Gene Review:
Ptafr - platelet-activating factor receptor
Rattus norvegicus
Synonyms:
PAF-R, PAFr, Platelet-activating factor receptor
- The role of endogenous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats. Caplan, M.S., Hedlund, E., Hill, N., MacKendrick, W. Gastroenterology (1994)
- Platelet activating factor receptor expression is associated with neuronal apoptosis in an in vivo model of excitotoxicity. Bennett, S.A., Chen, J., Pappas, B.A., Roberts, D.C., Tenniswood, M. Cell Death Differ. (1998)
- The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. Howard, K.M., Olson, M.S. J. Biol. Chem. (2000)
- Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat. Zhou, W., McCollum, M.O., Levine, B.A., Olson, M.S. Am. J. Pathol. (1992)
- Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. Doebber, T.W., Wu, M.S., Biftu, T. J. Immunol. (1986)
- Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. Marcheselli, V.L., Bazan, N.G. J. Biol. Chem. (1996)
- Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells. Heery, J.M., Kozak, M., Stafforini, D.M., Jones, D.A., Zimmerman, G.A., McIntyre, T.M., Prescott, S.M. J. Clin. Invest. (1995)
- Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. Bito, H., Nakamura, M., Honda, Z., Izumi, T., Iwatsubo, T., Seyama, Y., Ogura, A., Kudo, Y., Shimizu, T. Neuron (1992)
- Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. Clark, G.D., Happel, L.T., Zorumski, C.F., Bazan, N.G. Neuron (1992)
- Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat. Warren, J.S., Mandel, D.M., Johnson, K.J., Ward, P.A. J. Clin. Invest. (1989)
- Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. Chang, S.W., Feddersen, C.O., Henson, P.M., Voelkel, N.F. J. Clin. Invest. (1987)
- Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. Perico, N., Delaini, F., Tagliaferri, M., Abbate, M., Cucchi, M., Bertani, T., Remuzzi, G. Lab. Invest. (1988)
- Protective action of prostaglandin E1 (PGE1) against constrictor mediators in isolated rat heart and lung. Terashita, Z., Stahl, G.L., Lefer, A.M. Biochem. Pharmacol. (1988)
- Dynamics of PAF-induced conjunctivitis reveals differential expression of PAF receptor by macrophages and eosinophils in the rat. Zinchuk, O., Fukushima, A., Hangstefer, E. Cell Tissue Res. (2004)
- Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. Doebber, T.W., Wu, M.S., Robbins, J.C., Choy, B.M., Chang, M.N., Shen, T.Y. Biochem. Biophys. Res. Commun. (1985)
- Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist. Handley, D.A., Van Valen, R.G., Melden, M.K., Flury, S., Lee, M.L., Saunders, R.N. Immunopharmacology (1986)
- Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. Venkatesha, R.T., Ahamed, J., Nuesch, C., Zaidi, A.K., Ali, H. J. Biol. Chem. (2004)
- Kinin B1 receptor up-regulation after lipopolysaccharide administration: role of proinflammatory cytokines and neutrophil influx. Passos, G.F., Fernandes, E.S., Campos, M.M., Araújo, J.G., Pesquero, J.L., Souza, G.E., Avellar, M.C., Teixeira, M.M., Calixto, J.B. J. Immunol. (2004)
- Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death. Mukherjee, P.K., DeCoster, M.A., Campbell, F.Z., Davis, R.J., Bazan, N.G. J. Biol. Chem. (1999)
- Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Arndt, H., Russell, J.B., Kurose, I., Kubes, P., Granger, D.N. Gastroenterology (1993)
- Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. Kanwar, S., Johnston, B., Kubes, P. Circ. Res. (1995)
- Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells. Mustafa, S.B., Flickinger, B.D., Olson, M.S. Hepatology (1999)
- Inflammation and platelet-activating factor production during hepatic ischemia/reperfusion. Zhou, W., McCollum, M.O., Levine, B.A., Olson, M.S. Hepatology (1992)
- Predominant expression of platelet-activating factor receptor in the rat brain microglia. Mori, M., Aihara, M., Kume, K., Hamanoue, M., Kohsaka, S., Shimizu, T. J. Neurosci. (1996)
- Leukotriene D4 participates in colonic transit disturbances induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. Pons, L., Droy-Lefaix, M.T., Bueno, L. Gastroenterology (1992)
- The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C-activating G proteins. Studies using intracellular domain minigenes and receptor chimeras. Carlson, S.A., Chatterjee, T.K., Fisher, R.A. J. Biol. Chem. (1996)
- Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain. Kochanek, P.M., Melick, J.A., Schoettle, R.J., Magargee, M.J., Evans, R.W., Nemoto, E.M. Stroke (1990)
- Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. Thivierge, M., Rola-Pleszczynski, M. J. Allergy Clin. Immunol. (1992)
- Mutation of a putative amphipathic alpha-helix in the third intracellular domain of the platelet-activating factor receptor disrupts receptor/G protein coupling and signaling. Carlson, S.A., Chatterjee, T.K., Murphy, K.P., Fisher, R.A. Mol. Pharmacol. (1998)
- The role of migrating leukocytes in IL-1 beta-induced up-regulation of kinin B(1) receptors in rats. Campos, M.M., de Souza, G.E., Ricci, N.D., Pesquero, J.L., Teixeira, M.M., Calixto, J.B. Br. J. Pharmacol. (2002)
- Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury. Jocks, T., Freudenberg, J., Zahner, G., Stahl, R.A. Nephrol. Dial. Transplant. (1998)
- Endothelin-1-induced myocardial ischaemia and oedema in the rat: involvement of the ETA receptor, platelet-activating factor and thromboxane A2. Filep, J.G., Fournier, A., Földes-Filep, E. Br. J. Pharmacol. (1994)
- Involvement of platelet-activating factor in cytokine production and neutrophil activation after hepatic ischemia-reperfusion. Serizawa, A., Nakamura, S., Suzuki, n.u.l.l., Baba, S., Nakano, M. Hepatology (1996)
- The expression of cytokine-induced neutrophil chemoattractants (CINC-1 and CINC-2) in rat peritoneal macrophages is triggered by Fc gamma receptor activation: study of the signaling mechanism. Alonso, A., Bayón, Y., Crespo, M.S. Eur. J. Immunol. (1996)
- Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. Junier, M.P., Tiberghien, C., Rougeot, C., Fafeur, V., Dray, F. Endocrinology (1988)
- Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis. Wang, X., Sun, Z., Börjesson, A., Haraldsen, P., Aldman, M., Deng, X., Leveau, P., Andersson, R. Int. J. Pancreatol. (1999)
- Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. Flickinger, B.D., Olson, M.S. Am. J. Pathol. (1999)
- The platelet activating factor receptor antagonist WEB 2170 improves glomerular hemodynamics and morphology in a proliferative model of mesangial cell injury. Stahl, R.A., Thaiss, F., Oberle, G., Brecht, H.M., Schoeppe, W., Wenzel, U., Helmchen, U.M. J. Am. Soc. Nephrol. (1991)
- Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. Wang, H., Tan, X., Chang, H., Gonzalez-Crussi, F., Remick, D.G., Hsueh, W. Biochem. J. (1997)