Disease relevance of N-Propylnitrosourea

• Morphologic characteristics of thymic lymphomas induced by N-nitroso-N-propylurea in F344 rats [1].
• Eighty-two thymic tumors induced by N-nitroso-N-propylurea in inbred F344/DuCrj rats were examined by light and electron microscopy [1].
• Induction of Leukemias and digestive tract tumors in Donryu rats by 1-propyl-1-nitrosourea [2].
• Influence of DNA repair by (A)BC excinuclease and Ogt alkyltransferase on the distribution of mutations induced by n-propyl-N-nitrosourea in Escherichia coli [3].
• Induction of lung tumors and peritoneal mesotheliomas in F344 rats given intragastric N-propyl-N-nitrosourea and histochemical, immunohistochemical, and ultrastructural characteristics of induced mesotheliomas [4].

High impact information on N-Propylnitrosourea

• Existence of N-nitroso-N-propylurea target cells in the thymus of F344 rats in thymic lymphomagenesis [5].
• N-Nitroso-N-propylurea [(NPU) CAS: 816-57-9] induces high incidence of thymic lymphoma in F344 rats [5].
• The carcinogenic effectiveness of a number of nitrosoalkylamides related to nitrosoethylurea and nitroso-n-propylurea has been compared by topical application to Swiss mice and by intragastric administration to F344 rats [6].
• Of the compounds assayed, all noncarcinogens failed to induce DNA repair; of 38 compounds of demonstrated carcinogenicity, 34 were active; safrole, N-propyl-N-nitrosourea, aflatoxin B2 and N-butyl-N-nitrosourea were, however, inactive [7].
• The results are also discussed in terms of understanding the solvolysis products and DNA adducts previously observed from the metabolism of dipropylnitrosamine and the hydrolysis of N-propyl-N-nitrosourea [8].

Biological context of N-Propylnitrosourea

• As a part of the 2nd Collaborative Study for the Transgenic Mouse Mutation Assay, we studied the organ specificity and the temporal changes in mutant frequency (MF) of the lacZ gene following intraperitoneal injection of 250 mg/kg N-propyl-N-nitrosourea into male MutaMouse [9].
• Chromosome and cell surface marker studies in 1-propyl-1-nitrosourea-induced thymic lymphomas of the rat [10].
• Cytogenetic studies on rat thymic lymphomas induced by N-propyl-N-nitrosourea [11].

Anatomical context of N-Propylnitrosourea

• The induction of specific-locus mutations with N-propyl-N-nitrosourea in stem-cell spermatogonia of mice [12].
• A specific-locus test to determine the effect of N-propyl-N-nitrosourea (PNU) on the stem-cell spermatogonia of mice has been performed [12].
• N-Propyl-N-nitrosourea (PNU) is shown to be active in male mouse bone marrow micronucleus assays when dosed at either 100 or 200 mg/kg in saline [13].
• Mutagenicity to the mouse bone marrow by the mouse germ cell mutagen N-propyl-N-nitrosourea [13].
• Immunological cell surface markers were studied in seven transplantable 1-propyl-1-nitrosourea-induced thymic lymphoma lines in F344 rats by reactivity to anti-Thy-1.1, anti-rat Ig (anti-Ig), and anti-rat T-cell (anti-T) sera, and by the capacity to form rosettes with guinea pig red blood cells [10].

Gene context of N-Propylnitrosourea

• To clarify whether the determining effect of the thymic lymphoma susceptible-1 (Tls-1) gene is on putative N-propyl-N-nitrosourea (PNU) target cells among T-lineage cells or on other host factors, we investigated the PNU-induced lymphomagenesis in transplantation chimeras between susceptible F344 and resistant LES strain rats [14].
• In the absence of nucleotide excision repair, the additional deficiency of the DNA alkyltransferase (ATase) encoded by the constitutive ogt gene of Escherichia coli caused a marked increment in mutation induction by N-propyl-N-nitrosourea (PNU) [3].

Analytical, diagnostic and therapeutic context of N-Propylnitrosourea

• Development of thymic lymphomas by oral administration of N-nitroso-N-propylurea and establishment of transplantable lines of thymic lymphoma in F344 rats [15].
• Mammary and subcutaneous tumors were found in some rats given a subcutaneous injection of 1-propyl-1-nitrosourea [16].

References