Chemical Compound Review:
trapoxin A (3S,6S,9S,12R)-3,6-dibenzyl- 9-[6-[(2S)...
Synonyms:
LS-172860, AC1L3TK4, C34H42N4O6, 133155-89-2
- Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. Van Lint, C., Emiliani, S., Ott, M., Verdin, E. EMBO J. (1996)
- Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1. Zhou, Q., Melkoumian, Z.K., Lucktong, A., Moniwa, M., Davie, J.R., Strobl, J.S. J. Biol. Chem. (2000)
- Inhibition of histone deacetylases induces bovine leukemia virus expression in vitro and in vivo. Merezak, C., Reichert, M., Van Lint, C., Kerkhofs, P., Portetelle, D., Willems, L., Kettmann, R. J. Virol. (2002)
- Activation of the MAP kinase cascade by histone deacetylase inhibitors is required for the stimulation of choline acetyltransferase gene promoter. Espinos, E., Weber, M.J. Brain Res. Mol. Brain Res. (1998)
- Histone deacetylase activity is required for full transcriptional repression by mSin3A. Hassig, C.A., Fleischer, T.C., Billin, A.N., Schreiber, S.L., Ayer, D.E. Cell (1997)
- A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Taunton, J., Hassig, C.A., Schreiber, S.L. Science (1996)
- Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Furumai, R., Komatsu, Y., Nishino, N., Khochbin, S., Yoshida, M., Horinouchi, S. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase. Kwon, H.J., Owa, T., Hassig, C.A., Shimada, J., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1998)
- A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Hassig, C.A., Tong, J.K., Fleischer, T.C., Owa, T., Grable, P.G., Ayer, D.E., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Induction of gamma-globin by histone deacetylase inhibitors. McCaffrey, P.G., Newsome, D.A., Fibach, E., Yoshida, M., Su, M.S. Blood (1997)
- Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Yoshida, M., Horinouchi, S., Beppu, T. Bioessays (1995)
- Temporally restricted spatial localization of acetylated isoforms of histone H4 and RNA polymerase II in the 2-cell mouse embryo. Worrad, D.M., Turner, B.M., Schultz, R.M. Development (1995)
- Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. Kijima, M., Yoshida, M., Sugita, K., Horinouchi, S., Beppu, T. J. Biol. Chem. (1993)
- A novel tetracyclic peptide, trapoxin, induces phenotypic change from transformed to normal in sis-oncogene-transformed NIH3T3 cells. Yoshida, H., Sugita, K. Jpn. J. Cancer Res. (1992)
- Characterization of a human RPD3 ortholog, HDAC3. Emiliani, S., Fischle, W., Van Lint, C., Al-Abed, Y., Verdin, E. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. Wang, S., Yan-Neale, Y., Fischer, D., Zeremski, M., Cai, R., Zhu, J., Asselbergs, F., Hampton, G., Cohen, D. Oncogene (2003)
- Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects. Sambucetti, L.C., Fischer, D.D., Zabludoff, S., Kwon, P.O., Chamberlin, H., Trogani, N., Xu, H., Cohen, D. J. Biol. Chem. (1999)