5. Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. Doebber, T.W., Wu, M.S., Biftu, T. J. Immunol. (1986) [Pubmed]
  6. Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. Marcheselli, V.L., Bazan, N.G. J. Biol. Chem. (1996) [Pubmed]
  7. Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells. Heery, J.M., Kozak, M., Stafforini, D.M., Jones, D.A., Zimmerman, G.A., McIntyre, T.M., Prescott, S.M. J. Clin. Invest. (1995) [Pubmed]
  8. Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. Bito, H., Nakamura, M., Honda, Z., Izumi, T., Iwatsubo, T., Seyama, Y., Ogura, A., Kudo, Y., Shimizu, T. Neuron (1992) [Pubmed]
  9. Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. Clark, G.D., Happel, L.T., Zorumski, C.F., Bazan, N.G. Neuron (1992) [Pubmed]
  10. Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat. Warren, J.S., Mandel, D.M., Johnson, K.J., Ward, P.A. J. Clin. Invest. (1989) [Pubmed]
  11. Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. Chang, S.W., Feddersen, C.O., Henson, P.M., Voelkel, N.F. J. Clin. Invest. (1987) [Pubmed]
  12. Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. Perico, N., Delaini, F., Tagliaferri, M., Abbate, M., Cucchi, M., Bertani, T., Remuzzi, G. Lab. Invest. (1988) [Pubmed]
  13. Protective action of prostaglandin E1 (PGE1) against constrictor mediators in isolated rat heart and lung. Terashita, Z., Stahl, G.L., Lefer, A.M. Biochem. Pharmacol. (1988) [Pubmed]
  14. Dynamics of PAF-induced conjunctivitis reveals differential expression of PAF receptor by macrophages and eosinophils in the rat. Zinchuk, O., Fukushima, A., Hangstefer, E. Cell Tissue Res. (2004) [Pubmed]
  15. Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. Doebber, T.W., Wu, M.S., Robbins, J.C., Choy, B.M., Chang, M.N., Shen, T.Y. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  16. Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist. Handley, D.A., Van Valen, R.G., Melden, M.K., Flury, S., Lee, M.L., Saunders, R.N. Immunopharmacology (1986) [Pubmed]
  17. Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. Venkatesha, R.T., Ahamed, J., Nuesch, C., Zaidi, A.K., Ali, H. J. Biol. Chem. (2004) [Pubmed]
  18. Kinin B1 receptor up-regulation after lipopolysaccharide administration: role of proinflammatory cytokines and neutrophil influx. Passos, G.F., Fernandes, E.S., Campos, M.M., Araújo, J.G., Pesquero, J.L., Souza, G.E., Avellar, M.C., Teixeira, M.M., Calixto, J.B. J. Immunol. (2004) [Pubmed]
  19. Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death. Mukherjee, P.K., DeCoster, M.A., Campbell, F.Z., Davis, R.J., Bazan, N.G. J. Biol. Chem. (1999) [Pubmed]
  20. Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Arndt, H., Russell, J.B., Kurose, I., Kubes, P., Granger, D.N. Gastroenterology (1993) [Pubmed]
  21. Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. Kanwar, S., Johnston, B., Kubes, P. Circ. Res. (1995) [Pubmed]
  22. Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells. Mustafa, S.B., Flickinger, B.D., Olson, M.S. Hepatology (1999) [Pubmed]
  23. Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion. Zhou, W., McCollum, M.O., Levine, B.A., Olson, M.S. Hepatology (1992) [Pubmed]
  24. Predominant expression of platelet-activating factor receptor in the rat brain microglia. Mori, M., Aihara, M., Kume, K., Hamanoue, M., Kohsaka, S., Shimizu, T. J. Neurosci. (1996) [Pubmed]
  25. Leukotriene D4 participates in colonic transit disturbances induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. Pons, L., Droy-Lefaix, M.T., Bueno, L. Gastroenterology (1992) [Pubmed]
  26. The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C-activating G proteins. Studies using intracellular domain minigenes and receptor chimeras. Carlson, S.A., Chatterjee, T.K., Fisher, R.A. J. Biol. Chem. (1996) [Pubmed]
  27. Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain. Kochanek, P.M., Melick, J.A., Schoettle, R.J., Magargee, M.J., Evans, R.W., Nemoto, E.M. Stroke (1990) [Pubmed]
  28. Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. Thivierge, M., Rola-Pleszczynski, M. J. Allergy Clin. Immunol. (1992) [Pubmed]
  29. Mutation of a putative amphipathic alpha-helix in the third intracellular domain of the platelet-activating factor receptor disrupts receptor/G protein coupling and signaling. Carlson, S.A., Chatterjee, T.K., Murphy, K.P., Fisher, R.A. Mol. Pharmacol. (1998) [Pubmed]
  30. The role of migrating leukocytes in IL-1 beta-induced up-regulation of kinin B(1) receptors in rats. Campos, M.M., de Souza, G.E., Ricci, N.D., Pesquero, J.L., Teixeira, M.M., Calixto, J.B. Br. J. Pharmacol. (2002) [Pubmed]
  31. Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury. Jocks, T., Freudenberg, J., Zahner, G., Stahl, R.A. Nephrol. Dial. Transplant. (1998) [Pubmed]
  32. Endothelin-1-induced myocardial ischaemia and oedema in the rat: involvement of the ETA receptor, platelet-activating factor and thromboxane A2. Filep, J.G., Fournier, A., Földes-Filep, E. Br. J. Pharmacol. (1994) [Pubmed]
  33. Involvement of platelet-activating factor in cytokine production and neutrophil activation after hepatic ischemia-reperfusion. Serizawa, A., Nakamura, S., Suzuki, n.u.l.l., Baba, S., Nakano, M. Hepatology (1996) [Pubmed]
  34. The expression of cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-2) in rat peritoneal macrophages is triggered by Fc gamma receptor activation: study of the signaling mechanism. Alonso, A., Bayón, Y., Crespo, M.S. Eur. J. Immunol. (1996) [Pubmed]
  35. Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. Junier, M.P., Tiberghien, C., Rougeot, C., Fafeur, V., Dray, F. Endocrinology (1988) [Pubmed]
  36. Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis. Wang, X., Sun, Z., Börjesson, A., Haraldsen, P., Aldman, M., Deng, X., Leveau, P., Andersson, R. Int. J. Pancreatol. (1999) [Pubmed]
  37. Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. Flickinger, B.D., Olson, M.S. Am. J. Pathol. (1999) [Pubmed]
  38. The platelet activating factor receptor antagonist WEB 2170 improves glomerular hemodynamics and morphology in a proliferative model of mesangial cell injury. Stahl, R.A., Thaiss, F., Oberle, G., Brecht, H.M., Schoeppe, W., Wenzel, U., Helmchen, U.M. J. Am. Soc. Nephrol. (1991) [Pubmed]
  39. Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. Wang, H., Tan, X., Chang, H., Gonzalez-Crussi, F., Remick, D.G., Hsueh, W. Biochem. J. (1997) [Pubmed]
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